Light and electron microscopic study on the possible protective effect of pomegranate peel extract on the pituitary- thyroid axis exposed to monosodium glutamate in adult male albino rats

Noya, Dalia A.; Soliman, Mahmoud E.; bashandi, manar Aly

doi:10.21608/ejh.2021.68994.1449

Cited by 1 publication

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“…Additionally, the long‐term consumption of PG juice by patients with hypertension lowered blood pressure and decreased the thickness of the common carotid arteries (Aviram et al, 2004). To our knowledge, only few studies have addressed the effects of PG on degenerative changes in the thyroid (Godarzi et al, 2016; Noya et al, 2022). Here, we evaluated the structural and functional changes in the thyroid gland of adult male rats caused by LC and the potential protective role of PG peel in ameliorating these changes.…”

Section: Introductionmentioning

confidence: 99%

Pomegranate (Punica granatum) peel alleviates lithium‐induced alterations in the thyroid gland of rats by modulating apoptosis and oxidative stress

El-Din

Fadel

Rashid

et al. 2022

The Anatomical Record

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Lithium carbonate (LC) is known to alter thyroid gland function. Pomegranate (PG) is a fruit with multiple antioxidant and antiapoptotic properties. Here, we studied the effect of PG on LC-induced morphological and functional alterations in the thyroid glands of rats. Rats were divided into four groups: control, lithium, lithium-PG, and PG. After 8 weeks, the rats were sacrificed, the levels of thyroid hormones and oxidative stress markers were estimated, and thyroid tissues were subjected to histological, immunohistochemical, and ultrastructural evaluations. Compared to the control group, the lithium group showed significant changes in thyroid hormone levels, greater expression of the oxidant marker malondialdehyde, and lower expression of the antioxidant marker superoxide dismutase (SOD). Most of these changes improved upon PG treatment. Histological evaluation of the thyroid in the lithium group showed disorganization and follicle involution. Additionally, the periodic acid Schiff staining intensity and SOD immunoreactivity declined significantly, whereas the collagen fiber content and Bax immunoreactivity increased. The follicular ultrastructure showed marked distortion. These changes were mitigated upon PG treatment. In conclusion, PG alleviated the morphological and functional changes in the thyroid glands induced by LC by modulating apoptosis and oxidative stress.

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Section: Introductionmentioning

confidence: 99%