Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case

Favatela, Florencia; Horst, María Fernanda; Bracone, Melina Ethel; Gonzalez, Jimena Soledad; Álvarez, Vera A.; Lassalle, Verónica Leticia

doi:10.1016/j.jddst.2020.101886

Cited by 15 publications

(12 citation statements)

References 54 publications

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“…The analysis of swelling behavior of PMNC/MN-L samples was performed in PB 6.8 at 37°C (as a simulation of buccal environment [18] or pH environment of human intestines [19]) until equilibrium state was reached. Dry discs of PMNC/MN-L samples were first weight (m 0 , g) and then immersed into 100 ml of PB 6.8 and left to swell.…”

Section: Methodsmentioning

confidence: 99%

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Dual responsive hybrid hydrogels for controlled release of local anesthetic

Markovič

Šešlija

Panic

et al. 2022

procteh

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Inteligent hydrogels, such as pH sensitive hydrogels based on poly(methacrylic acid) (PMAA) are widely used for targeted drug delivery. Still, PMAA lack of good mechanical properties often limits its application. In order to overcome this limitation nanocellulose (NC) was extracted from wood waste material and then added to PMAA because NC is biocompatible, non-toxic and has excellent mechanical properties. Further, carboxymethyl cellulose (CMC) (cellulose derivate widely used for controlled release of drugs) was added. CMC can stabilize magnetite nanoparticles (MN) which is then also added. MN can significantly improve mechanical properties of hydrogels and also possess magnetic properties due to which MN can be used for targeted drug delivery. The as-prepared material can protect drug, deliver it to the site of action, control its release rate and enable in that way its efficient application with reduced side effects. Local anesthetic - lidocaine hydrochloride (LH) is often administrated by injection which can induce severe side effects. This problem is solved in present study by encapsulating LH into hydrogels based on PMAA, NC, CMC and MN (PMNC/MN-L). PMNC/MN-L hydrogels were characterized by FTIR and SEM spectroscopies and single compressive tests and then their swelling behavior and LH release were analyzed. Present study offers unique approach for green synthesis of dual responsive hydrogels with improves properties and their application for controlled release of local anesthetic with reduced side effects.

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Section: Methodsmentioning

confidence: 99%

“…for Feed composition). Lidocaine hydrochloride (2 wt% in respect to total mass of final reaction mixture [18]) was then added and dissolved. In order to achieve complete neutralization of methacrylic acid, adequate amount of sodium hydroxide was added to the reaction mixture.…”

Section: Synthesis Of Pmnc/mn-l Samplesmentioning

confidence: 99%

Dual responsive hybrid hydrogels for controlled release of local anesthetic

Markovič

Šešlija

Panic

et al. 2022

procteh

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“…The low thermal and mechanical stability of GEL hydrogels has constrained their use in a variety of applications. However, by mixing GEL with other natural polymers such as NaCMC, and also using crosslinking agents such as glutaraldehyde (GTA), its thermal and mechanical stability can be improved (Khan and Anwar 2021;Liu et al 2022;Favatela et al 2021). GEL/NaCMC hydrogels can be modified according to the ratio of polymers and the amount of GTA for drug delivery under interstitial fluid conditions (pH = 5.5 and T = 37 °C).…”

Section: Introductionmentioning

confidence: 99%

Transdermal drug delivery system of lidocaine hydrochloride based on dissolving gelatin/sodium carboxymethylcellulose microneedles

et al. 2023

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In this study, it was aimed to introduce a transdermal drug delivery system with dissolving microneedles (DMNs) based on gelatin (GEL) and sodium carboxymethyl cellulose (NaCMC) for lidocaine hydrochloride (LidoHCl) delivery. Different ratios of GEL and NaCMC were mixed, loaded with an active agent of LidoHCl, and treated with glutaraldehyde (GTA) as a crosslinker agent. Prepared hydrogels were cast into a silicon mold. Hereby, microneedles (MNs) with 500 µm height, 35° needle angle, 40-µm tip radius, and 960-µm tip-to-tip distance were fabricated. Samples containing LidoHCl 40%, GEL/NaCMC 5:1 (wt/wt), and polymer/GTA ratio 3.1 (wt/wt) showed the highest drug release ability (t < 10 min) with proper mechanical properties in comparison with other samples. Due to the drug release in a short time (fewer than 10 min), this drug delivery system can be used for rapid local anesthesia for pain relief as well as before minor skin surgeries. Graphical Abstract

