Light-driven self-disinfecting textiles functionalized by PCN-224 and Ag nanoparticles

Nie, Xiaolin; Wu, Shuanglin; Liao, Shiqin; Chen, Juanfen; Huang, Fenglin; Li, Wei; Wang, Qingqing; Wei, Qufu

doi:10.1016/j.jhazmat.2021.125786

Cited by 45 publications

(14 citation statements)

References 64 publications

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“…Comparing the FTIR spectra of PM NFMs in Figure 4e, it can be found that the asymmetric and symmetric vibrations of CH2 at 2942 cm −1 and 2862 cm −1 were ascribed to PM−0 and the C=C bond stretching vibration appeared at 1552-1605 cm −1 , which was attributed to the presence of PCN−224 NPs [70]. The FTIR results indicating that the PCN−224 NPs were successfully introduced into PCL nanofibers [58,71]. The DSC results (Figure S6) demonstrate the possible coordination interaction between Zr metal nodes and PCL carbonyl groups under the introduction of PCN−224.…”

Section: Nanofiber Fabrication With Preformed Pcn−224mentioning

confidence: 90%

Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application

Zhang

Mao

et al. 2021

Polymers

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The rise and spread of antimicrobial resistance is creating an ever greater challenge in wound management. Nanofibrous membranes (NFMs) incorporated with antibiotics have been widely used to remedy bacterial wound infections owing to their versatile features. However, misuse of antibiotics has resulted in drug resistance, and it remains a significant challenge to achieve both high antibacterial efficiency and without causing bacterial resistance. Here, the ‘MOF-first’ strategy was adopted, the porphyrinic metal-organic frameworks nanoparticles (PCN−224 NPs) were pre-synthesized first, and then the composite antibacterial PCN−224 NPs @ poly (ε-caprolactone) (PM) NFMs were fabricated via a facile co-electrospinning technology. This strategy allows large amounts of effective MOFs to be integrated into nanofibers to effectively eliminate bacteria without bacterial resistance and to realize a relatively fast production rate. Upon visible light (630 nm) irradiation for 30 min, the PM−25 NFMs have the best 1O2 generation performance, triggering remarkable photodynamic antibacterial effects against both S. aureus, MRSA, and E. coli bacteria with survival rates of 0.13%, 1.91%, and 2.06% respectively. Considering the photodynamic antibacterial performance of the composite nanofibrous membranes functionalized by porphyrinic MOFs, this simple approach may provide a feasible way to use MOF materials and biological materials to construct wound dressing with the versatility to serve as an antibacterial strategy in order to prevent bacterial resistance.

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Section: Nanofiber Fabrication With Preformed Pcn−224mentioning

confidence: 90%

Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application

Zhang

Mao

et al. 2021

Polymers

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“…With greater illumination time, the absorbance of the characteristic absorption peaks of polydopamine at 480 nm and 700 nm increased continuously. [25] Similarly, the color of the solution in the illustration became darker, exhibiting the black of polydopamine at 60 minutes. This showed that ROS were able to oxidatively polymerize dopamine and that the degree of dopamine polymerization could be regulated by adjusting the illumination time.…”

Section: Synthesis and Characterization Of Ha-da And Pcn@bpmentioning

confidence: 95%

“…In addition, previous literature suggests that the natural oxidation of DA can be greatly inhibited at this pH without the oxidative polymerization of ROS being affected. [25] Hence, as shown in Figure 3b, the HA-DA/Fe 3+ /PCN@BP hydrogel was irradiated with a 660 nm laser to excite PCN@BP to generate active oxygen that would then oxidize DA to form chemical crosslinks, finally yielding a physical/chemical double-crosslinked hydrogel.…”

Section: Synthesis Of Ha-da/fe 3+ /Pcn@bp Hydrogel With Tunable Mechanical Properties Fast Self-healing and Rapid Shape Adaptabilitymentioning

confidence: 99%

Dual‐Light‐Triggered In Situ Structure and Function Regulation of Injectable Hydrogels for High‐Efficient Anti‐Infective Wound Therapy

Zhang

et al. 2021

Adv Healthcare Materials

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Most injectable hydrogels used in biomedical engineering have unsatisfactory and untunable mechanical properties, making it difficult to match them with the mechanical strengths of different tissues and organs, which can cause a series of adverse consequences such as immune rejection and soft tissue contusion. In this contribution, dopamine-modified hyaluronic acid (HA-DA) is developed as the backbone for an injectable hydrogel using a catechol-Fe 3+ coordination crosslinking strategy. Due to dynamic physical crosslinking, the hydrogel can be easily injected through a single syringe. Into the hydrogel, black phosphorous nanosheets loaded with a Zr-based porphyrinic metal−organic framework (PCN@BP) are introduced that could generate reactive oxygen species (ROS) under 660 nm laser irradiation, this promotes the oxidative coupling of dopamine in the presence of the ROS, introducing in situ chemical crosslinking into the hydrogel. A physical/chemical double-crosslinked hydrogel is obtained, effectively improving the hydrogel's mechanical properties, which are tuned in situ by adjusting the irradiation time to match the mechanical modulus of different biological tissues. Combining the excellent photothermal properties and photodynamic performance of the PCN@BP nanosheets yields effective sterilization under mild conditions (below 50 °C, low ROS production). The results show that this hydrogel is an excellent multifunctional wound dressing.

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“…Generally, antibacterial gauze can be obtained by introducing various classes of antibacterial agents, such as antibiotics, metal ions and nanoparticles, − quaternary ammonium, − and antibacterial polymers, onto the fabric surface through different physical or chemical techniques. Although these functional fabrics exhibited good activities in killing bacteria, several critical challenges remain that restrict their large-scale practical application as wound dressings.…”

Section: Introductionmentioning

confidence: 99%

Facile and Robust Antibacterial Functionalization of Medical Cotton Gauze with Gallic Acids to Accelerate Wound Healing

Lang

Chen

Xiang

et al. 2021

Ind. Eng. Chem. Res.

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The clinical treatment of wounds with medical cotton gauze often encounters inflammation and excessive immune response triggered by bacterial infections, which can significantly prolong the wound healing process. It is, therefore, of great significance to develop functional gauzes with broad-spectrum antibacterial and anti-inflammatory activities. Herein, we report a convenient, robust, and practical strategy to functionalize medical cotton gauze by covalently immobilizing plant-derived gallic acids. The obtained GA@Gauze exhibits not only excellent biosafety and washing durability but also broad-spectrum bacterial antiadhesion and bactericidal activities. More importantly, in vivo experiments confirm that GA@Gauze can effectively reduce the bacterial invasion and regulate inflammatory responses, resulting in faster production of collagen fibers and accelerated wound healing. Therefore, this simple and powerful route has great potential for fabricating the next-generation functional gauzes for clinical treatment of wounds.

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Light-driven self-disinfecting textiles functionalized by PCN-224 and Ag nanoparticles

Cited by 45 publications

References 64 publications

Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application

Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application

Dual‐Light‐Triggered In Situ Structure and Function Regulation of Injectable Hydrogels for High‐Efficient Anti‐Infective Wound Therapy

Facile and Robust Antibacterial Functionalization of Medical Cotton Gauze with Gallic Acids to Accelerate Wound Healing

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