Lifelong protection mediated by stem cell-like CD8+ T memory subset cells (Tscm) induced by vaccination

Morrot, Alexandre

doi:10.21037/atm.2016.05.38

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…At the same time, it is worth noting that a single treatment method cannot effectively eliminate tumor cells. Immune cell therapy should be combined with PD-1 monoclonal antibody, CTLA-4 monoclonal antibody or radiotherapy, chemotherapy and other treatment methods, so that patients can get better efficacy (165). T SCM has long existed in the HIV-1 virus reservoir, so future research is necessary to determine whether the low virus accumulation in T SCM cells represents a significant feature of HIV-1 infection.…”

Section: Discussionmentioning

confidence: 99%

Immunotherapeutic Potential of T Memory Stem Cells

Yang

et al. 2021

Front. Oncol.

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Memory T cells include T memory stem cells (TSCM) and central memory T cells (TCM). Compared with effector memory T cells (TEM) and effector T cells (TEFF), they have better durability and anti-tumor immunity. Recent studies have shown that although TSCM has excellent self-renewal ability and versatility, if it is often exposed to antigens and inflammatory signals, TSCM will behave as a variety of inhibitory receptors such as PD-1, TIM-3 and LAG-3 expression, and metabolic changes from oxidative phosphorylation to glycolysis. These changes can lead to the exhaustion of T cells. Cumulative evidence in animal experiments shows that it is the least differentiated cell in the memory T lymphocyte system and is a central participant in many physiological and pathological processes in humans. It has a good clinical application prospect, so it is more and more important to study the factors affecting the formation of TSCM. This article summarizes and prospects the phenotypic and functional characteristics of TSCM, the regulation mechanism of formation, and its application in treatment of clinical diseases.

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Section: Discussionmentioning

confidence: 99%

Immunotherapeutic Potential of T Memory Stem Cells

Yang

et al. 2021

Front. Oncol.

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“…More importantly, multidimensional scaling analysis demonstrated that Tscm cells were the most similar to naïve T cells because there were only 75 different genes between them compared to 157 and 226 for Tcm and Tem cells (3), thus which could continuously differentiate into Tcm, Tem and CTL under antigen stimulation. Because of the potent ability of Tscm, the Tscm induction becomes an important indicator for estimating various vaccines because of its special characteristics, such as the yellow fever vaccine YF-17D (26) and the AIDS experimental vaccine RV144 (27). This may bring a new hope to solve existing problems in current rising T cell adoptive immunotherapy, where TCR or CAR gene engineered effector T cells easily become exhaustion and are hard to survive for a long time (28).…”

Section: Discussionmentioning

confidence: 99%

CD40 Accelerates the Antigen-Specific Stem-Like Memory CD8+ T Cells Formation and Human Papilloma Virus (HPV)-Positive Tumor Eradication

et al. 2020

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Antigen-specific stem-like memory CD8 + T cells (Tscm) have a series of stem cell characteristics, including long-term survival, self-renewal, anti-apoptosis and persistent differentiation into cytotoxic T cells. The effective induction of tumor-specific CD8 + Tscm could persistently eradicate tumor in pro-tumor hostile microenvironment. This study was to investigate the role of CD40 in HPV16-specific CD8 + Tscm induction and its anti-tumor function. We found that CD40 activation accelerated vaccine-induced HPV16 E7-specific CD8 + Tscm formation. Comparing to other HPV-specific CD8 + T cells, CD8 + Tscm were found to be stronger and long-term anti-tumor function, in vivo and in vitro, even in the adoptive cellular transferring model. Furthermore, high frequencies of Tscm might prevent the HPV infection to move on to the development of cancer. And the CD40 effect on Tscm involved Wnt/β-catenin activation. Our study suggest that CD40 activation supports the generation of tumor-specific CD8 + Tscm, thus providing new insight into cancer immunotherapy.

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“…They are maintained at a constant size in the host repertoire due to its self-renewing capacity. Human memory stem T cells were shown to be multipotent in providing a potential reservoir for T cell memory throughout life (4). With the advent of T cell-based gene therapy, the possibility to monitor antigen-specific T cells and their in vivo dynamics and homeostasis has provided important insights on T cell persistence throughout the human lifespan.…”

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confidence: 99%

Lifelong protection mediated by stem cell-like CD8+ T memory subset cells (Tscm) induced by vaccination

Cited by 7 publications

References 11 publications

Immunotherapeutic Potential of T Memory Stem Cells

Immunotherapeutic Potential of T Memory Stem Cells

CD40 Accelerates the Antigen-Specific Stem-Like Memory CD8+ T Cells Formation and Human Papilloma Virus (HPV)-Positive Tumor Eradication

Human stem memory T cells (TSCM) as critical players in the long-term persistence of immune responses

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