Ligand Exchange/Scrambling Study of Gold(I)-Phosphine Complexes in the Solid Phase by DESI-MS Analysis

Recent Developments in Mass Spectrometry to Support Next-Generation Synthesis and Screening

“…These assays enabled inhibitor screening and kinetic determination at analysis times of approximately 3 samples/s, while providing excellent correlation with optical methods . In an overview by Iqbal and co-workers, DESI has also been used to characterize pharma-relevant mechanochemical synthetic reactions by measuring ligand exchange/scrambling reaction products in the solid phase . Another recent technological development features the use of IR-MALDESI for HTS applications.…”

“…37 In an overview by Iqbal and co-workers, DESI has also been used to characterize pharma-relevant mechanochemical synthetic reactions by measuring ligand exchange/scrambling reaction products in the solid phase. 38 Another recent technological development features the use of IR-MALDESI for HTS applications. IR-MALDESI was pioneered in the laboratories of David Muddiman at NC State and utilizes a hybrid MS source that combines benefits of both ESI and MALDI.…”

Recent Approaches for Chemical Speciation and Analysis by Electrospray Ionization (ESI) Mass Spectrometry

“…ESI-MS (Jaklová Dytrtová et al, 2016) Al ESI-TOF (Feng et al, 2015;Raymond et al, 2018) As ESI-MS-MS (Liu et al, 2018) Au DESI-MS (Kazimi et al, 2019) Be ESI-TOF (Raymond et al, 2018) Ca ESI-FT-ICR (Mapolelo et al, 2009) Co ESI-MS-MS (Tsednee et al, 2016) Cu ESI-MS (Jaklová Dytrtová et al, 2016), ESI-MS-MS (Tsednee et al, 2016), ESI-FT-ICR (Waska et al, 2016) Er ESI-TOF (Indelicato et al, 2014) Fe ESI-MS-MS, (Tsednee et al, 2016), ESI-FT-MS (Waska et al, 2016, Mapolelo et al, 2009 K ESI-FT-ICR (Mapolelo et al, 2009) Mg ESI-FT-ICR (Mapolelo et al, 2009) Na ESI-FT-ICR (Mapolelo et al, 2009) Ni ESI-MS-MS (Tsednee et al, 2016) Pd ESI-TOF (Jo et al, 2019) Ru DESI-MS (Perry et al, 2011) Se ESI-MS-MS (Tie et al, 2015) U ESI-TOF (Davis and Clowers, 2018) V ESI-TOF (Wen et al, 2019), ESI-TOF (time resolved) (Cao et al, 2016) W ESI-TOF (time resolved) (Cao et al, 2016) Yb ESI-TOF (Indelicato et al, 2013) Zn ESI-MS-MS (Tsednee et al, 2016) to predominant bis-chelated beryllium complexes known to be formed with the monoanionic 1,3-diketonate ligands. ESI-MS measurements, along with differential functional theory calculations, have been exploited (Kumar et al, 2016) to understand the speciation of various uranyl species with α-hydroxyisobutyric acid.…”

“…Some authors studied Ru +2 complexes (Perry et al, 2011) evidencing that, in the short time scales of DESI, it is possible to detect trace levels (pmol) of short-lived intermediates characterized by lifetimes in the order of milliseconds. In a more recent work, Kazimi et al (2019) exploited DESI to investigate, in the solid phase, a gold-based drug actually in clinical trials for its anticancer properties: auranofin. Auranofin was reacted with thiol-containing amino acids to evaluate the ligand exchange/scrambling reactions.…”