Light Chain Distribution in Immune Deposits on Glomeruli of Kidneys in Human Renal Disease*

Complement in Human Disease

“…These differences in complement data in patients with chronic glomerulonephritis are probably the result of analysis at different stages of the disease process, and perhaps also of differences in the disease being studied. Many patients with chronic glomerulonephritis have gamma globulin (76, 104-107) and C'3 (� lC) (76,104,105,107) on the basement membrane. In nearly one half of the patients with chronic glomerulonephritis, the de posits lie in a linear fashion along the basement membrane; other cases have focal lumpy deposits, as seen in SLE and acute post-streptococcal glomerulonephritis (lOS).…”

“…Goodpasture's syndrome: Whole serum complement levels have been reported in only one case of Goodpasture's syndrome, in which it was nor mal (107). Complement, however, may be involved in the renal pathology because, in all instances, yG-globulin and �lC (C'3) have been found in a linear fashion along the basement membrane (104,105,107,109).…”

Cryoglobulins. II. The Biological and Chemical Properties of Cryoproteins in Acute Post-Streptococcal Glomerulonephritis

“…The demonstration of glomerular-localized streptococcal antigen in our previous work has been confirmed but the results of other studies have been absent, inconsistent or indicative of distribution in areas different from the deposits of IgG and ¡i u [McCluskey et al, 1960;Michael et al, 1966;Seegal et al, 1965], However, the plasma membrane of the streptococcus is the specific antigen and a series of events similar to ex perimental antigen-antibody complex disease is the pathogenic mecha nism [Lange et al, 1969], A similar pathogenic mechanism in experi mental glomerulonephritis induced by streptococcus in mice has been sug gested [Lindberg and Vosti, 1969]. IgG deposited on the glomeruli of patients with renal disease probably represents a specific antibody to an exogenous antigen rather than a non-specific sample of the circulating im munoglobulin pool [Herdman et al, 1967], Although we have been un able to demonstrate anti-streptococcal activity, the theory of a streptococ cal anti-streptococcal complex is not disproved since in SLE where the renal disease appears to be due to deposition of circulating complexes of nuclear antigen and its antibody [Krishnan and Kaplan. 1967], the pres ence of antinuclear antibody in the cryoproteins has been inconsistant, a discrepancy which may be due to antibody saturation with specific anti gens [Forsen and Barnett, 1968;Hanauer and Christian.…”