Given smooth manifolds $$M_1,\ldots , M_n$$
M
1
,
…
,
M
n
(which may have a boundary or corners), a smooth manifold N modeled on locally convex spaces and $$\alpha \in ({{\mathbb {N}}}_0\cup \{\infty \})^n$$
α
∈
(
N
0
∪
{
∞
}
)
n
, we consider the set $$C^\alpha (M_1\times \cdots \times M_n,N)$$
C
α
(
M
1
×
⋯
×
M
n
,
N
)
of all mappings $$f:M_1\times \cdots \times M_n\rightarrow N$$
f
:
M
1
×
⋯
×
M
n
→
N
which are $$C^\alpha $$
C
α
in the sense of Alzaareer. Such mappings admit, simultaneously, continuous iterated directional derivatives of orders $$\le \alpha _j$$
≤
α
j
in the jth variable for $$j\in \{1,\ldots , n\}$$
j
∈
{
1
,
…
,
n
}
, in local charts. We show that $$C^\alpha (M_1\times \cdots \times M_n,N)$$
C
α
(
M
1
×
⋯
×
M
n
,
N
)
admits a canonical smooth manifold structure whenever each $$M_j$$
M
j
is compact and N admits a local addition. The case of non-compact domains is also considered.