Combination 830-nm and 633-nm Light-Emitting Diode Phototherapy Shows Promise in the Treatment of Recalcitrant Psoriasis: Preliminary Findings

Ablon, Glynis

doi:10.1089/pho.2009.2484

Cited by 44 publications

(21 citation statements)

References 13 publications

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“…PBM has been used for psoriasis because of its anti-inflammatory effects, which is a different approach from UV phototherapy which tends to kill circulating T-cells. Ablon [99] tested PBM using LEDs (830 nm, 60 J/cm 2 and 633 nm, 126 J/cm 2 ) in two 20-min sessions over 4 or 5 weeks, with 48 h between sessions in 9 patients with chronic treatment-resistant psoriasis. Clearance rates at the end of the follow-up period ranged from 60% to 100%.…”

Section: Clinical Applications Of Pbm For Inflammationmentioning

confidence: 99%

Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

2017

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Photobiomodulation (PBM) also known as low-level level laser therapy is the use of red and near-infrared light to stimulate healing, relieve pain, and reduce inflammation. The primary chromophores have been identified as cytochrome c oxidase in mitochondria, and calcium ion channels (possibly mediated by light absorption by opsins). Secondary effects of photon absorption include increases in ATP, a brief burst of reactive oxygen species, an increase in nitric oxide, and modulation of calcium levels. Tertiary effects include activation of a wide range of transcription factors leading to improved cell survival, increased proliferation and migration, and new protein synthesis. There is a pronounced biphasic dose response whereby low levels of light have stimulating effects, while high levels of light have inhibitory effects. It has been found that PBM can produce ROS in normal cells, but when used in oxidatively stressed cells or in animal models of disease, ROS levels are lowered. PBM is able to up-regulate anti-oxidant defenses and reduce oxidative stress. It was shown that PBM can activate NF-kB in normal quiescent cells, however in activated inflammatory cells, inflammatory markers were decreased. One of the most reproducible effects of PBM is an overall reduction in inflammation, which is particularly important for disorders of the joints, traumatic injuries, lung disorders, and in the brain. PBM has been shown to reduce markers of M1 phenotype in activated macrophages. Many reports have shown reductions in reactive nitrogen species and prostaglandins in various animal models. PBM can reduce inflammation in the brain, abdominal fat, wounds, lungs, spinal cord.

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Section: Clinical Applications Of Pbm For Inflammationmentioning

confidence: 99%

Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

2017

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“…Despite the promising cell-biostimulatory results obtained with phototherapy, such as modulation of tissue inflammation (15) and stimulation of fibroblast cell metabolism, odontoblast-like cells, and human pulp cells (10,11,(16)(17)(18), information about the effects of infrared LED on the metabolism and mineralization ability of stem cells from human exfoliated deciduous teeth is scant. Therefore, the aim of this study was to evaluate the effects of 850-nm LED irradiation on cultured stem cells from human exfoliated deciduous teeth (SHEDs) at different energy densities.…”

Section: Introductionmentioning

confidence: 99%

Dose-responses of Stem Cells from Human Exfoliated Teeth to Infrared LED Irradiation

et al. 2015

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Despite several reports regarding tissue regeneration, including pulp repair induced by different light sources, only limited data have been reported concerning the effects of light-emitting diodes (LED) on stem cells from human exfoliated deciduous teeth (SHEDs). The aim of this study was to evaluate the effects of different energy densities of infrared LED on the cell viability, number of cells and mineralized tissue production by SHEDs. SHEDs were obtained from near-exfoliation primary teeth (n=3), seeded in plain DMEM (10 4 cells/cm 2 ), and irradiated by a LED prototype (LEDTable 850 nm, 40 mW/cm 2 ) delivering 0 (control), 2, 4, 8, 15 or 30 J/cm 2 (n=9). Cell viability (MTT assay), cell proliferation (trypan blue assay), and mineralized nodule (MN) formation (alizarin red stain) were assessed 12 and 72 h post-irradiation. Data were subjected to Kruskal-Wallis and Mann-Whitney tests (α=0.05). Cells irradiated with 2 or 4 J/cm 2 exhibited higher metabolism at 72 h, and all energy densities provided increase in cell proliferation after 12 h. Regarding MN formation, the best results were observed at 72 h after SHED irradiation with 8 and 15 J/cm 2 . It was concluded that the cell viability, cell number and MN formation by pulp cells are enhanced after exposure to infrared LED irradiation. Overall, the greatest SHED biostimulation was obtained with 4 and 8 J/cm 2 . D o s e -r e s p o n s e s o f S t e m C e l l s f r o m H u m a n E x f o l i a t e d Te e t h t o I n f r a r e d L E D I r r a d i a t i o n

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“…). Studies have demonstrated that light at the wavelength in the infrared region could exert an anti‐inflammatory effect (Ablon ), increase cell metabolism (Vinck et al . , Oliveira et al .…”

Section: Introductionmentioning

confidence: 99%

Infrared LED irradiation photobiomodulation of oxidative stress in human dental pulp cells

et al. 2013

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Combination 830-nm and 633-nm Light-Emitting Diode Phototherapy Shows Promise in the Treatment of Recalcitrant Psoriasis: Preliminary Findings

Cited by 44 publications

References 13 publications

Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

Dose-responses of Stem Cells from Human Exfoliated Teeth to Infrared LED Irradiation

Infrared LED irradiation photobiomodulation of oxidative stress in human dental pulp cells

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