Light-triggered nitric oxide (NO) release from photoresponsive polymersomes for corneal wound healing

Duan, Yutian; Wang, Yong; Li, Xiaohu; Zhang, Guozhen; Zhang, Guoying; Hu, Jinming

doi:10.1039/c9sc04039k

Cited by 82 publications

(66 citation statements)

References 59 publications

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“…As such, it is of crucial importance to develop NO-releasing materials capable of delivering NO to specific pathological sites and releasing NO on-demand with a proper concentration. In this regard, much effort has been dedicated to various NO-releasing small molecules and nanovectors, including organic-inorganic hybrid materials, macromolecular assemblies, and so on [ 20 , 21 ]. Recently, with the rapid development of MOFs, the high porosity, large surface area, and easy structural adjustment make them promising candidates for NO delivery [ 22 ].…”

Section: Mofs For the Delivery Of Nitric Oxidementioning

confidence: 99%

Engineering Metal–Organic Frameworks (MOFs) for Controlled Delivery of Physiological Gaseous Transmitters

Zhang

Qiao

2020

Nanomaterials

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Metal–organic frameworks (MOFs) comprising metal ions or clusters coordinated to organic ligands have become a class of emerging materials in the field of biomedical research due to their bespoke compositions, highly porous nanostructures, large surface areas, good biocompatibility, etc. So far, many MOFs have been developed for imaging and therapy purposes. The unique porous nanostructures render it possible to adsorb and store various substances, especially for gaseous molecules, which is rather challenging for other types of delivery vectors. In this review, we mainly focus on the recent development of MOFs for controlled release of three gaseous transmitters, namely, nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). Although these gaseous molecules have been known as air pollutants for a long time, much evidence has been uncovered regarding their important physiological functions as signaling molecules. These signaling molecules could be either physically absorbed onto or covalently linked to MOFs, allowing for the release of loaded signaling molecules in a spontaneous or controlled manner. We highlight the designing concept by selective examples and display their potential applications in many fields such as cancer therapy, wound healing, and anti-inflammation. We hope more effort could be devoted to this emerging fields to develop signaling molecule-releasing MOFs with practical applications.

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Section: Mofs For the Delivery Of Nitric Oxidementioning

confidence: 99%

Engineering Metal–Organic Frameworks (MOFs) for Controlled Delivery of Physiological Gaseous Transmitters

Zhang

Qiao

2020

Nanomaterials

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“…Photo-responsive polymersomes (i.e., polymer vesicles) have attracted great interest as controlled drug delivery systems since they can realize spatial and temporal control of the release of the encapsulated therapeutics on demand via light irradiation [1][2][3]. The key to constructing these polymersomes is to confer amphiphilic block copolymers with photo-responsiveness by introducing photosensitive moieties called chromophores into polymer chains.…”

Section: Introductionmentioning

confidence: 99%

Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications

Hou

Liu

et al. 2020

Molecules

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Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pure poly (o-nitrobenzyl acrylate) (PNBA) as the hydrophobic block and poly (N,N’-dimethylacrylamide) (PDMA) as the hydrophilic block using bulk reversible addition-fragmentation chain transfer (RAFT) polymerization of o-nitrobenzyl acrylate using a PDMA macro-RAFT agent. The developed amphiphilic block copolymers have a suitable hydrophobic/hydrophilic ratio and can self-assemble into photoresponsive polymersomes for co-loading hydrophobic and hydrophilic cargos into hydrophobic membranes and aqueous compartments of the polymersomes. The polymersomes demonstrate a clear photo-responsive characteristic. Exposure to light irradiation at 365 nm can trigger a photocleavage reaction of o-nitrobenzyl groups, which results in dissociation of the polymersomes with simultaneous co-release of hydrophilic and hydrophobic cargoes on demand. Therefore, these polymersomes have great potential as a smart drug delivery nanocarrier for controllable loading and releasing of hydrophilic and hydrophobic drug molecules. Moreover, taking advantage of the conditional releasing of hydrophilic and hydrophobic drugs, the drug delivery system has potential use in medical applications such as cancer therapy.

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“…4 Unfortunately, antibiotics are oen abused in clinical treatment, which has resulted in the emergence of a number of multi-resistant bacteria that are harmful to humans. 5 Thus, alternative methods that can inhibit these multi-resistant bacteria are highly needed. 6 What's more, bacterial infection is not the only cause that blocks the healing of skin wounds; UV-induced injury is also a large obstacle.…”

Section: Introductionmentioning

confidence: 99%

The synthesis of a DHAD/ZnAlTi-LDH composite with advanced UV blocking and antibacterial activity for skin protection

Fan

Lin

et al. 2020

RSC Adv.

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Light-triggered nitric oxide (NO) release from photoresponsive polymersomes for corneal wound healing

Abstract: Nitric oxide-releasing amphiphiles are successfully synthesized through direct polymerization and are engineered as photoresponsive polymersomes for biomedical applications.

Cited by 82 publications

References 59 publications

Engineering Metal–Organic Frameworks (MOFs) for Controlled Delivery of Physiological Gaseous Transmitters

Engineering Metal–Organic Frameworks (MOFs) for Controlled Delivery of Physiological Gaseous Transmitters

Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications

The synthesis of a DHAD/ZnAlTi-LDH composite with advanced UV blocking and antibacterial activity for skin protection

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