Lifestyle and Sporadic Colorectal Cancer in India

Sinha, Rajesh Kumar; Doval, Dinesh Chandra; Hussain, Showket; Kumar, Kapil; Singh, Shivendra; Basir, Seemi Farhat; Bharadwaj, Mausumi

doi:10.7314/apjcp.2015.16.17.7683

Cited by 19 publications

(9 citation statements)

References 26 publications

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“…The Cancer Genome Atlas reported no clear distinction of mRNA and miRNA expression levels between nonhypermethylated colon cancer and rectal tumors; however, some differences were found in gene expression patterns between the right colon and rectum [20]. However, several reports suggested a difference in the expression pattern of genes in colon and rectal tumors [17,[21][22] along with the significant differences in the mutation level of APC and KRAS mutation between colon and rectal cancer [23]. This indicates a mixed report on whether there exists a difference in the expression pattern of colon and rectal cancer.…”

Section: Discussionmentioning

confidence: 99%

GAPDH and PUM1: Optimal Housekeeping Genes for Quantitative Polymerase Chain Reaction-Based Analysis of Cancer Stem Cells and Epithelial-Mesenchymal Transition Gene Expression in Rectal Tumors

Vermani¹,

Kumar²,

Kumar³

2020

Cureus

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Section: Discussionmentioning

confidence: 99%

GAPDH and PUM1: Optimal Housekeeping Genes for Quantitative Polymerase Chain Reaction-Based Analysis of Cancer Stem Cells and Epithelial-Mesenchymal Transition Gene Expression in Rectal Tumors

Vermani¹,

Kumar²,

Kumar³

2020

Cureus

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“…In our patients, the median duration of symptoms was 4 months and the commonest symptom was rectal bleeding (56.5%) followed by pain (44%) and altered bowel habits (25.6%). Most studies have reported similar common symptoms in patients with CRC [23,25,26].…”

Section: Discussionmentioning

confidence: 99%

Colorectal Cancer in India: An Audit from a Tertiary Center in a Low Prevalence Area

Patil

Saklani

Gambhire

et al. 2017

Indian J Surg Oncol

162

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Colorectal cancer (CRC) is a common cancer worldwide with a low reported incidence in India. There is significant geographical variation in the incidence rates, and the presentation may also vary. There are few studies evaluating the clinical profile of CRC in Indian patients. We analyzed a prospective database maintained at the Tata Memorial Hospital, a referral cancer center in Mumbai, of consecutive patients with CRC between August 2013 and August 2014. We captured details regarding the demography, symptoms, pathology, stage, and treatment plan. The aim was to assess the demographic and clinical details of patients with CRC in India and compare it with those of the reported literature. Eight hundred new patients with CRC were seen in the colorectal clinic in one year. The mean age was 47.2 years. Sixty-five percent were males. Patients were symptomatic for an average period of 4 months prior to presentation. The commonest symptoms were rectal bleeding (57%), pain (44%), and altered bowel habits (26%). Thirteen percent of the patients had signet ring tumors. The median CEA (carcinoembryonic antigen) level was 5.8 ng/mL. Most patients had localized or locally advanced disease. Twenty-eight percent of the patients had metastatic disease with liver being the commonest site of metastases (14%) followed by peritoneum and lung. More than half of the patients received treatment with a curative intent. Colorectal cancer in India differs from that described in the Western countries. We had more young patients, higher proportion of signet ring carcinomas, and more patients presenting with an advanced stage. Inadequate access to healthcare and socioeconomic factors may play a role in some of these differences.

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“…Azeem et al [8] reported that spicy foods and tapioca increase colorectal cancer in the Asian population. In India, studies have shown that spicy foods, low-calorie meals, and alcohol consumption may increase the incidence and severity of colorectal cancer [9].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Colorectal Cancer in Korea: A Population-Based Retrospective Cohort Study

et al. 2019

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The incidence of colorectal cancer in Korea has recently increased, making it the second most common cancer in men and the third most common cancer in women. Risk factors for colorectal cancer have been studied worldwide, but risk factors specific for the Korean population have not been established. In this study, we investigated incidence trends and risk factors of colorectal cancer in Korea. Methods: A total of 8,846,749 subjects were included. Colorectal cancer incidence was investigated using Korea National Health Insurance Service claim data from 2004 to 2014. Colorectal cancer diagnoses were obtained by evaluating colorectal cancer diagnostic codes and the cancer registry for cost sharing. Risk factor identification for colorectal cancer was obtained from National Health Examination data from 2004 to 2005. Cox proportional hazard model statistical analysis was used to determine risk factors of colorectal cancer. Results: The incidence of colorectal cancer gradually increased from 2006 to 2014 (from 45.4/100,000 to 54.5/100,000). There was a predominance among men (1.47:1), but incidence trends were similar in both sexes. Old age, high body mass index, and no history of colonoscopy were identified as risk factors in both sexes. High fasting blood glucose, familial history of cancer, frequent alcohol intake, and current smoker were identified as risk factors, especially in men. Conclusion: The incidence of colorectal cancer has been increasing in Korea. Colonoscopy screening was a protective factor for colorectal cancer, and active use of colonoscopy may reduce incidence. Early diagnosis and care are important, particularly for the high-risk group.

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Lifestyle and Sporadic Colorectal Cancer in India

Cited by 19 publications

References 26 publications

GAPDH and PUM1: Optimal Housekeeping Genes for Quantitative Polymerase Chain Reaction-Based Analysis of Cancer Stem Cells and Epithelial-Mesenchymal Transition Gene Expression in Rectal Tumors

GAPDH and PUM1: Optimal Housekeeping Genes for Quantitative Polymerase Chain Reaction-Based Analysis of Cancer Stem Cells and Epithelial-Mesenchymal Transition Gene Expression in Rectal Tumors

Colorectal Cancer in India: An Audit from a Tertiary Center in a Low Prevalence Area

Risk Factors for Colorectal Cancer in Korea: A Population-Based Retrospective Cohort Study

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