Patterns and Outcomes of Cutaneous Adverse Drug Reactions in a Hospital Based Study

Paudel, Udaya Raj; Parajuli, Surya Bahadur; Pokhrel, Dinesh Binod

doi:10.3126/njdvl.v15i1.18051

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…A higher incidence of serious CADR has been reported by other authors 5,7 . We observed that SJS was the most common type of serious CADR, similar to the observation of other authors 9,22 . Anticonvulsant was the commonest drug group involved in serious CADR in our study.…”

Section: Original Articlesupporting

confidence: 92%

Cutaneous Adverse Drug reactions: A Four-Year Study from Western Nepal

Neupane

Basnet

2018

J. Gandaki Med. Coll. Nepal

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Background: Cutaneous adverse drug reactions (CADRs) range from minor reactions to several life threatening complications. Objectives: To study the clinical spectrum of cutaneous adverse drug reactions, determine the causative drugs responsible for the reactions and to assess the preventability.Methods: The study was carried out in the Department of Dermatology of Gandaki Medical College Teaching Hospital from June 2011 to June 2015. All the patients attending the Dermatology Outpatient Department and the patients admitted in the wards with suspected cutaneous adverse drug reactions to systemic drugs were included in the study. A detailed clinical history, including the history of drug intake was noted. Each case was assessed for its causality by using the WHO definitions. Data analysis was done using SPSS software.Results: There were 102 patients in total. The mean age of the patient was 32 ±15.7 years. Maximum patients belonged to the 21 to 30 years age group. There were 59 female patients and 43 male patients. Severe type of cutaneous adverse drug reactions was noted in 7.8% of patients. Antibiotics were responsible for most of the cutaneous adverse drug reactions. Cefixime was the most commonly incriminated drug. Exanthematous drug reaction was the most common type seen in 45%. Stevens-Johnson syndrome was the commonest type noted among the serious adverse drug reactions. Drug preventability was noted in 6% of patients.Conclusions: The commonest type of CADR noted was exanthematous type. Antibiotics were the commonest drug group involved in CADR. Six percent of CADR were preventable. J-GMC-N | Volume 11 | Issue 01 | January-June 2018, Page: 21-26

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Section: Original Articlesupporting

confidence: 92%

Cutaneous Adverse Drug reactions: A Four-Year Study from Western Nepal

Neupane

Basnet

2018

J. Gandaki Med. Coll. Nepal

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“…This was similar to studies conducted by Paudel et al, (Nepal) and Ines Zaara et al, (Tunisia, North Africa). 18,21 On the contrary, most of the studies done in different parts of India and also in other countries reported antimicrobials to be the commonest drug followed by NSAIDS and anticonvulsants (Table 5). 7,[12][13][14][15][16]19 High use of antibiotics and analgesics procured OTC could be the reasons.…”

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confidence: 99%

Analysis of cutaneous adverse drug reactions in a tertiary care hospital in South Tamil Nadu

Murthy¹,

K.²,

Palanivel

et al. 2022

Int J Basic Clin Pharmacol

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Background: Cutaneous adverse drug reactions (CADRs) are among the most frequently reported adverse drug reactions (10 to 30%) with overall incidence of 6.2/1000 cases in India and 8% of hospitalisation among Dermatology inpatients. The aim was to analyse the CADRs with reference to its prevalence, causative drugs, morphological patterns, polypharmacy and drug reaction severity by Hartwig’s severity assessment scale.Methods: This study was a retrospective study done in the Department of Dermatology, Venereology and Leprosy (DVL) over a period of 5 years (2015 to 2019) from CADR registers. Mean, standard deviation and chi square test were used for statistical analysis. P≤0.05 was considered as statistically significant.Results: A total of 134 cases of CADRs were encountered which comprised 0.2% (2/1000) of total OP census with equal gender ratio and involved most commonly the younger adults. The drug groups mainly responsible were anticonvulsants (24.7%) followed by non-steroidal anti-inflammatory drugs (NSAIDS) (22.5%), antibiotics (20.9%) followed by antiretrovirals (ART) and antituberculous drugs (ATT). The common morphological patterns were acute exanthem (32.2%), exfoliative dermatitis (14.9%) and toxic epidermal necrolysis (14.2%). Over the counter drugs accounted for 25.6% of cases. Around 38.1% were on polypharmacy. In this study, 15.7% had mild CADR, 53.7% had moderate and 30.6% had severe drug reactions with 2.2% mortality based on the Hartwig’s severity assessment scale. Commonest cause of severe CADRs was anticonvulsants and benign CADRs was NSAIDS.Conclusions: Proper history taking and documentation of data, recollection of sequence of events by the patient and drug re-challenge will help us in deciding the causative drug preventing further occurrence.

