Modulation of exercise-induced muscular damage and hyperalgesia by different 630 nm doses of light-emitting diode therapy (LEDT) in rats

Vasconcelos, Alan Bruno Silva; Nampo, Fernando Kenji; Molina, Julio Cesar Correa; Silva, Miriam B; Oliveira, Alan Santos; Angelis, Tarlyson R de; Hasuda, Amanda Lopes; Camargo, Enilton A.; Ramos, Solange P.

doi:10.1007/s10103-018-2655-x

Cited by 4 publications

(13 citation statements)

References 52 publications

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“…Experimental and clinical trials with red and nearinfrared light have already demonstrated the reduction in CK levels and signs of EIMD (4,6,16,45), corroborating our findings. Some mechanisms that may explain the effect of phototherapy on muscle damage prevention include the reduction in inflammation, decreased oxidative stress, inhibition of cellular apoptosis and muscle necrosis, improved local microcirculation, and improved ATP synthesis (25,32,41,45). At 72 hours after the first bout, serum CK activity was attenuated in the LEDT 940-nm group compared with the placebo, which is aligned with other studies that used near-infrared and combined red and infrared light in upper and lower limb exercises (16,19), suggesting that phototherapy was effective in attenuating muscle damage at 72 hours.…”

Section: Discussionsupporting

confidence: 89%

“…The irradiation parameters are described in Table 1. The mean energy density applied per point ranged between energy doses proven to inhibit or decrease EIMD in experimental studies (6,12,45). Subjects wore opaque glasses and earphones to avoid identification of which treatment was applied.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, some experimental evidence has suggested that phototherapy may have beneficial effects on postexercise recovery, reducing or preventing EIMD (6,12,13,45). A clinical study also suggested that this method may be useful for accelerating recovery after eccentric or isometric muscle-damaging contractions (4,16,36).…”

Section: Introductionmentioning

confidence: 99%

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Phototherapy Improves Muscle Recovery and Does Not Impair Repeated Bout Effect in Plyometric Exercise

Padoin

Zeffa

Correa

et al. 2020

Journal of Strength and Conditioning Research

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Padoin, S, Zeffa, AC, Molina Corrêa, JC, de Angelis, TR, Moreira, TB, Barazetti, LK, and de Paula Ramos, S. Phototherapy improves muscle recovery and does not impair repeated bout effect in plyometric exercise. J Strength Cond Res 36(12): 3301–3310, 2022—The effects of photobiomodulation with red (630 nm) and near-infrared (940 nm) light wavelengths were investigated on the inhibition of exercise-induced muscle damage (EIMD) and adaptation to the repeated bout effect (RBE). Twenty-eight healthy men were randomized to receive light-emitting diode therapy (LEDT) at 630 nm (4.6 J·cm−2, 97 J energy), LEDT at 940 nm (4.6 J·cm−2, 114 J), or placebo. After LEDT or placebo treatment, subjects performed 100 drop-jumps (5 sets of 20 repetitions). Creatine kinase, delayed-onset muscle soreness (DOMS), countermovement jump (CMJ), and squat jump (SJ) were assessed before, immediately after, and 24, 48, and 72 hours after the bout. After 14 days, the subjects were submitted to the same plyometric exercise, without LEDT, and were evaluated again. Creatine kinase levels increased significantly 72 hours after the first bout in the placebo group in relation to the LEDT 940-nm group (P < 0.01). The LEDT 630-nm group showed a significant increase in SJ at 24 hours (P < 0.05), whereas, at 48 hours, the LEDT 940 nm showed a significant increase compared with the placebo group (P < 0.05). The 2-way analysis of variance revealed an effect for treatment in the SJ (F = 7.12; P = 0.001). No differences were found between groups for DOMS and CMJ after the first bout. After the second bout of exercise, there was no effect of treatment. The results suggest that treatment with LEDT 630 nm and LEDT 940 nm before eccentric exercise attenuates EIMD without impairing RBE.

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Section: Discussionsupporting

confidence: 89%

Section: Methodsmentioning

confidence: 99%

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Phototherapy Improves Muscle Recovery and Does Not Impair Repeated Bout Effect in Plyometric Exercise

Padoin

Zeffa

Correa

et al. 2020

Journal of Strength and Conditioning Research

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“…In a study using a muscle injury model by trauma in Wistar rats, Silveira and colleagues [51] also found an increase in the CK in the group without irradiation and a reduction in levels with the administration of PBM at the injury site (904 nm, 40 mW, 60 ns, 9500 Hz, 2.5 J) after 5 days. Moreover, an in vivo study with rats evaluated the effect of PBM with LED administered locally (630 nm, 300 mW, 1.8, 6.3, or 15 J) in an exercise muscle injury and found that all treated groups had CK levels close to that of the control group [10], as occurred in the present investigation.…”

Section: Discussionsupporting

confidence: 76%

“…Therefore, here is a constant quest for therapeutic tools that can decrease the time for the muscle repair and increase the quality of the newly formed tissue. Photobiomodulation (PBM) therapy administered with distinct light sources locally, over the injury site, is one such tool that has demonstrated positive effects in skeletal muscle repair in both clinical and experimental studies [9–16]. PBM acts enhancing the number of newly formed muscle fiber [12, 14, 17–19], decreasing the size of the injury [20–22], and restoring the muscle function when administrated either preventively (before the occurrence of an injury) [14–16, 19, 23–25] or after the injury [12, 13, 22, 26, 27].…”

Section: Introductionmentioning

confidence: 99%

Histological and biochemical effects of preventive and therapeutic vascular photobiomodulation on rat muscle injury

Lopez

Rodrigues

Bach

et al. 2022

Journal of Biophotonics

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The intravascular or transcutaneous application of photobiomodulation (PBM) over blood vessels (vascular photobiomodulation, VPBM) has been used for the treatment of inflammatory and chronic conditions with promising systemic results. This study evaluated the VPBM effects on a model of muscle regeneration after acute injury and compared the outcomes of preventive and therapeutic VPBM. Transcutaneous VPBM was administered over the rat's main tail vein. Serum levels of creatine kinase (CK), aspartate aminotransferase (AST), and lactate were evaluated and muscles were processed for macroscopic and microscopic analysis. Preventive and therapeutic VPBM led to decreased inflammatory infiltrate, edema, and myonecrosis but with an increase in immature muscle fibers. CK, AST, and lactate levels were lower in the groups treated with VPBM (lowest concentrations in preventive VPBM application). Preventive and therapeutic VPBM were capable of exerting a positive effect on acute muscle injury repair, with more accentuated results when preventive VPBM was administered.

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Light-emitting diode phototherapy: pain relief and underlying mechanisms

et al. 2022

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Modulation of exercise-induced muscular damage and hyperalgesia by different 630 nm doses of light-emitting diode therapy (LEDT) in rats

Cited by 4 publications

References 52 publications

Phototherapy Improves Muscle Recovery and Does Not Impair Repeated Bout Effect in Plyometric Exercise

Phototherapy Improves Muscle Recovery and Does Not Impair Repeated Bout Effect in Plyometric Exercise

Histological and biochemical effects of preventive and therapeutic vascular photobiomodulation on rat muscle injury

Light-emitting diode phototherapy: pain relief and underlying mechanisms

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