Lidocaine-loaded fish scale-nanocellulose biopolymer composite microneedles

Abstract

Microneedle (MN) technology has emerged as an effective drug delivery system, and it has tremendous potential as a patient friendly substitute for conventional methods for transdermal drug delivery (TDD). In this paper, we report on the preparation of lidocaine-loaded biodegradable microneedles, which are manufactured from fish scale-derived collagen. Lidocaine, a common tissue numbing anaesthetic, is loaded in these microneedles with an aim of delivering the drug with controlled skin permeation. Evaluation of lidocaine permeation in porcine skin has been successfully performed using Franz diffusion cell (FDC) which has shown that the drug permeation rate increases from 2.5 to 7.5% w/w after 36 h and pseudo steady state profile is observed from 5.0 to 10.0% w/w lidocaine-loaded microneedle. Swelling experiments have suggested that the microneedles have negligible swellability which implies that the patch would stick to the tissue when inserted. The experiments on MN dissolution have depicted that the lidocaine loaded in the patch is lower than the theoretical loading, which is expected as there can be losses of the drug during initial process manufacture.

Versatile Application of Nanocellulose: From Industry to Skin Tissue Engineering and Wound Healing

“…In the field of local anesthetics, lidocaine was incorporated into bacterial cellulose in order to reduce pain, especially in burn wounds, and thus to improve the wound healing [132]. Another system developed for lidocaine delivery was based on biodegradable microneedles manufactured from bacterial cellulose and fish scale–derived collagen [36]. A further useful modification of bacterial cellulose is the introduction of glycerin.…”

“…Cellulose nanostructures, especially nanofibrils, can be further assembled into bigger two-dimensional (2D) and three-dimensional (3D) micro- and macro-structures. Two-dimensional structures include membranes and films in the self-supporting form [5,33] or in the form of material coatings [34,35], while 3D structures include microparticles, such as microneedles [36] and porous microbeads [37,38], and macroscopic matrices, such as porous aerogels and hydrogels, foams, and sponges [39,40,41,42].…”

A systematic review of carbohydrate-based microneedles: current status and future prospects

“…Carbohydrates play a quintessential role in the fabrication of MNs, and thus form the emphasis of this review. Carbohydrates, such as sugars, hyaluronic acid [ 44 , 45 ], cellulose [ 46 , 47 ], and chemically modified methacrylate hyaluronic acid [ 48 ], carboxymethylcellulose [ 49 , 50 ], are utilized alone, in a blend, or as a composite. They are similar to the extracellular matrix and are simply recognized and accepted by the human body [ 51 ].…”

Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case

“…They justified that the release was not in the seconds range then it may not be considered as a fast release system. They also argued that this behavior might be dose dependent [51]. To predict the delivery of lidocaine from the prepared hydrogels a fundamental understanding of the mechanisms controlling its release is necessary.…”