Lifetime alcohol intake and risk of rectal cancer in western New York

Freudenheim, Jo L.; Graham, Saxon; Marshall, James R.; Haughey, Brenda P.; Wilkinson, Gregg S.

doi:10.1080/01635589009514050

Cited by 37 publications

(23 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11,15,16,19,25,41 Similarly, most epidemiologic studies report stronger associations between alcohol and CRC for men when compared with women. 15,19,39,41 Our data however, showed no interaction between alcohol consumption and sex, and an additional stratification of our analyses showed similar results for men and women. In addition to the large meta-analyses, [5][6][7]50 the Pooling Project 4 and the EPIC study, 8 we did not observe any evidence for sex-specificity.…”

Section: Discussionsupporting

confidence: 56%

“…The majority of individual casecontrol [10][11][12]39,[41][42][43][44][45] and cohort studies [14][15][16]18,25,40,[46][47][48][49] have shown rather inconsistent results, which in part can be explained by differing (methodological) aspects of these studies and lack of statistical power. To the best of our knowledge, our study is currently the largest single prospective study that has investigated associations between alcohol consumption and CRC.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites

Bongaerts

Brandt

Goldbohm³

et al. 2008

Intl Journal of Cancer

View full text Add to dashboard Cite

Within the Netherlands Cohort Study on diet and cancer, we investigated associations between total alcohol consumption, specific alcoholic beverage consumption and risk of colorectal cancer (CRC) according to anatomical subsite. Hazard Ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models. Analyses were performed on 2,323 CRC cases, available after 13.3 years of follow-up. Compared to abstaining, alcohol consumption of 30.0 g/day (3 alcoholic drinks) was positively associated with the risk of CRC (HR: 1.32, 95% CI: 1.06-1.65). Analyses restricted to subjects who reported to have consumed equal amounts of alcohol 5 years before baseline compared to baseline, showed elevated risk estimates for consumers of 30.0 g of total alcohol per day as well (HR: 1.53, 95% CI: 1.16-2.01). Suggestive of a subsite-specific effect, cancer risk seemed to increase from proximal colon through rectum; HR: 1.29, 95% CI: 0.85-1.96 for proximal colon cancer, HR: 1.41, 95% CI: 0.94-2.11 for distal colon cancer, HR: 2.07, 95% CI: 1.03-4.18 for rectosigmoid cancer and HR: 1.69, 95% CI: 1.08-2.64 for rectal cancer. No associations were observed between consumption of alcoholic beverages and CRC risk when compared with the nondrinkers of the specific beverage and after adjustment for total alcohol intake. No evidence was found for sex-specific effects of alcohol and alcoholic beverages. In conclusion, our data showed a positive association between alcohol consumption and risk of CRC, which seemed to be mainly explained by the alcoholic content of alcoholic beverages, rather than other constituents. Also, cancer risk may vary according to anatomical subsite.

show abstract

Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites

Bongaerts

Brandt

Goldbohm³

et al. 2008

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…This is in line with the findings of several earlier investigations (Sundby, 1967;Hakulinen et al, 1974;Nicholls et al, 1974;Monson & Lyon, 1975;Graham et al, 1978;Hirayama, 1979;Jensen, 1979Jensen, , 1980Robinette et al, 1979;Klatsky et al, 1981Klatsky et al, , 1988Schmidt & Popham, 1981;Manousos et al, 1983;Kono et al, 1986;Potter & McMichael, 1986;Tuyns, 1988). Our study thus does not support the alleged association between alcoholic beverages (Wynder & Shigematsu, 1967;Pickle et al, 1984;Hirayama, 1989;Carstensen et al, 1990;Freudenheim et al, 1990;Longnecker, 1990) including beer (Wynder & Shigematsu, 1967;Miller et al, 1983;Pollack et al, 1984;Kabat et al, 1986;Kune et al, 1987;Carstensen et al, 1990;Freudenheim et al, 1990) and the development of rectal cancer in particular. Owing to the size of the present study the relative risk estimate of 1.0 is quite precise, and it is unlikely that these heavy alcoholics have a more than 30% increased risk.…”

