Transdermal drug delivery system of lidocaine hydrochloride based on dissolving gelatin/sodium carboxymethylcellulose microneedles

Bahmani, Shabnam; Khajavi, Ramin; Ehsani, Morteza; Rahimi, Mohammad; Kalaee, Mohammadreza

doi:10.1186/s41120-023-00074-9

Cited by 7 publications

(1 citation statement)

References 69 publications

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“…Dissolving microneedles (DMNs), as fourth generation MNs, have been extensively studied due to their rapid onset of action, simple fabrication methods, high loading capacity, and superior biocompatibility. According to the literature, there have been several studies on lidocaine DMNs for dermal anesthesia. ,, Our previous work showed DMNs based on polyvinylpyrrolidone (PVP), a water-soluble polymer, could completely dissolve in the skin; however, the poor mechanical strength and high moisture absorption of PVP limited its application . To overcome these drawbacks, hybrid matrix materials consisting of PVP and a cross-linked network of methacrylated chondroitin sulfate (CS), prepared by the reaction of CS with methacrylic anhydride (MA), were developed thereafter .…”

Section: Introductionmentioning

confidence: 99%

A Bilayer Microneedle for Modulated Sequential Release of Adrenaline and Lidocaine for Prolonged Local Anesthesia

Xia,

Xu,

Luo

et al. 2024

ACS Appl. Bio Mater.

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Chronic pain emerges as a major global health issue, significantly impacting individuals' health and quality of life. In this study, we designed a bilayer microneedle loaded with lidocaine nanocomposites in the inner layer and adrenaline (Adr) in the outer layer (HCP MNs) for modulated sequential release to achieve prolonged local anesthesia. The obtained HCP MNs featured an intact structure with adequate mechanical strength for efficient skin penetration. The bilayer structure of MNs was evidenced by loading two fluorescent dyes in each layer. Furthermore, these HCP MNs were capable of inducing rapid as well as prolonged local anesthetic effects in guinea pigs. Hence, the bilayer MN coloaded with Adr and lidocaine nanocomposite serves as a promising transdermal delivery platform for chronic pain management.

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Section: Introductionmentioning

confidence: 99%

A Bilayer Microneedle for Modulated Sequential Release of Adrenaline and Lidocaine for Prolonged Local Anesthesia

Xia,

Xu,

Luo

et al. 2024

ACS Appl. Bio Mater.

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Toward a solid microneedle patch for rapid and enhanced local analgesic action

Liu,

Zhao,

Liang

et al. 2024

Drug Deliv. and Transl. Res.

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Analgesic creams nd widespread application as adjuncts for localized anesthesia prior to surgical procedures. Nevertheless, the onset of analgesic action is protracted due to the skin barrier's inherent characteristics, which necessitates prolonged intervals of patient and clinician waiting, consequently impinging upon patient compliance and clinician work ow e ciency. In this work, a biodegradable microneedles (MNs) patch was introduced to enhance the transdermal administration of lidocaine cream to achieve rapid analgesia through a minimally invasive and conveniently accessible modality. The polylactic acid (PLA) MNs were mass-produced using a simple hot-pressing method and served the purpose of creating microchannels across the skin's surface for rapid absorption of lidocaine cream.Optical and electron microscopes were applied to meticulously scrutinize the morphology of the fabricated MNs, and the comprehensive penetration tests involving dynamometer, Optical Coherence Tomography (OCT) and animal skins demonstrated the robust mechanical strength of PLA MNs for successful transdermal penetration. The behavioral pain sensitivity tests on living rats revealed that the MNs-assisted lidocaine treatment expeditiously accelerated the onset of action and substantially enhanced the e cacy of localized anesthesia. Furthermore, different treatment protocols encompassing the sequence of drug application relative to MNs treatment, MNs dimensions, and the frequency of MNs insertions exhibited noteworthy in uence on the resultant local anesthesia e cacy. Together these results demonstrated that the lidocaine cream followed by diverse PLA MNs treatments would be a promising strategy for rapid clinical local anesthesia with wide-ranging applications.

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Lidocaine-Loaded Iontophoresis-Driven Fiber-Based Microneedle Patch for Controllable and Long-Lasting Transdermal Local Analgesia

Wang,

Shi,

Wang

et al. 2024

Adv. Fiber Mater.

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The acute pain induced by clinical procedures, such as venipuncture, dental operations, and dermatological treatments, as well as postoperative pain, drives the advancement of anesthetic techniques aimed at alleviating discomfort. This situation underscores the ongoing significance of effective pain management strategies within the field of anesthesia. This paper presents an integrated iontophoresis (ITP)-driven fiber-based microneedle patch (IFMP) regulated by a smartphone for controllable, long-lasting lidocaine transdermal delivery. The IFMP integrates pure cotton fiber canvas-based dissolving microneedles (MNs) with ITP into a patch, with the MNs tips and gel layers significantly increasing the drug-loading capacity, achieving a one-step drug administration strategy of “dissolution, diffusion, and ITP.” Lidocaine is released via the microchannels of MNs by passive diffusion. Additionally, an electric current initiates active ITP for lidocaine delivery, creating synergy. User-requirement-based drug release by precisely modulating electrical signals in rat pain models is described herein. A smartphone application enables precise dosage control. It offers three different delivery modes: single-dose, pulse delivery, and sustained-release, ensuring rapid onset, and long-lasting pain relief. This versatility makes the system suitable for various pain conditions. The IFMP represents a promising system for patient-controlled local analgesia treatment, enabling active and long-term local self-controlled pain management in a safe and regulated manner. Graphical Abstract The iontophoresis-driven fiber-based microneedle patch combines fiber-based dissolving microneedles with iontophoresis, facilitating controlled lidocaine release through diffusion and electrical activation for enhanced effect. Precise modulation of electrical signals allows user-requirement-based drug release in rat pain models. A smart application supports precise dosing in single-dose, pulse, or sustained-release modes, ensuring efficient and prolonged pain management.

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Transdermal drug delivery system of lidocaine hydrochloride based on dissolving gelatin/sodium carboxymethylcellulose microneedles

Cited by 7 publications

References 69 publications

A Bilayer Microneedle for Modulated Sequential Release of Adrenaline and Lidocaine for Prolonged Local Anesthesia

A Bilayer Microneedle for Modulated Sequential Release of Adrenaline and Lidocaine for Prolonged Local Anesthesia

Toward a solid microneedle patch for rapid and enhanced local analgesic action

Lidocaine-Loaded Iontophoresis-Driven Fiber-Based Microneedle Patch for Controllable and Long-Lasting Transdermal Local Analgesia

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