Lidocaine inhibits secretion of IL-8 and IL-1<b>β</b>and stimulates secretion of IL-1 receptor antagonist by epithelial cells

Lahav, Maor; Levite, Mia; Bassani, Laura; Lang, Alon; Fidder, Herma H.; Tal, Ruth; Bar‐Meir, Simon; Mayer, Lloyd; Chowers, Yehuda

doi:10.1046/j.1365-2249.2002.01747.x

Cited by 73 publications

(69 citation statements)

References 40 publications

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“…This likely reflects an awareness of the increasing body of published evidence supporting a pivotal role for inflammation in equine POI pathogenesis 3,13,14,15,16 . Similarly, it is likely that the reported anti-inflammatory effects of lidocaine 17,18,19 , in addition to its perceived prokinetic effects 2 , also contributed to the high frequency with which this drug was used, both intra-and postoperatively. Furthermore, in addition to inflammation, pain is recognised as an important risk factor for POI in both humans and horses 1,2,6,9,12,19 .…”

Section: Discussionmentioning

confidence: 99%

Clinical features and management of equine post operative ileus (POI):Survey ofDiplomates of theAmericanColleges ofVeterinaryInternalMedicine (ACVIM),VeterinarySurgeons (ACVS) andVeterinaryEmergency andCriticalCare (ACVECC)

Lefebvre

Hudson

Elce

et al. 2015

Equine Veterinary Journal

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Summary Reasons for performing study A recent survey of European Colleges (European College of Equine Internal Medicine [ECEIM] and European College of Veterinary Surgeons [ECVS]) revealed the different strategies implemented by, and some of the challenges facing, European clinicians presented with cases of post operative ileus (POI). It was concluded that further comparative analysis of opinions, canvassed from additional colleges of equine veterinary specialism worldwide, would provide valuable additional insight into current POI knowledge on a more global scale. Objectives To report and compare the current strategies favoured by American veterinary specialists when managing POI in horses that underwent emergency colic surgery. Study design Cross‐sectional survey. Methods Electronic invitations were sent to 814 Large Animal specialists, including 3 colleges: the American College of Veterinary Internal Medicine (ACVIM), American College of Veterinary Surgeons (ACVS) and the American College of Veterinary Emergency and Critical Care (ACVECC). Results The response rate was 14% (115/814). The majority of respondents (68%) reported an estimated prevalence range of POI of 0–20%. The presence of reflux on nasogastric intubation was the main criterion used to define POI. A lesion involving the small intestine was considered the main risk factor for POI. Anti‐inflammatory drugs, intravenous (i.v.) fluids and antimicrobial drugs were the primary strategies used when managing POI. Flunixin meglumine and i.v. lidocaine were the drugs most commonly used in the treatment of horses with POI. Supplementary management strategies targeted mainly the prevention of post operative adhesions, infection and inflammation. Conclusions There is a lack of consensus on the clinical definition of POI. Prospective and objective clinical assessment of the effectiveness of the different strategies contained within this and the European survey is necessary in order to identify a standardised approach to the management of equine POI.

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Section: Discussionmentioning

confidence: 99%

Clinical features and management of equine post operative ileus (POI):Survey ofDiplomates of theAmericanColleges ofVeterinaryInternalMedicine (ACVIM),VeterinarySurgeons (ACVS) andVeterinaryEmergency andCriticalCare (ACVECC)

Lefebvre

Hudson

Elce

et al. 2015

Equine Veterinary Journal

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“…The anti-inflammatory effects of lidocaine are attributable to attenuation of neurogenic inflammation and subsequent blockade of neural transmission at the site of tissue injury [146,162,164,165,167].…”

Section: Resultsmentioning

confidence: 99%

“…Its analgesic properties reflect the variable dose, time dependent, multimodal aspect of its action on voltage-gated channels receptors and neurotransmitters that affect nociceptive transmission pathways [24,45,[146][147][148]. In vitro, low dose lidocaine inhibits voltage-gated sodium channels (VGSC), some potassium channels, the glycinergic system, and G-protein coupled receptors.…”

Section: The Rationale For Ivlt In the Management Of Painmentioning

confidence: 99%

“…Lidocaine inhibits the migration of granulocytes and release of lysosomal enzymes which leads to decreased release of pro-and anti-inflammatory cytokines [146,162,[164][165][166][167]. Animal studies demonstrate that these anti-inflammatory effects of lidocaine are mediated by inhibition of VGSC, G-proteincoupled receptors and ATP-sensitive potassium channels.…”

Section: The Rationale For Ivlt In the Management Of Painmentioning

confidence: 99%

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A Review of Intravenous Lidocaine Infusion Therapy for Paediatric Acute and Chronic Pain Management

