Lichenoid reaction induced by adalimumab

Simone, Clara De; Caldarola, Giacomo; D’agostino, M. A.; Rotoli, M; Capizzi, Rodolfo; Amerio, Pierluigi

doi:10.1111/j.1468-3083.2007.02413.x

Cited by 30 publications

(18 citation statements)

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“…Eleven similar cases have been previously reported in 10 patients, [10][11][12][13][14][15][16][17] including one patient who developed lichenoid reactions to both adalimumab and lenercept. Key features of these 13 eruptions in 12 patients are summarized in Table I.…”

Section: Discussionmentioning

confidence: 62%

“…In some cases, mucocutaneous lesions were described as having features similar to idiopathic LP, such as violaceous flat-topped polygonal papules, 16 violaceous papular lesions with mild scale, 15 purple-colored erythematosquamous plaques, 12 erythematous polygonal papules, 11 or reticulate white mucosal plaques. 13,14 Other skin lesions were less specific, being described only as an ''erythematous papular rash,'' 10 a ''maculopapular exanthema,'' 17 or white oral plaques. 15 Some features typical of LP were also seen in our two patients.…”

Section: Discussionmentioning

confidence: 99%

“…Six occurred after treatment with infliximab, 3 with etanercept, 3 with adalimumab, and one with lenercept. The time from initiation of TNF-a blockade to the appearance of a lichenoid eruption varied from 3 weeks to 16 months,[10][11][12][13][14][15][16][17] although onset within the first 2 months of therapy was most common.…”

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confidence: 99%

“…3,10 A number of so-called lichenoid eruptions have also been reported, falling at different points on the spectrum of lichenoid inflammation. These cases are unified by a common lichenoid histology, but can be divided into 3 groups based on their clinical appearance: those with clinical features similar to lichen planus (LP), [11][12][13][14][15][16] those with a nonspecific macular or papular morphology, 10,17 and those that are clinically typical of psoriasis but show lichenoid histologic features. 18,19 We present two cases of LP-like eruptions in patients taking TNF-a inhibitors.…”

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confidence: 99%

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Lichen planus–like eruptions: An emerging side effect of tumor necrosis factor-α antagonists

Asarch

Gottlieb

Liu

et al. 2009

Journal of the American Academy of Dermatology

172

105

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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Lichen planus–like eruptions: An emerging side effect of tumor necrosis factor-α antagonists

Asarch

Gottlieb

Liu

et al. 2009

Journal of the American Academy of Dermatology

172

105

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“…Targeted therapy with biological agents has also provided new therapeutic options for patients with moderate to severe psoriasis, but paradoxically, there have been reported of new‐onset psoriasis in patients treated with TNF‐α inhibitors, although the exact mechanism remains unclear 2 . Other dermatological side effects have been reported with adalimumab including skin rash, urticaria, eczema, lymphomatoid papulosis, erythema multiforme, lichenoid reactions, vasculitis, rosacea, pityriasis rosea, folliculitis, lupus, herpes zoster, fungal and bacterial infections, actinic keratosis, squamous and basal cell carcinoma 3–7 …”

mentioning

confidence: 99%

Palmoplantar psoriasis: a paradoxical adverse reaction induced by adalimumab

Bordel-Gómez¹,

Sánchez-Estella²,

Martínez‐González

et al. 2009

Acad Dermatol Venereol

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in all cases, indicating the difficulty in identifying these lesions clinically. In fact, there was a report of a 12-year-old with ectopic sebaceous glands on the penis, which were clinically similar to ours, but histologically, the lesions demonstrated epidermal hyperplasia rather than sebaceous gland hyperplasia. 6 Clinically, SH of the penile shaft should be differentiated from pearly penile papules, molluscum contagiosum, Bowenoid papulosis, genital warts and lichen nitidus. Pearly penile papules are arranged in rows and are usually localized at the coronal edge. In our case, the papules were irregularly distributed and not confined to the coronal edge. Bowenoid papulosis and genital warts are multiform in size and shape and grow substantially with time, whereas in our case, the papules were uniform and showed minimal change over time. The individual lesions in lichen nitidus are white, glistening and flat, which is distinct from the yellowish, dome-shaped papules of SH.Histologically, the differential diagnoses include ectopic sebaceous glands, naevus sebaceous, sebaceous adenoma and sebaceous epithelioma. Although there is no universally accepted definition of SH, Wick et al . 1 defined SH by the presence of ≥ 4 sebaceous lobules attached to an infundibulum of a pilosebaceous unit. The cells comprising the lobules are fully mature with a thin rim of basaloid cells present at the periphery. It must be distinguished from ectopic sebaceous glands, where a group of small, mature sebaceous lobules are situated around a small sebaceous duct without an attached follicle. Naevus sebaceous differs from SH by the presence of hamartomatous pilosebaceous units, papillomatous epidermal hyperplasia and frequent apocrine elements. Sebaceous adenoma and sebaceous epithelioma commonly show multilayers of undifferentiated basaloid cells in the periphery. 1 In conclusion, our case suggests that SH should be considered in the differential diagnosis of a patient with tiny papular lesions on the penis. It is important to reassure the patient that this condition is not infectious. There is no need to pursue treatment other than for cosmetic reasons. References1 Wick MR, Swanson PE, Barnhill RL. Sebaceous and pilar tumors. In: Crowson AN, Barnhill RL, eds. Textbook of Dermatopathology , 2nd edn. The McGraw-Hill, New York, 2004: 709-715. 2 Hyman AB, Brownstein MH. Tyson's 'glands'. Ectopic sebaceous glands and papillomatosis penis. Arch Dermatol 1969; 99 : 31-36. 3 Vergara G, Belinchón I, Sivestre JF, Albares MP, Pascual JC. Linear sebaceous gland hyperplasia of the penis: a case report. J Am Acad Dermatol 2003; 48 : 149-150. 4 Kumar A, Kossard S. Band-like sebaceous hyperplasia over the penis. Australas J Dermatol 1999; 40 : 47-48. 5 Carson HJ, Massa M, Reddy V. Sebaceous gland hyperplasia of the penis.

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Lichen Planus and Lichenoid Disorders

Breathnach

2010

Rook's Textbook of Dermatology

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Lichenoid reaction induced by adalimumab

Cited by 30 publications

References 3 publications

Lichen planus–like eruptions: An emerging side effect of tumor necrosis factor-α antagonists

Lichen planus–like eruptions: An emerging side effect of tumor necrosis factor-α antagonists

Palmoplantar psoriasis: a paradoxical adverse reaction induced by adalimumab

Lichen Planus and Lichenoid Disorders

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