Light-emitting Diode Phototherapy at 630.+-.3 nm Increases Local Levels of Skin-homing T-cells in Human Subjects

Takezaki, Shinichiro; Omi, Tokuya; Satō, Shigeru; Kawana, Seiji

doi:10.1272/jnms.73.75

Cited by 20 publications

(11 citation statements)

References 20 publications

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“…Takezaki et al [21] reported that 630 VIS LED irradiation on a human leg surface resulted in the migration of T cells to the skin and the prevailing cytokine of cultured skin-homing T cells was shown to be IL-4 using transmission electron microscopy and PCR. Though the wavelength was not exactly the same as ours in this study, both wavelengths belong to near-infrared VIS.…”

Section: Discussionmentioning

confidence: 99%

“…The exposure to light of immune-competent cells leads to changes in their functional condition and, consequently, to the stimulation of the immune system, manifesting itself in the increased defense capacity of an organism [17]. VIS and infrared light regulate human humoral immunity [18], manage allergic rhinitis [19], increase antitumor immunity [20] and skin-homing T cells [21], and stimulate DNA synthesis in human peripheral blood lymphocytes [22]. …”

Section: Introductionmentioning

confidence: 99%

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Effect of 710-nm Visible Light Irradiation on Neuroprotection and Immune Function after Stroke

Choi

Lim

Lee

et al. 2012

Neuroimmunomodulation

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Objective: The phototherapeutic effects of low level infrared laser irradiation (808 nm) on brain neuronal cell protection after stroke have been presented recently. We previously reported that 710-nm wavelength visible light (VIS) increases total lymphocyte counts in vivo, especially CD4⁺ T lymphocytes. In this study, we investigated the effects of 710-nm VIS irradiation on neuronal protection and recovery correlating with cellular immunity in stroke rats. Methods: Rats were subjected to 90-min middle cerebral artery occlusion (MCAO) followed by reperfusion and were divided into two groups: irradiation and no irradiation. The irradiation group had been exposed to 710-nm VIS for 3 weeks after MCAO establishment or sham operation. The helper T cell (CD4⁺) count in the whole blood and infarct volume were measured. Messenger RNA expression levels of IL-4 and IL-10 in peripheral blood mononuclear cells were measured, a histologic study including microglia activation and regulatory T (Treg) cell markers, neurological severity scoring and a parallel bar walking test were all performed. Results: CD4⁺ cell count was reduced after MCAO but was significantly increased by 710-nm VIS irradiation. The infarct sizes were decreased in the MCAO + irradiation group compared with the MCAO control group. IL-10 mRNA expression and the immunoreactivity of Treg cells were increased in the MCAO + irradiation group compared with the MCAO control group. Increased microglia activation after MCAO was reduced by 710-nm VIS irradiation. The irradiation group also showed improved neurological severity score levels and step fault scores after MCAO. Conclusions: Our data suggest that 710-nm VIS irradiation may activate cellular immunity, reduce brain infarction and ultimately induce functional recovery in a stroke animal model.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of 710-nm Visible Light Irradiation on Neuroprotection and Immune Function after Stroke

Choi

Lim

Lee

et al. 2012

Neuroimmunomodulation

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“…Red light at 633 nm has been associated with treating the stress-related and hormonal factors of acne, in addition to its already proven effect on inflammation. 5,6 LED energy at 633 nm in humans in vivo has also been proved to recruit large numbers of Th1 and Th2 skin-homing T-cells into the irradiated skin, 13 which might help to replace the rogue Tcell population and break the vicious circle in psoriatic skin. The same combination LED therapy in a 4-week alternating regimen of 830 nm followed 24 to 72 h later by 633 nm has been convincingly and objectively shown to produce strong collagen and elastin synthesis in a large-population controlled study of skin rejuvenation.…”

Section: Ablonmentioning

confidence: 99%

Combination 830-nm and 633-nm Light-Emitting Diode Phototherapy Shows Promise in the Treatment of Recalcitrant Psoriasis: Preliminary Findings