Lauder¹

2017

Pain Relief - From Analgesics to Alternative Therapies

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Pediatric acute and chronic pain experiences involve the interaction of physiological, psychological, behavioural, developmental, pharmacological and situational factors. In the acute perioperative pain setting preventative multimodal analgesia is required to provide comfort and minimise the potential for "wind-up" and central sensitisation. When pain is recurrent, ongoing or chronic some children embark on a downward spiral of decreased physical, psychological and social functioning. The multidisciplinary team management approach is a well-established standard of care for children with complex chronic pain. Intravenous lidocaine has peripheral and central mediated analgesic, anti-inflammatory and anti-hyperalgesic properties. Intravenous lidocaine infusion therapy (IVLT) has been shown to be effective in the management of acute and chronic pain in adults. This chapter will present the rational for IVLT in pediatric pain management with emphasis on preventative multimodal therapy in acute pain and the multidisciplinary treatment approach in chronic pain. Large multi-centre randomised controlled trials are required to provide the evidence-base to confirm that IVLT is indeed an effective and safe treatment option in acute preventative multimodal analgesia and as an adjunct in the multidisciplinary care of chronic pain in the pediatric population. Keywords

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“…Lidocaine can be also given intravenously exerting analgesic effects [128]. Several studies have investigated the effect of local anesthetics on immune system.In vitro, lidocaine inhibits the IL-8 and IL-1β release [129,130] from epithelial cells, the IL-1β secretion from mononuclear cells and neutrophil function [130], the phagocytosis [130,131], and the migration of leukocytes [130,132]. It attenuates the formation of reactive oxygen metabolites [133], and the release of leukotrienes, , and histamine [135].…”

mentioning

confidence: 99%

Anesthesia, cytokines and cancer recurrence

Kitamura¹,

Biaso²,

Ingelmo

et al. 2015

Glob Anesth Perioper Med

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Cytokines are essential mediators for the regulation of both innate and acquired immunity and hematopoiesis. They modulate immune cell signaling, activation, adhesion and functioning. They regulate the individual response to several insults such as infection, inflammation, trauma, and pain. Moreover, the balance between pro-inflammatory and anti-inflammatory cytokines is critical for the evolution of surgical complications and tumor progression.Several drugs, including anesthetic agents, influence cytokines secretion. Opioids, inhalational agents, intravenous and local anesthetics have shown different effects on immune system and cytokine expression. Therefore, anesthesia may play an important role in postoperative recovery and outcome of cancer patients.The aim of the present article is to review the main role of some important cytokines and the effect of anesthesia techniques and drugs on their secretion. Furthermore, current clinical evidence regarding the effects of anesthesia on cancer recurrence will be discussed. Cytokines and immune systemCytokines are proteins expressed in both innate and acquired immune system and are often named according to the secreting cells (i.e., lymphocytes, interleukins, etc.). They are essential mediators of the natural (non-specific, innate) immunity, which is the initial step of the inflammatory response. They also play a pivotal role during the specific immunity, which occurs after exposure to antigens, as they regulate lymphocyte and leukocyte activation, growth and differentiation, and the immune-mediated inflammation [1].The cytokines have different structures, but also common aspects, which are summarized in Table 1.The aim of the present article is to review the main role of some important cytokines and the effect of anesthesia techniques and drugs on their secretion. Cytokines receptorsThe cytokines receptors are formed by one or more transmembrane proteins: the extracellular portion binds the cytokine, whereas the cytoplasmic part starts the signal cascade. Based on the extracellular portion, they are divided in five categories. 1) Type I receptors, which have four α-helical stands and contain four cysteine residues and the amino acid motif tryptophanserine-X-tryptophan-serine (WSXWS).2) Type II receptors, structurally similar to Type I receptors, but without the sequence WSXWS. Cytokines functionProvided that the same cytokine may be produced during both innate and acquired immunity response, cytokines can be classified according to their functions: 1)Cytokines regulating the innate immunity and secreted by stimulated macrophages; 2)Cytokines regulating the acquired immunity and secreted by lymphocytes; 3)Cytokines stimulating the hematopoiesiss and secreted by bone marrow, leucocytes and other cells. Common aspects of CytokineTheir secretion is brief and limited in time Cytokine expressed during the innate immunity response Tumor necrosis factor (TNF-α, TNF-β)The TNF is responsible for the initial phase of acute inflammatory response, especially against ...

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Lidocaine inhibits secretion of IL-8 and IL-1βand stimulates secretion of IL-1 receptor antagonist by epithelial cells

Cited by 73 publications

References 40 publications

Clinical features and management of equine post operative ileus (POI):Survey ofDiplomates of theAmericanColleges ofVeterinaryInternalMedicine (ACVIM),VeterinarySurgeons (ACVS) andVeterinaryEmergency andCriticalCare (ACVECC)

Clinical features and management of equine post operative ileus (POI):Survey ofDiplomates of theAmericanColleges ofVeterinaryInternalMedicine (ACVIM),VeterinarySurgeons (ACVS) andVeterinaryEmergency andCriticalCare (ACVECC)

A Review of Intravenous Lidocaine Infusion Therapy for Paediatric Acute and Chronic Pain Management

Anesthesia, cytokines and cancer recurrence

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