Light Dosimetry in Tissue: Application to Photoradiation Therapy

Doiron, Daniel R.; Svaasand, Lars O.; Profio, A. E.

doi:10.1007/978-1-4684-4406-3_8

Cited by 105 publications

(50 citation statements)

References 3 publications

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“…However, HPD and P-I1 are not ideal, being complex mixtures of several porphyrins and having a very low absorbance in the red region of the visible spectrum (Doiron et al, 1983). Attempts have been made to find better photosensitizers with the advantages of being single chemical substances and having a high absorbance in the red region of the spectrum (Ben-Hur and Rosenthal, 1985a;Berebaum et al, 1986;Rimington et al, 1987;Peng et al, 1987).…”

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confidence: 98%

Localization of fluorescent photofrin ii and aluminum phthalocyanine tetrasulfonate in transplanted human malignant tumor LOX and normal tissues of nude mice using highly light‐sensitive video intensification microscopy

Peng¹,

Nesland

Moan³

et al. 1990

Intl Journal of Cancer

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A comparative kinetic observation of the in vivo biolocalization of Photofrin II (P-II) and aluminum phthalocyanine tetrasulfonate (AIPCS4) in a transplanted human malignant tumor LOX and in normal tissues of nude mice has been made by means of highly light-sensitive video intensification microscopy at various intervals after i.p. administration. In the human tumor LOX, transplanted to athymic nude mice, fluorescence of P-II was observed on the membrane and in the cytoplasm of tumor cells, and in the stroma 4-48 hr post-injection. From 72 hr post-injection almost all fluorescing P-II had disappeared from the membrane of the tumor cells while strong fluorescence was still found in the stroma. AIPCS4 fluorescence was seen mainly in tumorous stroma with none detected in the tumor cells. Almost no fluorescence was found in the tumorous stroma 24 hr after injection. In most normal tissues observed, P-II was eliminated at a much slower rate than AIPCS4, but the in vivo biolocalization of the 2 drugs was similar. They were observed primarily where collagenous proteins are normally found, i.e. basal lamina, collagenous connective tissue, and in keratinized epithelium, renal epithelium, mononuclear phagocyte system and on the membrane of muscular cells. In addition, AIPCS4 had a strong affinity for the bronchiogenic epithelium. In the skin, P-II was distributed in keratinized epithelium, hair, hair follicles and their accessory, collagenous connective tissue of dermis, whereas AIPCS4 was present only in hair and collagenous connective tissue of dermis. No fluorescence of P-II or of AIPCS4 was found in the skin epidermis, nor in the transitional epithelium of the bladder mucosa.

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confidence: 98%

Localization of fluorescent photofrin ii and aluminum phthalocyanine tetrasulfonate in transplanted human malignant tumor LOX and normal tissues of nude mice using highly light‐sensitive video intensification microscopy

Peng¹,

Nesland

Moan³

et al. 1990

Intl Journal of Cancer

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“…Therefore, superficial tumour illumination causes substantial liver necrosis (Pimstone et al, 1982). Moreover, the limited light penetration during superficial illumination makes it impossible to treat deep-seated or larger solid tumours (Doiron et al, 1983). These limitations could be overcome by implanting the light delivery fibres with diffusing cylinder tips directly into the tumour (interstitial therapy), thus applying the light selectively and with greater accessibility Holt et al, 1985;Arnfield et al, 1986;Gatenby et al, 1987;Marijnissen et al, 1992).…”

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Interstitial photodynamic therapy in a rat liver metastasis model

Hillegersberg

Marijnissen²,

Kort³

et al. 1992

Br J Cancer

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“…32 A second option, avoiding the need of short source-detector separations, is to measure absolute ͑instead of relative͒ fluence rate in the diffuse regime. 33 Data evaluation, by means of curve fitting, then yields eff and s Ј.…”

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In vivo optical characterization of human prostate tissue using near-infrared time-resolved spectroscopy

et al. 2007

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In vivo optical characterization of human prostate tissue using near-infrared timeresolved spectroscopy.Svensson, Tomas; Andersson-Engels, Stefan; Einarsdóttír, Margrét; Svanberg, Katarina General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.In vivo optical characterization of human prostate tissue using near-infrared time-resolved spectroscopy Tomas Svensson Stefan Andersson-EngelsLund University Department of Physics SE-221 00 Lund Sweden Margrét Einarsdóttír Katarina SvanbergLund University Hospital Department of Oncology SE-221 00 Lund Sweden Abstract. The development of photodynamic therapy into a modality for treatment of prostate cancer calls for reliable optical dosimetry. We employ, for the first time, interstitial time-resolved spectroscopy to determine in vivo optical properties of human prostate tissue. Nine patients are included in the study, and measurements are conducted prior to primary brachytherapy treatment of prostate cancer. Intrasubject variability is examined by measuring across three tissue volumes within each prostate. The time-resolved instrumentation proves its usefulness by producing good signal levels in all measurements. We are able to present consistent values on reduced scattering coefficients ͑ s Ј͒, absorption coefficients ͑ a ͒, and effective attenuation ͑ eff ͒ at the wavelengths 660, 786, and 916 nm. At 660 nm, s Ј is found to be 9±2 cm −1 , and a is 0.5± 0.

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Light Dosimetry in Tissue: Application to Photoradiation Therapy

Cited by 105 publications

References 3 publications

Localization of fluorescent photofrin ii and aluminum phthalocyanine tetrasulfonate in transplanted human malignant tumor LOX and normal tissues of nude mice using highly light‐sensitive video intensification microscopy

Localization of fluorescent photofrin ii and aluminum phthalocyanine tetrasulfonate in transplanted human malignant tumor LOX and normal tissues of nude mice using highly light‐sensitive video intensification microscopy

Interstitial photodynamic therapy in a rat liver metastasis model

In vivo optical characterization of human prostate tissue using near-infrared time-resolved spectroscopy

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