Light-Driven Self-Cascade Peroxidase-like Nanozymes without Exogenous H₂O₂

Abstract

The peroxidase (POD)-like nanozyme typically requires the addition of exogenous H 2 O 2 . To address the limitation, previous work mainly adopted a cascade strategy for H 2 O 2 production. Herein, we propose a new light-driven self-cascade strategy to construct POD-like nanozymes without exogenous H 2 O 2 . The model nanozyme resorcinol−formaldehyde resin-Fe 3+ (RF-Fe 3+ ) is synthesized with the hydroxyl-rich photocatalytic material RF as the carrier to in situ chelate metal oxides, which can simultaneously achieve the functions of in situ H 2 O 2 generation under irradiation and substrate oxidation via POD-like behavior. Notably, RF-Fe 3+ exhibits high affinity to H 2 O 2 , attributed to the excellent adsorption ability and hydroxyl-rich feature of RF. Furthermore, the dual photoelectrode-assisted photofuel cell was further constructed with a high-power density of 120 ± 5 μW cm −2 based on the RF-Fe 3+ photocathode. This work not only demonstrates the new selfcascade strategy of in situ generation of catalysis substrates but also provides an opportunity to extend the catalytical field.

Nanozymes Based on MXene Nanosheets Decorated with Pt Nanoparticles for Hyperthermal-Enhanced Cascade Catalytic Therapy of Tumors

“…The dispersion and loading of nanozymes onto MXene facilitate the delivery and catalytic reaction of nanozymes while combining photothermal properties to achieve synergistic photothermal-catalytic therapy. , POD-like nanozymes usually require the addition of exogenous H 2 O 2 . To overcome this limitation, a novel light-driven self-cascade strategy has been reported to construct POD-like nanozymes with no requirement for exogenous H 2 O 2 . Also considering the limited endogenous H 2 O 2 , implementing an in situ supply of H 2 O 2 within the TME will be of research significance.…”