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“…Hydrogel based techniques were also used for controlled release as ophthalmic DDS. [3] These techniques discharge drug in confined network whose net size is directly related to hydration and polymer design (Figure 1ac). [4] Mathematical design had been prepared by investigators to measure drug release in controlled release system.…”

Section: Introductionmentioning

confidence: 99%

“…Osmotic pump technique had been used in past for controlled drug release in which pharmaceutical agents were discharged through one or more than one small pores in semipermeable membrane as a reaction of osmotic gradient. Hydrogel based techniques were also used for controlled release as ophthalmic DDS [3] . These techniques discharge drug in confined network whose net size is directly related to hydration and polymer design (Figure 1a–c) [4] …”

Section: Introductionmentioning

confidence: 99%

Nano‐Drug Carriers: A Potential Approach towards Drug Delivery Methods

et al. 2022

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Drugs are directly connected to the approaches by which they are administered and their delivery affects cellular uptake, biodistribution, toxicity, and excretion. Drug delivery methods are also necessary to be modified with the development of new therapeutic agents. This review summarizes the information about advancements in the field of drug delivery and mechanisms of drug action followed by factors affecting biocompatibility. Graphene, graphene oxide, mesoporous silica nanoparticles (MSNs), iron oxide nanoparticles, polyethylene glycol ligands and gold nanoparticles are prominent advancements in the field of drug delivery. These nanocarriers are engulfed by the cells through endocytosis followed by intracellular trafficking to reach the cytoplasm and their biocompatibility can be affected by various physicochemical parameters like surface charge, size, and shape. This review article may prove essential for the modification of drug delivery methods with the development of new therapeutic agents to eliminate the hurdles in near future.* Drug carrier should be physiologically active. * Visiting molecules security and loading should be high. * No drug release before reaching target point. * Cells should be capable of accepting drug agents efficiently. * There should be controlled release of drug agents at target point.In order to fulfill these conditions, various strategies had been planned to synthesize the drug delivery system. Liposome based nanoparticles, [7] dendrimers and polymer have been used for drug delivery operating under physical environment. [8] Recently inorganic nanoparticles based drug delivery and carbon nanotubes have opened a new area in this field. [9] Nanocarriers like gold, semiconductor nano crystal, silica based nanomaterials [10] are mostly researched and has become a promising candidate for this field. [11] Mesoporous silica nanoparticle having size less than 500 nm are very attractive as drug carrier because of pore volume, high surface area and changeable pore sizes. [12] They are being used as a vehicle for delivery of therapeutic agents. [13] Some gate-keepers are needed to trap the drug agents inside mesoporous silica nanoparticles surface. [14] Polydopamine is a good gate keeper for this purpose and has the capability to make different compatible materials like polymer, semiconductors and ceramics by personal polymerization of dopamine in hydrophilic solution. [15] This is a recognized gate keeper on mesoporous silica surface and is much sensitive towards pH. By covering surface with polydopamine, cargo is loaded at neutral pH and moves out at lower pH. [16] Bio-based substances are being utilized as an important element in DDS as they have the polysaccharide based nanocarriers which are dominating due to their low poisonous nature, constancy after loading the therapeutic agents and biodegradability. [17] Moreover, the use of polysaccharide based aerogel has been increasing in the medicinal industry because of lightweight material and good surface area. [18] DDS qualities are tune...

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Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case

Cited by 15 publications

References 54 publications

Dual responsive hybrid hydrogels for controlled release of local anesthetic

Dual responsive hybrid hydrogels for controlled release of local anesthetic

Transdermal drug delivery system of lidocaine hydrochloride based on dissolving gelatin/sodium carboxymethylcellulose microneedles

Nano‐Drug Carriers: A Potential Approach towards Drug Delivery Methods

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