1994
DOI: 10.1007/bf00239009
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Light and electron microscopic study of omental milky spots in New Zealand Black mice, with special reference to the extramedullary hematopoiesis

Abstract: Omental milky spots are especially large and numerous in New Zealand Black (NZB) mice, which are known to develop spontaneous autoimmune diseases. We investigated omental milky spots in NZB mice by light and electron microscopy. The milky spots were composed of abundant lymphocytes/plasma cells with macrophages, neutrophils, eosinophils, megakaryocytes, and various stromal cells. In addition, clustered neutrophils in various maturation stages with occasional mitotic figures were frequently present in the milky… Show more

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Cited by 9 publications
(16 citation statements)
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“…Omentum has been shown to produce several myeloid lineages, and it is able to respond to specific local demands (Cranshaw and Leak 1990;Hirai et al 1992;Takemori et al 1994). Milky spots are considered to be the source of peritoneal macrophages under normal conditions, and in regeneration after macrophage depletion (Biewenga et al 1995;Zhu et al 1997).…”
Section: Discussionmentioning
confidence: 98%
“…Omentum has been shown to produce several myeloid lineages, and it is able to respond to specific local demands (Cranshaw and Leak 1990;Hirai et al 1992;Takemori et al 1994). Milky spots are considered to be the source of peritoneal macrophages under normal conditions, and in regeneration after macrophage depletion (Biewenga et al 1995;Zhu et al 1997).…”
Section: Discussionmentioning
confidence: 98%
“…Besides cell rolling, adhesion, and transendothelial passage (diapedesis), an extravasating leukocyte has to move in the subendothelial matrix tissue prior to emigration through the mesothelium; finally, cell detachment from the connective tissue into the peritoneal cavity is required. In addition, white blood cell movement not from the mesentery but through the omentum (or milky spots) 35,36 seems to be the most common path taken by blood-borne granulocytes during peritonitis. For all these reasons we focused the present study on intravital microscopy of the mouse mesentery to identify the receptor mechanism(s) mediating the inhibitory effect of peptide Ac2-26 and, by analogy, full-length annexin 1 on the initial stages of the leukocyte extravasation process.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, some authors have divided MS in two categories: vascularized and non-vascularized MS. Vascularized MS are supplied with blood vessels and are found in the omental fat region. On the other hand, non-vascularized MS do not have blood supply and are located in the omental membrane (45). Whether these features that translate into functional differences remain to be investigated.…”
Section: Are Falcs Similar To Milky Spots (Ms) Of the Omentum?mentioning
confidence: 99%