Lifetime Modulation of the Pain System via Neuroimmune and Neuroendocrine Interactions

Zouikr, Ihssane; Karshikoff, Bianka

doi:10.3389/fimmu.2017.00276

Cited by 34 publications

(31 citation statements)

References 278 publications

(365 reference statements)

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“…67 These activated mast cells may then go on to establish a self-sustaining positive feedback of neuroinflammation and autoimmunity, 68e70 with further complex interactions with other endocrine systems. 71,72 Our approach is independent of any assumptions about the ultimate underlying cause of ME/CFS. Observed patterns of immune dysregulation in the study cohort are sufficient for us to project concomitant differences in the HPA and HPG axes informed by known regulatory relationships between these systems.…”

Section: Discussionmentioning

confidence: 99%

Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome

Morris

Cooney

Sedghamiz

et al. 2019

Clinical Therapeutics

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Purpose: The complex and varied presentation of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has made it difficult to diagnose, study, and treat. Its symptoms and likely etiology involve multiple components of endocrine and immune regulation, including the hypothalamic-pituitaryadrenal axis, the hypothalamic-pituitary-gonadal axis, and their interactive oversight of immune function. We propose that the persistence of ME/CFS may involve changes in the regulatory interactions across these physiological axes. We also propose that the robustness of this new pathogenic equilibrium may at least in part explain the limited success of conventional single-target therapies. Methods: A comprehensive model was constructed of female endocrineeimmune signaling consisting of 28 markers linked by 214 documented regulatory interactions. This detailed model was then constrained to adhere to experimental measurements in a subset of 17 candidate immune markers measured in peripheral blood of patients with ME/ CFS and healthy control subjects before, during, and after a maximal exercise challenge. A set of 26 competing numerical models satisfied these data to within 5% error. Findings: Mechanistically informed predictions of endocrine and immune markers that were either unmeasured or exhibited high subject-to-subject variability pointed to possible context-specific overexpression in ME/CFS at rest of corticotropinreleasing hormone, chemokine (C-X-C motif) ligand 8, estrogen, follicle-stimulating hormone (FSH), gonadotropin-releasing hormone 1, interleukin (IL)-23, and luteinizing hormone, and underexpression of adrenocorticotropic hormone, cortisol, interferon-g, IL-10, IL-17, and IL-1a. Simulations of rintatolimod and rituximab treatment predicted a shift in the repertoire of available endocrineeimmune regulatory regimens. Rintatolimod was predicted to make available substantial remission in a significant subset of subjects, in particular those with low levels of IL-1a, IL-17, and cortisol; intermediate levels of progesterone and FSH; and high estrogen levels. Rituximab treatment was predicted to support partial remission in a smaller subset of patients with ME/ CFS, specifically those with low norepinephrine, IL-1a, chemokine (C-X-C motif) ligand 8, and cortisol

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Section: Discussionmentioning

confidence: 99%

Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome

Morris

Cooney

Sedghamiz

et al. 2019

Clinical Therapeutics

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“…Moderne Schmerztheorien verstehen unter Schmerzmodulation Veränderungen der Schmerzwahrnehmung (Verringerung, Verstärkung), die immuno-neuro-endokrin vermittelt werden und in Abhängigkeit von aktuellen und vergangenen Umwelteinflüssen stehen [89].…”

Section: Schmerzmodulationunclassified

“…Aus Tierversuchen ist bekannt, dass die bidirektionale Interaktion zwischen Immun-und Nervensystem ausschlaggebend für die Schmerzmodulation ist [89]. Wie erläutert, können widrige oder traumatische Lebensereignisse wie Gewalt oder Missbrauch bereits während Schwangerschaft, Geburt oder früher Kindheit die Stressregulation aus dem Gleichgewicht bringen.…”

Section: Schmerzmodulationunclassified

“…Bei der Behandlung chronischer Schmerzen müssenim Kontext aktueller als auch frühkindlicher Stresserfahrungenpsychoneuroimmunologische Wechselwirkungen miteinbezogen werden [89]. Die systematische Reduktion von Entzündung gilt als wesentliches Kriterium der Schmerzverbesserung und sollte sowohl topdown als auch bottom-up realisiert werden [58].…”

Section: Therapie Chronischer Schmerzpatientenunclassified

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Körperlich-seelische Berührungen im Fokus der Psychoneuroimmunologie

Ott¹,

Singer²,

Brisch³

et al. 2020

Hebamme

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Die Psychoneuroimmunologie zeigt, dass Berührungs- und Bindungserfahrungen pränatal und in der frühen Kindheit unser Stresserleben und ‑verhalten bis ins hohe Alter „programmieren“. Infolgedessen leiden körperlich und seelisch traumatisierte Kinder später öfters unter entzündungsassoziierten Krankheiten und chronischen Schmerzen. Die Forschung belegt weiter, dass Berührungstraumen und der damit verbundene Schmerz überwunden werden können.

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“…2 Chronic pain is a debilitating and challenging condition for both clinicians and researchers. 4 Despite intense research, it is still not clear why some individuals develop chronic pain while others do not; nor is it clear how to heal this disease. 4 TN and PIFP are considered to be two of the most confusing and difficult to treat facial pain conditions.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Facial Pain with I Ching Balance Acupuncture

Kotlyar

2017

Medical Acupuncture

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Background: Trigeminal neuralgia (TN) is the most common cranial neuralgia in adults, with a slightly higher incidence in women than in men. This chronic pain condition affects the trigeminal nerve, also known as the 5th cranial nerve. It is one of the most deeply distributed nerves in the head. Antiseizure drugs are the main biomedical treatment of TN. However, TN is not the only source of facial pain. Background persistent idiopathic facial pain (PIFP) is also a chronic disorder, recurring daily for more than 2 hours per day over more than 3 months. PIFP occurs in the absence of a neurologic deficit. The underlying pathophysiologies of TN and PIFP are still unknown, and treatment options have not been sufficiently evaluated. Nevertheless, neuropathic mechanisms could be relevant in both TN and PIFP. Cases: A 65-year-old Caucasian female with left facial pain was diagnosed by a neurologist with TN *2.5 years prior to seeking acupuncture treatment. A 42-year-old Caucasian female with left and right facial pain was diagnosed by a neurologist with PIFP *3 years prior to commencing acupuncture treatment. The cause of facial pain was treated with 60-minute sessions of I Ching Balance Acupuncture (ICBA) twice per week. Prior to each session, the effect of the previous session was recorded carefully in the patients' files. Results: A complete dissipation of pain was achieved after 29 and 60 ICBA sessions in the TN and the PIFP patient, respectively. Conclusions: The present article is the one of the first to demonstrate the efficacy of ICBA treatment for refractory facial pain. As the present article shows, ICBA treatment affects facial pain of different types successfully. However, additional larger-scale studies are necessary to validate the efficacy of ICBA in TN and PIFP treatment.

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Lifetime Modulation of the Pain System via Neuroimmune and Neuroendocrine Interactions

Cited by 34 publications

References 278 publications

Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome

Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome

Körperlich-seelische Berührungen im Fokus der Psychoneuroimmunologie

Treatment of Facial Pain with I Ching Balance Acupuncture

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