Masonry is a widespread construction system, but it is very prone to seismic damage. In Italy, almost 60% of residential buildings are constructed in masonry, and 85% of them were built before 1980 without specific design regulation; thus, there is the need for large-scale vulnerability assessment. When large stocks of residential buildings (>50–100) are involved, also in historical centers, seismic vulnerability analysis must resort to simplified and computer-aided methods. Among these, the best known analyze (i) the overall shear strength normalized to the weight; (ii) the activation coefficient of local mechanisms; and (iii) dimensionless indexes obtained from the weighted sum of scores associated with a set of vulnerability factors. The Vulnus procedure proposes a vulnerability function in the 3D space defined by these factors, namely VIP, VOP and VV. The ‘mechanical’ indexes VIP and VOP determine the capacity of the building (in-plane and out-of-plane, respectively), whereas the ‘empirical’ index VV sets the pace at which this capacity is reached and the uncertainty in its final value. The procedure considers the confidence level of the indexes by means of fuzzy set theory, which enables expression of the vulnerability in linguistic terms (e.g., ‘high’ or ‘low’), as well as through a fragility curve. In this paper, a web toolbox based on the Vulnus procedure, namely, Vulnus Web, is proposed. It enables the central archiving of data, improved interaction with the program code and a wider dissemination. The new procedure was applied to a masonry building hit by the Central Italy 2016 earthquake; both the vulnerability level assessed numerically and the damage prediction were in good accordance with the actual seismic performance of the building.