Section: Discussioncontrasting

confidence: 50%

Cancer morbidity in alcohol abusers

Tønnesen¹,

Møller²,

Andersen³

et al. 1994

Br J Cancer

View full text Add to dashboard Cite

Summary Data on the association between alcohol abuse and cancer morbidity are scarce in large cohorts of non-hospitalised alcoholic men and women. Of 18,368 alcohol abusers who entered an outpatient clinic in Copenhagen during 18,307 were followed and their cancer incidence was compared with that of the total Danish population. On average the 15,214 men were observed for 12.9 years and the 3,093 women for 9.4 years. The overall morbidity of cancer was increased significantly. Of the men, 1,441 developed cancer [relative risk (RR) = 1.6; 95% confidence interval (CI) = 1.5-1.7], while 182 women did (RR = 1.5; 95% CI 1.3-1.8).Significantly increased incidences were found of cancer in the tongue, mouth, pharynx, oesophagus, liver, larynx, lung and pleura and secondary cancer. The women had significantly increased risk of cervical cancer (RR = 2.0; 95% CI 1.2-3.0). The men developed prostatic cancer significantly more frequently than expected (RR = 1.4; 95% CI 1.2-1.8). The risk of melanomas (RR = 0.5; 95% CI 0.2-0.8) was significantly lower than expected. The relative risks of cancer of the stomach, pancreas, kidney and endocrine system were only slightly increased. The study group did not develop more colonic (RR = 1.0; 95% CI 0.8-1.3) or rectal cancer (RR = 1.0; CI 0.7-1.3) than expected. The risk of breast cancer in women was slightly increased (RR = 1.3; 95% CI 0.9-1.7), but not statistically significant. Thus, the associations between alcohol and cancer of the upper digestive and respiratory tract and the liver are confirmed. In addition, this study indicates an increased occurrence of cancer of the prostate gland, pleura and uterine cervix in alcohol abusers.

show abstract

“…Among these, five studies [41,67,68,76,82] were totally negative, and showed no evi dence of association with any of the large bowel subsites, sex strata or type of alcohol beverages. Three others showed overall signif icant direct associations, one [71] between beer and rectal cancer (RR = 2.7 for the high est consumption level), one [74] between total alcohol consumption and again rectal cancer only, but with RR estimates below 2 in both sexes. Both studies were conducted in North America.…”

Section: Case-control Studiesmentioning

confidence: 99%

“…Some North American studies [71,74,75,83] and an Australian one [72] found elevated risks, but were not confirmed by oth er studies from Europe, including one from Belgium [73] where beer is the commonest alcoholic beverage. This may suggest that dif ferent correlates of beer drinking in various populations may account for some of the ele vated risks, rather than supporting a general carcinogenic effect of beer itself on the rectal epithelium.…”

Section: Case-control Studiesmentioning

confidence: 99%

Alcohol and the Risk of Cancers of the Stomach and Colon-Rectum

Franceschi¹,

Vecchia

1994

Dig Dis

View full text Add to dashboard Cite

Alcohol drinking is strongly related to cancer of the upper digestive tract, but the pattern of risk with alcohol drinking is clearly different for cancer of the stomach and colon-rectum. All twelve cohort studies and three-quarters of 40 case-control investigations on the topic weigh against the possibility of a substantial effect of alcohol consumption on the risk of stomach cancer. Evidence is still insufficient to establish whether cancer of the cardiac region of the stomach is related to alcohol intake to any different extent than the rest of the stomach. With reference to colorectal cancer, different types of epidemiological studies are consistent in suggesting some direct relations with alcohol drinking. The association, however, is moderate, and an elevated risk of a factor 2 – or even of a factor 1.5 – for both cancers of the colon and rectum can now be excluded even for the highest levels of alcohol consumption.

show abstract

Lifetime alcohol intake and risk of rectal cancer in western New York

Cited by 37 publications

References 40 publications

Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites

Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites

Cancer morbidity in alcohol abusers

Alcohol and the Risk of Cancers of the Stomach and Colon-Rectum

Contact Info

Product

Resources

About