Light Tests and Pathogenetic Wavelengths in Chronic Polymorphous Light Dermatosis

Verhagen, A.R.H.B.

doi:10.1159/000254343

Cited by 19 publications

(6 citation statements)

References 8 publications

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“…the 'border' zone between short and long UVR. Our present results support the views expressed by Wiskemann & Wulf (1959); Stevanovic (i960); Magnus (1964); and Verhagen (1966), that the action spectrum in PLE was not confined to the short UV wavelengths below 320 nm. Blum (1941), in a review of the literature up to that time, stated that most of the cases of PLE responded 'abnormally to the sunburn spectrum, but in a few cases one must conclude that the sensitivity is due to other wavelengths.…”

Section: Discussionsupporting

confidence: 92%

“…' Epstein (1942) and Epstein (1966) continued to support this view, the latter author finding that the action spectrum in his personal series of eighty-five patients was confined to the sunburn range (290-320 nm). Our present results support the views expressed by Wiskemann & Wulf (1959); Stevanovic (i960); Magnus (1964); and Verhagen (1966), that the action spectrum in PLE was not confined to the short UV wavelengths below 320 nm.…”

Section: Discussionsupporting

confidence: 92%

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The action spectrum in polymorphic hght eruption

et al. 1973

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

The action spectrum in polymorphic hght eruption

et al. 1973

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“…Most patients with PLE have a normal MED value 27,28 although a significant number may exhibit a lowered MED value to UVA or UVB 29,30 . Reproduction of PLE lesions may occur with monochromator phototesting when using multiples of MED, or with polychromatic UV radiation (UVR) when exposing larger areas of the skin 12,31,32 . The results, however, are variable and not always reproducible.…”

Section: Aetiology and Pathogenesismentioning

confidence: 99%

Polymorphous light eruption

Stratigos

Antoniou

Katsambas

2002

Acad Dermatol Venereol

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Polymorphous light eruption (PLE) is a common idiopathic photosensitivity disorder with an estimated prevalence of 10-20%. It is characterized by an intermittent skin reaction to ultraviolet (UV) radiation exposure, consisting of non-scarring pruritic erythematous papules, vesicles or plaques that develop on light-exposed skin. Despite the different morphology in different individuals, the eruption tends to have a monomorphous presentation in any single subject. The histopathological features of PLE are distinct and comprise a perivascular lymphocytic infiltrate in the dermis, subepidermal oedema and variable epidermal changes. The pathogenesis of PLE is not well known, but findings suggest that it is a delayed-type hypersensitivity reaction to one or more UV-modified cutaneous antigens. The principal action of PLE is mainly in the UVA region, although some subjects exhibit sensitivity to UVB alone or to both UVA and UVB radiation at the same time. Preventive measures in PLE include the regular use of photoprotective methods combined with graduated exposures to natural sunlight. The induction of immune tolerance by phototherapy and photochemotherapy are useful prophylactic methods in moderate to severe cases. The role of systemic agents in the management of PLE is under investigation. This article reviews the epidemiological, pathogenetic and clinical aspects of PLE and discusses recent advances in the diagnostic approach and management of this condition.

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“…Light testing in PMLE has been used to diagnose the disease and to determine its action spectrum. The biologic action spectrum for PMLE has been reported to be predominantly within the UV-B region (Epstein, 1966a;t962), but to extend to UV-A (315-400 nm) and visible light (Frain-Bell et al, 1973;Frain-Bell, Mckenzie & Witham, 1969;Verhagen, 1964) as well. Two types of light testing procedures are used for diagnostic purposes.…”

Section: The Role Of Light Testing In Pmlementioning

confidence: 99%

The role of histopathology in polymorphous light eruption light testing

et al. 1981

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Summary Provocative light testing was performed in ten patients with polymorphous light eruption (Pmle) and in ten normal subjects to determine whether the histopathology of irradiated test sites could be used as an end point for a positive response. Three separate test sites on the lower back were irradiated (UV‐B) with a single exposure to i minimal erythema dose (MED), a single exposure to 5 x MED, or three consecutive daily exposures to 3 x MED. Biopsies of all test sites were coded and examined without knowing if the biopsy was from a normal subject or a patient with Pmle. In no case was a rash reproduced by light testing. A spectrum of histologic features were observed at the three test sites in both normal subjects and patients with Pmle with no significant differences noted between the two groups. It was concluded that the histology at these UV‐B irradiated test sites could not be used as an endpoint Pmle for testing. In establishing Pmle light testing techniques which rely on histology it is mandatory to include adequate numbers of normal controls.

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Light Tests and Pathogenetic Wavelengths in Chronic Polymorphous Light Dermatosis

Cited by 19 publications

References 8 publications

The action spectrum in polymorphic hght eruption

The action spectrum in polymorphic hght eruption

Polymorphous light eruption

The role of histopathology in polymorphous light eruption light testing

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