Lifestyle and youthful looks

Gunn, David A.; Dick, Joanne L.; Heemst, Diana van; Griffiths, Cem; Tomlin, Cyrena C.; Murray, P. G.; Griffiths, Tamara; Ogden, Stephanie; Mayes, Andrew E.; Westendorp, Rudi G. J.; Slagboom, P. Eline; Craen, Anton J. M. de

doi:10.1111/bjd.13646

Cited by 25 publications

(18 citation statements)

References 45 publications

(74 reference statements)

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“…The mean estimate of the age for each participant was used as the participant’s perceived age. The method used for generating perceived age has been tested in terms of its reliability and validity previous to this study (Gunn et al, 2015; Gunn et al, 2008; Gunn et al, 2009). In this study, the perceived age rating had a Cronbach’s alpha of α = .97, representing excellent interrater reliability.…”

Section: Methodsmentioning

confidence: 99%

“…The co-twin study also showed that 40% of the variation in perceived age is due to nongenetic factors (Christensen et al, 2009). Therefore, it is assumed that lifestyle factors can have significant long-term effects on perceived age (Gunn et al, 2015). In particular, a high social status, being married, nonsmoking, and describing no depressive mood are significantly associated with a younger appearance in comparison with chronological age from a facial photograph (Rexbye et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Are Psychosocial Resources Associated With Perceived Facial Aging in Men?

Noser

Walther

Ehlert

2017

Gerontology and Geriatric Medicine

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Background: Looking younger than actual age has been related to a variety of health outcomes. Optimism, self-esteem, and relationship satisfaction are important psychosocial resources for mental health. Little is known about their relation with a younger facial appearance. Objective: This study analyzed whether these psychosocial resources are associated with a younger facial appearance and if their effects were mediated through mental health. Method: A sample of N = 223 self-reporting healthy men aged 40 to 75 years filled in questionnaires to assess optimism (Life Orientation Test–Revised), self-esteem (Multidimensional Self-Esteem Scale), relationship satisfaction (Relationship Assessment Scale), and mental health (Short-Form Health Survey). Five female raters estimated the visual age of each participant from a frontal face photograph. Results: Looking younger (compared with chronological age) was correlated with optimism, relationship satisfaction, and mental health. Mediation analyses and structural equation modeling indicated that mental health mediated the association between each psychosocial resource and a younger appearance. Discussion: The results emphasize the importance of promoting psychosocial resources and mental health in men 40+ for the maintenance of good health and the deceleration of facial aging.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Are Psychosocial Resources Associated With Perceived Facial Aging in Men?

Noser

Walther

Ehlert

2017

Gerontology and Geriatric Medicine

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“…Aging is a fundamental process of life in which there is a time‐dependent decline of physiological integrity and cellular function affecting all tissues (Gunn et al, ; López‐Otín, Blasco, Partridge, Serrano, & Kroemer, ; Makrantonaki et al, ). In skin, these changes can occur due to the passage of time (intrinsic aging) and may be accelerated by environmental factors, the principal one being exposure to ultraviolet radiation (extrinsic aging) (Jenkins, ; Pillai, Oresajo, & Hayward, ; Tsoureli‐Nikita, Watson, & Griffiths, ).…”

Section: Introductionmentioning

confidence: 99%

Osmolyte transporter expression is reduced in photoaged human skin: Implications for skin hydration in aging

et al. 2019

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Aging is characterized by the deterioration of tissue structure and function. In skin, environmental factors, for example, ultraviolet radiation (UVR), can accelerate the effects of aging such as decline in barrier function and subsequent loss of hydration. Water homeostasis is vital for all cellular functions and it is known that organic osmolyte transport is critical to this process. Therefore, we hypothesized that as we age, these tightly controlled physiological mechanisms become disrupted, possibly due to loss of transporter expression. We investigated this in vivo, using human skin samples from photoprotected and photoexposed sites of young and aged volunteers.We show a reduction in keratinocyte cell size with age and a downregulation of osmolyte transporters SMIT and TAUT with both chronic and acute UVR exposure.Single-cell live imaging demonstrated that aged keratinocytes lack efficient cell volume recovery mechanisms possessed by young keratinocytes following physiological stress. However, addition of exogenous taurine significantly rescued cell volume; this was corroborated by a reduction in TAUT mRNA and protein in aged, as compared to young, keratinocytes. Collectively, these novel data demonstrate that human epidermal keratinocytes possess osmolyte-mediated cell volume regulatory mechanisms, which may be compromised in aging. Therefore, this suggests that organic osmolytes-especially taurine-play a critical role in cutaneous age-related xerosis and highlights a fundamental mechanism, vital to our understanding of the pathophysiology of skin aging. K E Y W O R D Saging, cell volume, human skin, osmolytes

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“…Repeated facial expressions produce hyperfunctional facial rhytids, which progress with age, especially when associated with sun exposure, and in individuals who are heavy smokers or have poor diets (3)(4)(5)(6)(7). For some individuals, these lines are observed only with muscle contraction (dynamic rhytids), while for others, the lines are fully visible at rest (static rhytids).…”

Section: Introductionmentioning

confidence: 99%