Lichtbiologie der Haut

Jung, Ernst G.; Bohnert, E.

doi:10.1007/978-3-642-46393-8_6

Cited by 8 publications

(3 citation statements)

References 354 publications

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“…These different results may be the consequence of using different light sources and measuring in different phases of UV erythema. For the same reason, predictions cannot be made from these results relative to the erythemogenic action of narrow band UVB (311 nm) in old age, especially since the erythemogenic potency of this wavelength is substantially lower than that of shorter wavelengths (8). The primary objective of the present study was to determine whether the greater intensity of UVB erythema in the late phase of UVB erythema observed by Guerrera (3) in elderly people receiving narrow‐band UVB therapy can be confirmed and, if so, whether this may translate into specific considerations for narrow‐band UVB therapy in the elderly.…”

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confidence: 99%

Age dependence of ultraviolet light‐induced erythema following narrow‐band UVB exposure

Gloor

Scherotzke

2002

Photoderm Photoimm Photomed

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confidence: 99%

Age dependence of ultraviolet light‐induced erythema following narrow‐band UVB exposure

Gloor

Scherotzke

2002

Photoderm Photoimm Photomed

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“…Anthralin dermatitis was evaluated by grading erythema (comparing with Ko dak color filters CC05R, CC10R. CC20R, CC30R, CC40R and CC50R) [15]. The minimal erythema response corresponded to CC10R, which was used as reference point 1.…”

Section: Evaluation O F the Inflammatory Reactionmentioning

confidence: 99%

Antioxidant Inhibition of Skin Inflammation Induced by Reactive Oxidants: Evaluation of the Redox Couple Dihydrolipoate/Lipoate

Fuchs

Milbradt

1994

Skin Pharmacol Physiol

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Reactive oxygen species play an important role in mediating skin inflammation, and antioxidants may provide protection. We investigated the anti-inflammatory activity of natural antioxidants, such as superoxide dismutase, catalase, trolox (a water-soluble tocopherol analog) and the redox couple dihy-drolipoate/lipoate in skin. Furthermore we compared the anti-inflammatory potency of natural R and racemic dihydroli-poate, as well as R and S lipoate. Skin inflammation in hairless mice was induced by intradermal injection of the hydrogen peroxide producing enzyme glucose oxidase (GOD) or by topical application of the prooxidant drug anthralin. Intradermal injection of the antioxidants inhibited skin inflammation caused by GOD (catalase, dihydrolipoate) and anthralin (trolox, superoxide dismutase, dihydrolipoate). There was no statistically significant difference between the anti-inflammatory activity of the natural R and racemic dihydrolipoate. R or S lipoate did not inhibit skin inflammation when injected intradermally. In feeding experiments, however, R lipoate significantly inhibited GOD-mediated skin inflammation, while S lipoate was only marginally protective. We conclude that (1) several natural antioxidants such as catalase, superoxide dismutase and dihydrolipoate have anti-inflammatory properties in dermatitis induced by reactive oxidants, (2) lipoate (oxidized dihydrolipoate) has skin anti-inflammatory activity when administered orally and (3) naturally occurring R lipoate is a more potent anti-inflammatory agent than the non-physiological S lipoate.

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“…However, other insults that occur during UV irradiation do not happen during intrinsic aging. Six to 24 hours after UVB irradiation there is a dose‐dependent reduction in the mitotic activity in the basal layer of the epidermis, 12 followed by an increase of unscheduled DNA synthesis in keratinocytes, melanocytes, and fibroblasts 12–14 . This unscheduled synthesis is the result of an excision repair process removing UV‐induced pyrimidine dimers in DNA (Fig.…”

Section: Molecular Mechanisms Of Photo Agingmentioning

confidence: 99%

Cellular and Molecular Mechanisms of Cutaneous Aging

Yaar

Gilchrest

1990

The Journal of Dermatologic Surgery and Oncology

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There are two major theories of aging: the programmatic theory states that aging is an inherent genetic process, and the stochastic theory states that aging represents random environmental damage. Processes that are associated with cellular damage and aging are the production of free radicals (a process much enhanced after ultraviolet irradiation) and an increasing number of errors during DNA replication. Cellular manifestations of intrinsic aging include decreased life span of cells, decreased responsiveness of cells to growth signals, which may reflect loss of cellular receptors to growth factors, and increased responsiveness to growth inhibitors. All these findings are more pronounced in cells derived from photodamaged skin. Molecular manifestations of intrinsic aging, studied mainly in fibroblasts, are altered membrane composition, adhesion properties, production of extracellular matrix, and activity of the enzyme catalase. Molecular changes as a result of photoaging are less well characterized; published studies mainly target differences in composition of the extracellular dermal matrix.

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Lichtbiologie der Haut

Cited by 8 publications

References 354 publications

Age dependence of ultraviolet light‐induced erythema following narrow‐band UVB exposure

Age dependence of ultraviolet light‐induced erythema following narrow‐band UVB exposure

Antioxidant Inhibition of Skin Inflammation Induced by Reactive Oxidants: Evaluation of the Redox Couple Dihydrolipoate/Lipoate

Cellular and Molecular Mechanisms of Cutaneous Aging

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