Light-scattering patterns of the vitreous humor

Bettelheim, Frederick A.; Balazs, Endre A.

doi:10.1016/0304-4165(68)90152-9

Cited by 20 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is easy to show and to understand that the light that strikes the retina around the image of a bright light source is light scattered from the materials in the eye and from its surface. Recently, the forward scattering has been measured in vitro with laser light (1,2), and partially treated theoretically (3).…”

Section: Introductionmentioning

confidence: 99%

In vivo measurements of the viscoelasticity of the human vitreous humor

Zimmerman¹

1980

Biophysical Journal

View full text Add to dashboard Cite

A point of source of light against a dark background is perceived by the human retina as a point image enhanced by off-axis points (rays if the source is polychromatic) of light scattered from objects along the optic axis. As a consequence of movement of the vitreous humor, scattering centers imbedded there impart of this scattering pattern a corresponding movement. A method has been devised to give the vitreous humor reproducible initial conditions and to record the observed relaxation of the scattering pattern to its new rest position. The vitreous humor is found to be overdamped, and the heretofore unreported shear elastic modulus has been determined. A striking gravitational effect is revealed by comparing observations along a horizontal optic axis with ones along a vertical optic axis. For the former, gravitational torque is found to dominate the elastic torque. The reason nature has developed a slow-responding gravitational sensor in the vitreous humor is not clear.

show abstract

Section: Introductionmentioning

confidence: 99%

In vivo measurements of the viscoelasticity of the human vitreous humor

Zimmerman¹

1980

Biophysical Journal

View full text Add to dashboard Cite

show abstract

“…The highly hydrated glycosaminoglycan chains separate the small-diameter fibers. In this way, light can transmit to the retina with small scattering [25].…”

Section: Biochemical Properties Of Vitreousmentioning

confidence: 99%

Polymeric hydrogel as a vitreous substitute: current research, challenges, and future directions

Wang¹,

Ran²,

Ma³

et al. 2021

Biomed. Mater.

View full text Add to dashboard Cite

Vitreoretinal surgery is an essential approach to treat proliferative diabetic vitreopathy, retinal detachment, retinal tear, ocular trauma, and macular holes. The removal of the natural vitreous and the replacement with substitutes are critical steps for retina reattachment. Vitreous substitutes including silicone oil (SiO), air, sulfur hexafluoride (SF6), and perfluoropropane (C3F8), have been widely applied in clinical practice. However, these substitutes are reported to cause complications such as emulsification, high intraocular pressure, and lens opacification. Polymeric hydrogels are a kind of material with favorable physical, mechanical properties, and adaptable biocompatibility, thus being highly expected to be ideal vitreous substitutes. Despite years of research, very few polymeric hydrogels can be applied practically in the vitreous cavity. In this review, we focus on the development of polymeric natural-based hydrogels and synthetic hydrogels. Particularly, we pay attention to recent advances in the novel stimuli-response and self-assembly supramolecular hydrogels. Characterized by easy injectability and long residence time, this kind of hydrogel becomes the potentially promising candidates for ideal vitreous substitutes. Finally, we evaluate the current challenges and provide the future directions of vitreous substitutes.

show abstract

“…Attempts to analyse the structure of the vitreous with optical methods date back to Bettelheim & Balasz (1968). Those experiments were conducted with methods of static light scattering.…”

Section: Introductionmentioning

confidence: 99%

Analysis of diabetic vitreopathy with dynamic light scattering spectroscopy – problems and solutions related to photon correlation

Fankhauser

2012

Acta Ophthalmologica

View full text Add to dashboard Cite

. Purpose: To explore the molecular alterations of the vitreous by dynamic light scattering (DLS) spectroscopy (quasi‐elastic light scattering spectroscopy, photon‐correlation spectroscopy) in normals and in patients afflicted with various degrees of non‐proliferative and with proliferative diabetic retinopathy. Methods: Dynamic light scattering spectroscopy was employed to analyze the vitreous of normals and of patients with diabetes non‐invasively to estimate both the sizes and diffusion coefficients of mobile macromolecules and/or microparticles. Results: Abnormal molecular behaviour of vitreous molecules was observed in patients with diabetes afflicted with various degrees of diabetic vitreo‐retinopathy. In the non‐proliferative (background) retinopathy, both the diameters of the microparticles increase and the diffusion constants decrease significantly and progressively as the diabetic disease progresses. In the proliferative phase, a significant trend in the direction of smaller particles and greater diffusion constants is evident. These behaviours could also be interpreted as an increase in the viscosity of the intermolecular substance in the first case and as a decrease in the second. Conclusions: The vitreous in normals and even more so in diabetics with diabetic vitreo‐retinopathy is optically a highly non‐isotropic, multidispersive structure, making an optical analysis difficult. Advanced, but available models and technology, however, permits a major step forward in the optical analysis of the normal and the diseased vitreous.

show abstract

Light-scattering patterns of the vitreous humor

Cited by 20 publications

References 5 publications

In vivo measurements of the viscoelasticity of the human vitreous humor

In vivo measurements of the viscoelasticity of the human vitreous humor

Polymeric hydrogel as a vitreous substitute: current research, challenges, and future directions

Analysis of diabetic vitreopathy with dynamic light scattering spectroscopy – problems and solutions related to photon correlation

Contact Info

Product

Resources

About