Lichtheimia hongkongensis sp. nov., a novel Lichtheimia spp. associated with rhinocerebral, gastrointestinal, and cutaneous mucormycosis

Woo, Patrick C. Y.; Lau, Susanna K. P.; Ngan, Antonio H. Y.; Tung, Edward T. K.; Leung, Suet Yi; To, Kelvin Kai‐Wang; Cheng, Vincent Chi-Chung; Yuen, Kwok‐Yung

doi:10.1016/j.diagmicrobio.2009.10.009

Cited by 25 publications

(31 citation statements)

References 16 publications

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“…The more widespread use of ITS and other gene sequencing has enabled clinical microbiology laboratories to con- fidently identify molds that are rarely found in patients after preliminary morphological examination (13)(14)(15)(16)(17)(18)29). In addition, novel fungal species associated with clinical infections have been discovered (9)(10)(11). These have greatly improved our understanding in the epidemiology, laboratory diagnosis, and treatment of fungal infections.…”

Section: Discussionmentioning

confidence: 99%

“…In the last decade, more widespread use of internal transcribed spacer 1 (ITS1)-5.8S-ITS2 rRNA gene cluster sequencing and sequencing of other conserved DNA regions has proved to be useful for identifying molds (8)(9)(10). In addition, it has led to the discovery of novel pathogenic fungal species (11,12). In the last decade, a number of case reports, with the help of ITS, ␤-tubulin, and calmodulin gene sequencing, have identified Aspergillus nomius and Aspergillus tamarii as causes of human infections (13)(14)(15)(16)(17)(18).…”

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confidence: 99%

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Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: Characterization by Internal Transcribed Spacer, β-Tubulin, and Calmodulin Gene Sequencing, Metabolic Fingerprinting, and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry

et al. 2014

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: Characterization by Internal Transcribed Spacer, β-Tubulin, and Calmodulin Gene Sequencing, Metabolic Fingerprinting, and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry

et al. 2014

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“…In fact, one of the three reported cases of severe P. malariae infections was confirmed by SSU rRNA sequencing (5). Similar to what was found for bacterial and fungal infections (20)(21)(22), a polyphasic approach using a combination of phenotypic identification and rRNA sequencing is required for identification and novel species discovery in parasitic infections in the long run.…”

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confidence: 71%

Complication of Corticosteroid Treatment by Acute Plasmodium malariae Infection Confirmed by Small-Subunit rRNA Sequencing

Teng

Wong

et al. 2010

J Clin Microbiol

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We report a case of acute Plasmodium malariae infection complicating corticosteroid treatment for membranoproliferative glomerulonephritis in a patient from an area where P. malariae infection is not endemic. A peripheral blood smear showed typical band-form trophozoites compatible with P. malariae or Plasmodium knowlesi. SSU rRNA sequencing confirmed the identity to be P. malariae. CASE REPORTA 72-year-old man with membranoproliferative glomerulonephritis, hypertension, and ␣-thalassemia trait was admitted to our hospital because of chills and rigor for 2 days and a fever on the day of admission. He had been diagnosed with membranoproliferative glomerulonephritis 3 years prior to admission, when he presented with nephrotic syndrome. Autoimmune marker testing showed a raised level of antinuclear antibody (Ͼ1/720), with a normal level of anti-double-stranded-DNA antibody (Ͻ5 IU/ml) and a negative result for antineutrophil cytoplasmic antibody (ANCA). Testing for hepatitis B virus surface antigen showed a negative result. His initial renal biopsy specimen at diagnosis showed immune deposits of IgA, IgG, IgM, C3, and C1q. He was treated with high-dose corticosteroid with partial response. Two months prior to admission, he had recurrent lower limb edema and was confirmed to have a relapse of the nephrotic syndrome, with urine protein excretion of 2.78 g/day. Prednisolone at 50 mg once daily was started 50 days before admission, with a gradual tailing dose. On the day of admission, his prednisolone dosage was 35 mg once daily. The patient was a resident of Hong Kong. He occasionally traveled to southern China, but he has never traveled outside this area in his lifetime. He has never received a blood transfusion.On admission, he had a temperature of 39.3°C and a heart rate of 138 beats per minute. His blood pressure was 144/68 mm Hg. Physical examination revealed bilateral lower limb edema. The spleen was not palpable. A blood test showed thrombocytopenia with a platelet count of 69 ϫ 10 9 /liter. The platelet count 6 weeks before admission was within the normal range (253 ϫ 10 9 /liter). The total white cell count was 4.4 ϫ 10 9 /liter, with a neutrophil count of 4.09 ϫ 10 9 /liter and a lymphocyte count of 0.26 ϫ 10 9 /liter. The hemoglobin level was 7.4 g/dl. Biochemical tests revealed a creatinine level of 2.68 mg/dl and an albumin level of 31 g/liter. The levels for bilirubin and liver parenchymal enzymes were within the normal range. A peripheral blood smear showed normalsized erythrocytes, thick rings (Fig. 1a), band-form trophozoites (Fig. 1b), and schizonts containing dark brown pigments (Fig. 1c), compatible with Plasmodium malariae or P. knowlesi.

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“…Recently, we and others described a novel Lichtheimia species, Lichtheimia ramosa (syn. Lichtheimia hongkongensis ), from patients with mucormycosis (4, 5). We also found that a significant number of reported L. corymbifera infections were actually caused by L. ramosa (6).…”

Section: Genome Announcementmentioning

confidence: 99%

Complete Mitochondrial Genome Sequence of Lichtheimia ramosa (syn. Lichtheimia hongkongensis )

et al. 2014

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We report the complete mitochondrial genome sequence of Lichtheimia ramosa (syn. Lichtheimia hongkongensis), the first complete mitochondrial DNA sequence of the genus Lichtheimia. This 31.8-kb mitochondrial genome encodes 11 subunits of respiratory chain complexes, 3 ATP synthase subunits, 25 tRNAs, and small and large rRNAs, with the gene order atp9-cox2-atp6-cox3-cox1-nad2-nad3-cob-nad1-nad6-nad5-nad4l-nad4-atp8.

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Lichtheimia hongkongensis sp. nov., a novel Lichtheimia spp. associated with rhinocerebral, gastrointestinal, and cutaneous mucormycosis

Cited by 25 publications

References 16 publications

Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: Characterization by Internal Transcribed Spacer, β-Tubulin, and Calmodulin Gene Sequencing, Metabolic Fingerprinting, and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry

Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: Characterization by Internal Transcribed Spacer, β-Tubulin, and Calmodulin Gene Sequencing, Metabolic Fingerprinting, and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry

Complication of Corticosteroid Treatment by Acute Plasmodium malariae Infection Confirmed by Small-Subunit rRNA Sequencing

Complete Mitochondrial Genome Sequence of Lichtheimia ramosa (syn. Lichtheimia hongkongensis )

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