Ablon

2010

Photomedicine and Laser Surgery

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“…Estudos têm demonstrado que a radiação tecidual com fontes de luz com baixa intensidade, como o diodo emissor de luz (LED) de baixa intensidade, na faixa do vermelho ao infravermelho próximo, pode ser uma estratégia efetiva para modular a dor e favorecer o processo de cicatrização tecidual (Lagan et al 2000, Lucas et al 2003, Takezaki et al 2006. Os benefícios do LED e do laser de baixa intensidade têm sido observados em condições tais como osteoartrite, radiculopatias, tendinites e, principalmente, no tratamento de feridas cutâneas em animais (Kana et al 1981, Soares et al 1989, Matera et al 2003) e em humanos (Corrêa et al 2003, Siqueira et al 2004.…”

Section: Introductionunclassified

Dispositivo fotobiomodulador para prevenção e tratamento de hiperqueratose de teto em vacas leiteiras

Lage

Araújo²,

Teixeira

et al. 2014

Pesq. Vet. Bras.

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Pesq. Vet. Bras. 34(6):515-522, junho 2014 515 RESUMO.-As mastites estão entre as principais causas de prejuízo para produtores de leite. Em casos graves de hiperqueratose, o canal do teto pode se tornar uma barreira mais fácil para que as bactérias penetrem na glândula mamária. Os objetivos deste estudo foram avaliar um dispositivo fotobiomodulador de LED para tratamento e prevenção de hiperqueratose de teto e prevenção da mastite subclínica em um rebanho de leite com alta prevalência de hiperqueratose (35,3% de casos graves Mastitis consistis one of the main problems of milk production, mainly due to the production losses and the rising cost of milk. In case of severe hyperkeratosis, the teat canal can become an easier barrier for the bacteria to penetrate. The objeSctive of this study was to assess a phototherapy device construct with LED light for prevention and treatment of teat hyperkeratosis in a dairy cattle herd with high prevalence (35.3% of severe cases). 60 primiparous cows were used in the preventive experiment and 30 cows with hyperkeratosis were used in the therapeutic experiment. In both experiments, half of the cows started to be treated in early lactation using the phototherapy device three times per week for 6 weeks. The other cows were the controls. Hyperkeratosis was assessed by scoring and by morphometric analyses of teat images that were taken at baseline and then weekly for 6 consecutive weeks. In the preventive experiment, more images were taken later, between 6 and 7 months of the first lactation. Somatic cell counts (SCC) were performed monthly. In the preventive experiment, the outer diameter of the teat lesions remained constant in the treated group, whereas cows of the control group showed a significant increase at the end of lactation. In the therapeutic groups, no statistical differences for teat hyperkeratosis variables were seen between groups. However, the incidence of subclinical mastitis (SCC > 250 cells/mL) during lactation was lower in the treated group (P<0.05). In conclusion the phototherapy protocol did not prevent the development in primiparous or ameliorate previous hyperkeratosis lesions in cows. However, the prototype was considered useful as an adjunct in preventing the increase in the size of teat hyperkeratosis lesions and also as a way to reduce subclinical mastitis incidence in affected dairy cows.INDEX TERMS: Teat hyperkeratosis, mastitis, phototherapy, LED, dairy cattle.

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Light-emitting Diode Phototherapy at 630.+-.3 nm Increases Local Levels of Skin-homing T-cells in Human Subjects

Abstract: Background and aims: Red light phototherapy with laser sources has been used

Cited by 20 publications

References 20 publications

Effect of 710-nm Visible Light Irradiation on Neuroprotection and Immune Function after Stroke

Effect of 710-nm Visible Light Irradiation on Neuroprotection and Immune Function after Stroke

Combination 830-nm and 633-nm Light-Emitting Diode Phototherapy Shows Promise in the Treatment of Recalcitrant Psoriasis: Preliminary Findings

Dispositivo fotobiomodulador para prevenção e tratamento de hiperqueratose de teto em vacas leiteiras

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