Licorice Extract Does Not Impair the Male Reproductive Function of Rats

Shin, Sunhee; Jang, Ja Young; Choi, Byong-il; Baek, In-Jeoung; Yon, Jung-Min; Hwang, Bang Yeon; Park, Dongsun; Jeon, Jeong Hee; Nam, Sang-Yoon; Yun, Young Won; Kim, Yun-Bae

doi:10.1538/expanim.57.11

Cited by 17 publications

(14 citation statements)

References 39 publications

(65 reference statements)

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“…Table (6) revels that the effect of the oral administration of licorice root extract at 15 mg/kg/day does not result statistically a significant differences in serum hormone levels of progesterone and testosterone and estradiol levels, (P>5.50) in the treated group as compared with the control group. The present results of effect of licorice root extract on testosterone hormone was in agreement with that illustrated in ref [86], as it has been reported that serum testosterone level tended to decrease without statistically significant difference between the control (mean 5.81 ng/ml) and treated (mean 5.65-5.66 ng/ml) rats, following 0 weeks treatment with licorice at high dose (1555 mg/Kg) group leading to reduction value of testosterone and did not show any abnormal signs. It was suggested that no observed adverse effect level of licorice extract at 055,1555 and at higher than 1555 mg/kg, the upper limit dose in the repeated dose toxicity protocol recommended in toxicity and that long term exposure to licorice might not cause profound adverse effects [86].…”

Section: Resultssupporting

confidence: 93%

“…The present results of effect of licorice root extract on testosterone hormone was in agreement with that illustrated in ref [86], as it has been reported that serum testosterone level tended to decrease without statistically significant difference between the control (mean 5.81 ng/ml) and treated (mean 5.65-5.66 ng/ml) rats, following 0 weeks treatment with licorice at high dose (1555 mg/Kg) group leading to reduction value of testosterone and did not show any abnormal signs. It was suggested that no observed adverse effect level of licorice extract at 055,1555 and at higher than 1555 mg/kg, the upper limit dose in the repeated dose toxicity protocol recommended in toxicity and that long term exposure to licorice might not cause profound adverse effects [86]. It has been reported that licorice reduce the serum testosterone level and affected androgen metabolism by inhibiting the enzyme β-6 HSD, and 17βHSD hydroxysteroid dehydrogenase or by stimulating aromatase.…”

Section: Resultssupporting

confidence: 93%

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Biological Effects of Stick Cherry, Soybean Seed and Licorice Root Extracts on Concentration of Serum Hormone Levels in Male Mice

Saleem¹,

Sulaiman²,

Mohammad³

et al. 2014

JNUS

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Background: This study was carried out to elucidate the effects of the oral administration of three types of herbs extract, stick cherry, soybean seed, and licorice root on concentration of the serum hormone, progesterone, testosterone, and estradiol in albino male mice. Objective: we investigated the impact of biological activity of stick cherry, soybean seed, licorice root extracts on serum concentrations of reproductive hormone as compared with untreated group. Materials and Methods: A total of 84 male mice were used in the experiment. The first group (G1) was the control group which comprised 11 mice treated with 5.0 mL/day distilled water. The remaining 63 mice were divided into (G1), (G6), and (G8). Each group comprised 11 mice. The mice in these groups were orally treated for 11 days with 5.0 mL/day stick cherry ethanol extract, soybean powder hexane extract, or licorice root ethanol extract at concentrations of 15, 15, and 15 mg/kg/day, respectively. Results and Discussions: Results show the effect of stick cherry ethanol extract induced a significant increase in serum concentration of progesterone and testosterone, and a remarkable decrease in estradiol concentration. Soybean extract induced a significant increase in serum concentration of progesterone, testosterone, and estradiol in the treated group compared with the untreated group. No significant effect statistically was found in progesterone, estradiol, and testosterone levels occurred in the group treated with licorice root extract compared with the untreated group. Conclusion: The extracts of stick cherry, and soybean seed exerts a remarkable effect on serum hormone concentration of reproductive organs, progesterone, testosterone and estradiol. Licorice root extract did not show any significant difference for all hormone levels. These extracts might be used as drugs and improve the function of reproductive organ or used as antifertility agents. There is no pharmacological or medical studies have evaluated the effect of stick cherry extract on reproductive hormones in male mice. Meanwhile, limited data and few references are available on the effects of soybean extracts licorice root on the serum hormone levels of reproductive organs.