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Bibliometric analysis of adverse drug reactions and pharmacovigilance research activities in Nepal

Shrestha

Danekhu

et al. 2020

Therapeutic Advances in Drug Safety

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Background: Bibliometric analyses have been used previously to study the measures of quality and impact of research performed in several health-related areas such as adverse drug reactions (ADRs) and pharmacovigilance (PV), etc. This method can assess the research performance of publications quantitatively and statistically. There is no evidence of bibilometric studies analyzing ADRs and PV from Nepal. Therefore, the present study aimed to assess scientific output on ADRs and PV-related research activities in Nepal using a bibliometric analysis of publications from 2004 January to December 2018, that is, 15 years. Methods: A systematic search was conducted in PubMed, Web of Science, Google Scholar, Scopus and Nepal Journal Online (NepJOL) databases. ‘Adverse Drug Reactions‘ or ‘ADRs‘ or ‘ADR‘ or ‘Adverse drug reaction‘ or ‘AE‘ or ‘Adverse Event‘ or ‘Drug-Induced Reaction‘ or ‘Pharmacovigilance‘ or ‘PV‘ and ‘Nepal‘. The search covered 15 years (January 2004 to December 2018) of study on ADRs and PV in Nepal. Only articles retrieved from databases were included, whereas published/unpublished drug bulletins, pharmacy newsletters and thesis were excluded. The articles thus retrieved were recorded, and thereafter analyzed. Word count code was used for the analysis of keywords used in the retrieved articles. Results: A total of 124 articles were retrieved, with the highest rate of publications in 2006 and 2007, with 16 papers each. Among the articles, 10 (8.1%) were published in Kathmandu University Medical Journal (KUMJ). Single papers were published in 38 different journals. Brief reports (1.6%), case reports (31.2%), case series (0.8%), education forums (0.8%), letters to the editor (5.6%), original research articles (41.9%), review articles (9.7%), short communications and short reports (8.1%) on ADRs and PV were recorded. Out of 124 papers, 52 (41.9%) were original research publications. The majority (74.1%) of research was done in the category of ADR incidence, types, prevention, and management, followed by policy and suggestions for strengthening national and regional pharmacovigilance centers of Nepal (14.5%). Conclusions: During the study years, there was an increase in scientific publications on drug safety. A total of 124 published articles were found during bibliometric analysis of ADRs and PV research activities in Nepal.

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Patterns and Outcomes of Cutaneous Adverse Drug Reactions in a Hospital Based Study

Abstract: Introduction : Drug reactions are one of the common reasons for admission in the Dermatological beds. Data on the culprit drugs and patterns of reaction are very scarce in Nepal.

Cited by 3 publications

References 19 publications

Cutaneous Adverse Drug reactions: A Four-Year Study from Western Nepal

Cutaneous Adverse Drug reactions: A Four-Year Study from Western Nepal

Analysis of cutaneous adverse drug reactions in a tertiary care hospital in South Tamil Nadu

Bibliometric analysis of adverse drug reactions and pharmacovigilance research activities in Nepal

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