2022
DOI: 10.1101/2022.01.24.477628
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Light-controlled phosphorylation in the TrkA-Y785 site by photosensitive UAAs activates the MAPK/ERK signaling pathway

Abstract: TrkA is a membrane receptor that upon ligand binding, induces autophosphorylation of tyrosine residues in the intracellular domain, and this process includes sites in the kinase activation loop (Y670, Y674, Y675) and two direct sites involved in downstream signaling pathways (Y490, Y785). At present, researchers cannot fully elucidate the regulatory mechanism of TrkA phosphorylation because TrkA signaling is a highly dynamic process, and a strategy with high temporal and spatial resolution will be beneficial t… Show more

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