Ligand-free, PdCl2(PPh3)2 catalyzed, microwave-assisted Suzuki coupling of 1-chloro-3-phenylisoquinoline in the synthesis of diversified 1,3-disubstituted isoquinolines

Abstract

An efficient ligand-free, microwave-assisted, Pd-catalyzed, Suzuki coupling of 1-chloro-3-phenylisoquinoline and boronic acids, in the presence of sodium carbonate base and 1,4-dioxane solvent, is reported for the synthesis of diversified 1,3-disubstituted isoquinolines.

Homogeneous and Recyclable Palladium Catalysts: Application in Suzuki–Miyaura Cross-Coupling Reactions

“…After consideration of the reaction time, solvent employed, and temperature, we selected L1 , THF, and room temperature as perfectly cromulent reaction conditions. Our catalytic conditions are comparable in performance to other well-established Suzuki–Miyaura protocols employing PdCl 2 (dppf), although much lower loadings are possible employing current state-of-the-art methodology. − …”