Lifespan and disease predispositions in the Irish Wolfhound: A review

Urfer, Silvan R.; Gaillard, C.; Steiger, Andreas

doi:10.1080/01652176.2007.9695233

Cited by 25 publications

(19 citation statements)

References 53 publications

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“…In cats that died at 5 years of age or older, cats weighing less than 3 kg lived 1.7 years longer on average than cats weighing between 4 and 5 kg. A negative association between bodyweight and longevity has previously been reported in dogs (14) and was hypothesised to result from genetic and pathological effects induced by artificial selection for extremes of size and growth (50)(51)(52)(53). The bodyweight associations with longevity identified in the current study may have been partially confounded by breed and obesity effects that could be explored in future studies (46).…”

Section: Discussionmentioning

confidence: 78%

Longevity and mortality of cats attending primary care veterinary practices in England

O’Neill

Church

McGreevy

et al. 2014

Journal of Feline Medicine and Surgery

180

164

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Enhanced knowledge on longevity and mortality in cats should support improved breeding, husbandry, clinical care and disease prevention strategies. The VetCompass research database of primary-care veterinary practice data offers an extensive resource of clinical health information on companion animals in the UK. This study aimed to characterise longevity and mortality in cats and to identify important demographic risk factors for compromised longevity. Crossbred cats were hypothesised to live longer than purebred cats. 3Descriptive statistics were used to characterise the deceased cats. Multivariable linear regression methods investigated risk factor association with longevity in cats that died at or after 5 years of age.From 118,016 cats attending 90 practices in England, 4,009 cats with confirmed deaths were randomly selected for detailed study. Demographic characterisation showed that 3,660 (91.7%) were crossbred, 2,009 (50.7%) were female and 2,599 (64.8%) were neutered. The most frequently attributed causes of mortality in cats of all ages were trauma (12.2%), renal disorder (12.1%), non-specific illness (11.2%), neoplasia (10.8%) and mass lesion disorders (10.2%). Overall, the median longevity was 14.0 years (IQR 9.0-17.0; range 0.0-26.7). Crossbred cats had a higher median longevity than purebred cats (median (IQR) 14.0 years (9.1-17.0) versus 12.5 years (6.1-16.4), P < 0.001) but individual purebred cat breeds varied substantially in longevity. In cats dying at or after 5 years (n = 3,360), being crossbred, lower bodyweight, neutered and non-insured were associated with increased longevity. This study described longevity in cats and identified important causes of mortality and breed-related associations with compromised longevity.

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Section: Discussionmentioning

confidence: 78%

Longevity and mortality of cats attending primary care veterinary practices in England

O’Neill

Church

McGreevy

et al. 2014

Journal of Feline Medicine and Surgery

180

164

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“…Records of Irish Wolfhounds, large dogs first bred in Ireland, date back to 391 A.D. [8]. These dogs only live 7 years on average [7], and are particularly susceptible to osteosarcoma, even as compared to other large, fast-growing breeds that are typically prone to this cancer [10]. Finally, the large Newfoundland breed was developed in Newfoundland, Canda in the early 1600s [8] and live 9 years on average [7].…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms within the Telomerase Reverse Transcriptase gene (TERT) in four breeds of dogs selected for difference in lifespan and cancer susceptibility

et al. 2014

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BackgroundEnzymatic activity of Telomerase Reverse Transcriptase (TERT) is important in maintaining the telomere length and has been implicated in cancer and aging related pathology. Since cancer susceptibility as well as longevity of dogs vary between breeds, this study involved sequencing the entire TERT gene of Canis familiaris from DNA samples obtained from forty dogs, with ten dogs each of four breeds: Shih Tzu, Dachshund, Irish Wolfhound, and Newfoundland, each with different life expectancies and susceptibility to cancer.ResultsWe compared the sequences of all forty individuals amongst one another and with the published sequence of canine TERT, and analyzed relationships between members of the same or different breeds. Two separate phylogenetic trees were generated and analyzed from these individuals. Polymorphisms were found most frequently in intronic regions of the gene, although exonic polymorphisms also were observed. In many locations genotypes were observed that were either homozygous for the reference sequence or heterozygous, but the variant homozygous genotype was not observed.ConclusionsWe propose that these homozygous variants are likely to have adverse effects in dogs. It was also found that the polymorphisms did not segregate by breed. Because the four breeds chosen come from geographically and physiologically distinct backgrounds, it can be inferred that the polymorphic diversification of TERT preceded breed derivation.

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“…The severity of BP recurrence was indicated by the short intervals between episodes (median, 3 months) and the fact that approximately half of affected dogs eventually died or were euthanized because of BP. However, most of the affected IWHs reached average life expectancy for this breed (reported mean age at death, 6.2‐8.2 years) despite suffering from repeated episodes of BP until death . A slight female predisposition was noted (8/11 were female), although this predisposition would need to be confirmed in larger studies.…”

Section: Discussionmentioning

confidence: 87%

Recurrent bacterial pneumonia in Irish Wolfhounds: Clinical findings and etiological studies

Viitanen

Lappalainen

Koho

et al. 2019

Veterinary Internal Medicne

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Background Increased incidence of bacterial pneumonia (BP) has been reported in Irish Wolfhounds (IWHs), and recurrence of BP is common. The etiology of recurrent pneumonia in IWHs is largely unknown. Objectives To describe clinical findings in IWHs with recurrent BP and investigate possible etiologies. Animals Eleven affected IWHs, 25 healthy IWHs, 28 healthy dogs of other Sighthound breeds, and 16 healthy dogs of other breeds. Methods Prospective cross‐sectional observational study. All affected IWHs underwent thorough clinical examinations including thoracic radiographs, thoracic computed tomography, electron microscopic evaluation of ciliary structure, and bronchoscopy and bronchoalveolar lavage fluid (BALF) cytology and culture. Serum and BALF immunoglobulin concentrations were measured using an ELISA method, and peripheral blood lymphocyte subpopulations were analyzed using flow cytometry. Esophageal function was assessed by fluoroscopy (n = 2). Results Median age of onset was 5.0 years (range, 0.4‐6.5 years), and when presented for study, dogs had experienced a median of 5 previous episodes of BP (range, 2‐6). The following predisposing factors to BP were detected: focal bronchiectasis (10/11), unilateral (2/9) and bilateral (1/9) laryngeal paralysis, and esophageal hypomotility (2/2). Local or systemic immunoglobulin deficiencies or primary ciliary defects were not detected. Conclusions and Clinical Importance Recurrent BP affects mostly middle‐aged and older IWHs without any evident immune deficit or primary ciliary defects. Focal BE was a frequent finding in affected dogs and likely contributed to the development of recurrent respiratory infections. Laryngeal and esophageal dysfunction identified in a minority of dogs may contribute to recurrent BP.

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Lifespan and disease predispositions in the Irish Wolfhound: A review

Cited by 25 publications

References 53 publications

Longevity and mortality of cats attending primary care veterinary practices in England

Longevity and mortality of cats attending primary care veterinary practices in England

Polymorphisms within the Telomerase Reverse Transcriptase gene (TERT) in four breeds of dogs selected for difference in lifespan and cancer susceptibility

Recurrent bacterial pneumonia in Irish Wolfhounds: Clinical findings and etiological studies

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