Life-threatening acute adverse cutaneous drug reactions

Wolf, Ronni; Orion, Edith; Marcos, Batsheva; Matz, Hagit

doi:10.1016/j.clindermatol.2004.06.012

Cited by 153 publications

(128 citation statements)

References 141 publications

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“…Severe forms are rare, with an es mated propor on of 2%. 12,13 The course can be fatal in 0.2 to 29.3% of cases requiring hospitaliza on when a severe evolu on is predicted. 12 The recogni on of the dermatological reac on pa erns and the exclusion of diff eren als are of primary importance for which history and clinical examina on form the cornerstone of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Patterns and Outcomes of Cutaneous Adverse Drug Reactions in a Hospital Based Study

Paudel¹,

Parajuli²,

Pokhrel³

2017

Nepal J Dermatol Venereol & Leprol

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Section: Discussionmentioning

confidence: 99%

Patterns and Outcomes of Cutaneous Adverse Drug Reactions in a Hospital Based Study

Paudel¹,

Parajuli²,

Pokhrel³

2017

Nepal J Dermatol Venereol & Leprol

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“…Patients with more severe ACDRs (eg TEN) may need prompt hospitalisation. 31 An alternative class of antidepressant to SSRIs (and possibly even to SNRIs) should be considered if there has been an ACDR to an SSRI.…”

Section: Managementmentioning

confidence: 99%

SSRI‐induced severe adverse cutaneous reaction – a case report

Byrne¹,

Arkell²,

Bandi³

2017

Prog Neurol Psychiatry

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As selective serotonin re‐uptake inhibitors (SSRIs) are commonly prescribed, less common side‐effects such as severe adverse cutaneous drug reactions (ACDRs) can be seen more frequently than with less frequently prescribed antidepressants. Sertraline is among the better tolerated SSRIs. Here, we describe a case of a sertraline‐induced severe ACDR in a patient with depressive symptoms and cognitive impairment. The selection of an appropriate antidepressant proved challenging. A review of recent literature on the clinical and temporal presentation of SSRI‐induced ACDRs is presented with management strategies.

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“…The average incidences of SJS and TEN are estimated at 1.2 to 6 and at 0.4 to 1.2 cases per million, per year respectively. An early diagnosis, the withdrawal of suspected drugs and a proper management may improve the prognosis of SJS and TEN [5]. Females are affected more commonly than males in the ratio of 1.5:1 and this ratio increases with age [6].…”

Section: Discussionmentioning

confidence: 99%

Can Vitamin B-Complex Aggravate the Carbamazepine Induced Toxic Epidermal Necrolysis?

Fegade

Bhounsule²,

Pereira³

2012

JCDR

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Toxic Epidermal Necrolysis (TEN), which is also known as Lyell's syndrome, is a widespread, life-threatening, mucocutaneous disease that is particularly observed secondary to drugtaking and less commonly secondary to infections and immunization. Carbamazepine is associated with benign pruritic rash in 10-15% of the patients, but the life threatening dermatological syndromes like exfoliative dermatitis, erythema multiforme, the Stevens-Johnson Syndrome (SJS) and TEN are rarely seen with the carbamazepine treatment.The 32 year old female suffering from chronic backache, who was prescribed carbamazepine along with an intravenous combination of vitamin B-complex and calcium, developed fever, cough and mucocutaneous manifestations of TEN after 15 days of the treatment. She was treated in the hospital with systemic steroids, intravenous immunoglobulins, antibiotics, intravenous fluids and supportive care. In spite of the above treatment, the patient could not survive for more than seven days.

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Life-threatening acute adverse cutaneous drug reactions

Cited by 153 publications

References 141 publications

Patterns and Outcomes of Cutaneous Adverse Drug Reactions in a Hospital Based Study

Patterns and Outcomes of Cutaneous Adverse Drug Reactions in a Hospital Based Study

SSRI‐induced severe adverse cutaneous reaction – a case report

Can Vitamin B-Complex Aggravate the Carbamazepine Induced Toxic Epidermal Necrolysis?

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