The aim of this study was to analyze the factors associated with overweight and obesity in a sample of university students. This was a quantitative, cross-sectional analytical observational study conducted with undergraduate students at the main campus of the Federal University of Acre. The study included a total of 655 students, 58.3% being female and 41.7% male. The overweight was 48.9%, with higher rates among males (53.8%), those aged 30 years and older (76.6%), and those from families with incomes above three minimum wages (57.2%). Obesity was present in 18.2% of students, with higher rates among females (18.8%), those aged 30 years and older (34.2%), and 19.1% among those from families with incomes above three minimum wages. The age group of 30 years and older; non-utilization of the university restaurant; being female; and self-rated health as regular, poor, or very poor emerged as associated factors with overweight in university students in the adjusted final model. The same association pattern for obesity was observed, except for the variable of gender. The findings of this study point to a higher prevalence of overweight and obesity among older university students, those who reported unfavorable self-rated health, and those who reported not consuming meals offered at the UR.