Objectives: This study investigates the optimization of reinforced concrete flat slabs and establishes a relationship between span, live load, and material costs. Methods: The study used the direct design method per Saudi Building Code limitations, iterative design, and pattern search methods to establish a mathematical model that prescribes the span-cost relationship. The study conducted variable live loading tastings and cost estimates on multiple flat slab panels with distinct dimensions. Findings: The results showed that slab material unit cost increases significantly with span while live load had little impact. Material costs included concrete, steel, and forms which compose 36%, 52%, and 12%, respectively of the total. Each increment in span by 1 meter raises slab material unit cost by 19% starting form 4 meters span as a baseline. Increasing live load by 1 kN/m 2 increase cost by roughly 2% for square panels and 1% for rectangular ones. However, results proved that using 1:1 panel dimension is more economical than panels with 2:1 ratio. Novelty: The study provided a mathematical model to estimate flat slab cost more accurately in preliminary estimations before the design phase.