Light microscopic autoradiographic study of DNA synthesis in cecal epithelial cells of aging mice.

Jin, Chunji; Nagata, Tetsuya

doi:10.1177/43.12.8537638

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Cited by 8 publications

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Electron microscopic radioautographic studies on DNA synthesis and the ultrastructure of the adrenal gland in aging mice

Itô

Nagata

1996

Med Electron Microsc

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The changes in DNA synthesis of adrenal gland cells in aging mice from prenatal day 19 to postnatal 2 years were observed by electron microscopic radioautography. The percentages of labeled ceils (labeling indices) in the zona glomerulosa, zona fasciculata and zona reticularis of the cortex and the medulla after 3H-thymidine injection were at their maxima during the perinatal stage and then gradually decreased with age. The ultrastructural features of the cells at the late embryonic and early postnatal stages appeared undeveloped. Well-developed cell organelles, such as smooth surfaced endoplasmic reticulum, mitochondria with tubular or vesicular cristae and lipid droplets, were more frequently observed in the cytoplasm of the unlabeled cells than in the labeled ceils in the three zones of the cortex.

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