Light-at-night, cancer and aging

Bartsch, Christian

doi:10.18632/aging.100126

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…7 Global co-distribution of light at night and cancers of breast, prostate and some others was demonstrated in humans. [8][9][10] Constant illumination probably exerts its detrimental effects on health, tumorigenesis as well as survival via disturbances of the female reproductive cycle. 11 The mechanisms involved can be assumed to include the pineal hormone the effect of the constant illumination on the development of spontaneous tumors in female 129/Sv mice was investigated.…”

Section: Introductionmentioning

confidence: 99%

Exposure to light at night accelerates aging and spontaneous uterine carcinogenesis in female 129/Sv mice

et al. 2013

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The effect of the constant illumination on the development of spontaneous tumors in female 129/Sv mice was investigated. Forty-six female 129/Sv mice starting from the age of 2 mo were kept under standard light/dark regimen [12 h light (70 lx):12 hr dark; LD, control group], and 46 of 129/Sv mice were kept under constant illumination (24 h a day, 2,500 lx, LL) from the age of 5 mo until to natural death. The exposure to the LL regimen significantly accelerated body weight gain, increased body temperature as well as acceleration of age-related disturbances in estrous function, followed by significant acceleration of the development of the spontaneous uterine tumors in female 129/Sv mice. Total tumor incidence as well as a total number of total or malignant tumors was similar in LL and LD group (p > 0.05). The mice from the LL groups survived less than those from the LD group (χ ( 2) = 8.5; p = 0.00351, log-rank test). According to the estimated parameters of the Cox's regression model, constant light regimen increased the relative risk of death in female mice compared with the control (LD) group (p = 0.0041). The data demonstrate in the first time that the exposure to constant illumination was followed by the acceleration of aging and spontaneous uterine tumorigenesis in female 129/Sv mice.

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Section: Introductionmentioning

confidence: 99%

Exposure to light at night accelerates aging and spontaneous uterine carcinogenesis in female 129/Sv mice

et al. 2013

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“…Increasing evidence suggests that the presence of constant light can disrupt many aspects of circadian rhythm and have negative effects on physiology. In vertebrates, including humans, such physiological effects of constant exposure to light include disruptions to juvenile growth ( Bruning, Hölker & Wolter, 2011 ), accelerated aging ( Vinogradova et al, 2009 ; Bartsch, 2010 ), increased depression and anxiety ( Ma et al, 2007 ; Fonken et al, 2009 ), an increased risk of cancer ( Blask et al, 2003 ; Anisimov et al, 2004 ; Anisimov, 2006 ; Haim & Zubidat, 2015 ) and generally a negative impact on immune function ( Maestroni, Conti & Pierpaoli, 1986 ; Moore & Siopes, 2000 ; Oishi et al, 2006 ). The absence of a circadian cue is likely to be a strong driver behind these effects; however, similar effects are evident in response to an extension in the number of hours of light exposure ( Megdal et al, 2005 ; Blask, 2009 ; Stevens, 2009 ; Dickerman & Liu, 2012 ) or exposure to dim light during periods of natural darkness ( Kloog et al, 2010 ; Spivey, 2010 ; Bedrosian et al, 2011 ; Aubrecht, Weil & Nelson, 2014 ; Borniger et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Constant illumination reduces circulating melatonin and impairs immune function in the cricketTeleogryllus commodus

Durrant

Michaelides

Rupasinghe

et al. 2015

PeerJ

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Exposure to constant light has a range of negative effects on behaviour and physiology, including reduced immune function in both vertebrates and invertebrates. It is proposed that the associated suppression of melatonin (a ubiquitous hormone and powerful antioxidant) in response to the presence of light at night could be an underlying mechanistic link driving the changes to immune function. Here, we investigated the relationship between constant illumination, melatonin and immune function, using a model invertebrate species, the Australian black field cricket, Teleogryllus commodus. Crickets were reared under either a 12 h light: 12 h dark regimen or a constant 24 h light regimen. Circulating melatonin concentration and immune function (haemocyte concentration, lytic activity and phenoloxidase (PO) activity) were assessed in individual adult crickets through the analysis of haemolymph. Constant illumination reduced melatonin and had a negative impact on haemocyte concentrations and lytic activity, but its effect on PO activity was less apparent. Our data provide the first evidence, to our knowledge, of a link between exposure to constant illumination and variation in haemocyte concentration in an invertebrate model, while also highlighting the potential complexity of the immune response following exposure to constant illumination. This study provides insight into the possible negative effect of artificial night-time lighting on the physiology of invertebrates, but whether lower and potentially more ecologically relevant levels of light at night produce comparable results, as has been reported in several vertebrate taxa, remains to be tested.

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Sex and estrous cycle dependent changes in locomotor activity, anxiety and memory performance in aged mice after exposure of light at night

Datta

Samanta

Tiwary

et al. 2019

Behavioural Brain Research

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Light-at-night, cancer and aging

Cited by 4 publications

References 11 publications

Exposure to light at night accelerates aging and spontaneous uterine carcinogenesis in female 129/Sv mice

Exposure to light at night accelerates aging and spontaneous uterine carcinogenesis in female 129/Sv mice

Constant illumination reduces circulating melatonin and impairs immune function in the cricketTeleogryllus commodus

Sex and estrous cycle dependent changes in locomotor activity, anxiety and memory performance in aged mice after exposure of light at night

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