Light-emitting diodes at 940 nm attenuate colitis-induced inflammatory process in mice

Belém, Mônica de Oliveira; Andrade, Giovana M.M. de; Carlos, Thalita M.; Guazelli, Carla F. S.; Fattori, Victor; Filho, D. O. Toginho; Dias, Ivan Frederico Lupiano; Verri, Waldiceu A.; Araújo, Eduardo J.A.

doi:10.1016/j.jphotobiol.2016.07.008

Cited by 7 publications

(2 citation statements)

References 48 publications

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“…The purpose of this study was to determine whether a combination of the following two wavelengths would be effective for OA: (1) 850 nm, which is the middle wavelength of the two studies (830 and 870 nm) that reported a therapeutic effect for OA, and (2) 940 nm, which is the 900 nm wavelength region that has reported stimulatory effects on osteogenesis and several other conditions such as RA, and colitis [18,20,22,30,31]. We referred to previous studies that examined the interactions between light and tissue, specifically considering the intensity and duration of exposure to light-based devices [15].…”

Section: Discussionmentioning

confidence: 99%

“…Inflammatory responses and oxidative stresses were reduced in burn wounds after 850 nm wavelength LED treatment, which promotes wound healing [17]. It has the effect of reducing pro-inflammatory cytokines in mice with colitis after 940 nm wavelength LED treatment [18]. Prior study highlighted that combining LED wavelengths is more effective than using a single wavelength alone in skin lesion [19].…”

Section: Introductionmentioning

confidence: 99%

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Preclinical Study of Dual-Wavelength Light-Emitting Diode Therapy in an Osteoarthritis Rat Model

Choi,

Kim,

Kim

et al. 2023

Ann Rehabil Med

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Objective: To evaluate the efficacy of light-emitting diode (LED) and their dual-wavelengths as a treatment strategy for osteoarthritis.Methods: We induced osteoarthritis in male Sprague-Dawley rats by intra-articular injection of sodium iodoacetate into the right rear knee joint. The animals with lesions were divided into an untreated group and an LED-treated group (n=7 each). In the LED-treated group, the lesioned knee was irradiated with lasers (850 and 940 nm) and dose (3.15 J/cm<sup>2</sup>) for 20 minutes per session, twice a week for 4 weeks. Knee joint tissues were stained and scanned using an in vivo micro-computed tomography (CT) scanner. Serum interleukin (IL)-6 and IL-18 levels were determined using enzyme-linked immuno-sorbent assay. Several functional tests (lines crossed, rotational movement, rearing, and latency to remain rotating rod) were performed 24 hours before LED treatment and at 7, 14, 21, and 28 days after treatment.Results: LED-treated rats showed improved locomotor function and suppressed matrix-degrading cytokines. Micro-CT images indicated that LED therapy had a preserving effect on cartilage and cortical bone.Conclusion: LED treatment using wavelengths of 850 and 940 nm resulted in significant functional, anatomical, and histologic improvements without adverse events in a rat model. Further research is required to determine the optimal wavelength, duration, and combination method, which will maximize treatment effectiveness.

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