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Section: Resultssupporting

confidence: 93%

Section: Resultssupporting

confidence: 93%

Biological Effects of Stick Cherry, Soybean Seed and Licorice Root Extracts on Concentration of Serum Hormone Levels in Male Mice

Saleem¹,

Sulaiman²,

Mohammad³

et al. 2014

JNUS

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“…There are no reports of licorice increasing pregnancy rates [19]; however, licorice extract improved the fertilization capacity of BALB/cA mouse sperm in vitro and fertilized eggs developed normally. In rats, licorice extract increased cyclophosphamide teratogenicity and upregulated the mRNA expression of cytochrome P-450 2B [20], suggesting that licorice root contains multiple components with biological activity that may not necessarily affect gene expression, given that transcription rates are low in spermatozoa [21].…”

Section: Activity Of Crude Licorice Extractmentioning

confidence: 92%

In vitro Fertilization with Mouse Sperm Activated by Components of Licorice Root Extract

Tung¹,

Tanaka²,

Tsujimura³

et al. 2016

Nat Prod Chem Res

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Licorice (Glycyrrhiza species) is an important natural product that is frequently used in traditional Chinese medicine. In this review article, we discuss the quality control of licorice using monoclonal antibodies against the licorice components glyzyrrhizin (GC) and liquiritin (Liq); the monitoring of licorice extract activity using an assay system in mice; and the isolation of two active phenolic components, isolitiritigenin and formononetin, and their effectiveness for improving in vitro fertilization in mice. Finally, we present the outstanding questions and potential applications of licorice root extract.

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“…Long‐term exposure to water extract of licorice (500, 1000, and 2000 mg/kg, orally, for 9 weeks) showed that NOAEL is higher than 2000 mg/kg. Besides, it had no significant toxicity effects in reproductive organs (Shin et al ., ).…”

Section: Toxicological Findingsmentioning

confidence: 99%

Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review

Nazari

Rameshrad

Hosseinzadeh

2017

Phytotherapy Research

210

110

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Licorice (Glycyrrhiza glabra) has been considered as an herbal drug since ancient time. Nowadays, it is a well-known spice that possesses worth pharmacological effects. However, some relevant articles have revealed negative impacts of licorice in health. By considering the great wishes in using herbal medicine, it is important to show adverse effects of herbal medicine in health. At present, there are misunderstandings toward the safety of herbal medicines. Herein, we gathered scientific research projects on the toxicity effects of licorice and glycyrrhizin to highlight their safety. In this regards, we categorized our findings about the toxicity effects of licorice and glycyrrhizin in acute, sub-acute, sub-chronic, and chronic states. Besides, we discussed on the cytotoxicity, genotoxicity, mutagenicity, and carcinogenicity of licorice and glycyrrhizin as well as their developmental toxicity. This review disclosed that G. glabra and glycyrrhizin salts are moderately toxic. They need to be used with caution during pregnancy. G. glabra and glycyrrhizin possess selective cytotoxic effects on cancerous cells. The most important side effects of licorice and glycyrrhizin are hypertension and hypokalemic-induced secondary disorders. Licorice side effects are increased by hypokalemia, prolonged gastrointestinal transient time, decreased type 2 11-beta-hydroxysteroid dehydrogenase activities, hypertension, anorexia nervosa, old age, and female sex. Copyright © 2017 John Wiley & Sons, Ltd.

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Licorice Extract Does Not Impair the Male Reproductive Function of Rats

Abstract: Abstract:The effect of water extract of licorice (Glycyrrhiza uralensis)

Cited by 17 publications

References 39 publications

Biological Effects of Stick Cherry, Soybean Seed and Licorice Root Extracts on Concentration of Serum Hormone Levels in Male Mice

Biological Effects of Stick Cherry, Soybean Seed and Licorice Root Extracts on Concentration of Serum Hormone Levels in Male Mice

In vitro Fertilization with Mouse Sperm Activated by Components of Licorice Root Extract

Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review

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