Lignan Glucosides and Serotonin Phenylpropanoids from the Seeds of Leuzea carthamoides

Many of disease-modifying anti-rheumatic drugs often have side effects at high doses and/or during long-term administration. Increased efficacy without increased toxicity is expected for combination therapy of rheumatoid arthritis (RA). The aim of the study was to examine the effect of N-feruloylserotonin (N-f-5HT) and methotrexate (MTX) in monotherapy and in combination therapy on disease progression and inflammation in arthritic rats. Adjuvant arthritis was induced by intradermal injection of Mycobacterium butyricum in incomplete Freund's adjuvant in Lewis rats. The experiment included healthy animals, arthritic animals without any drug administration, arthritic animals with administration of N-f-5HT in the oral daily dose of 15 mg/kg b.w., arthritic animals with administration of MTX in the oral dose of 0.3 mg/kg b.w. twice a week and arthritic animals treated with the combination of N-f-5HT and MTX. N-f-5HT in monotherapy reduced only activation of NF-κB and did not have any significant effect on other parameters monitored. Low-dose treatment of MTX decreased the level of IL-1β and MCP-1 on day 14 and activation of NF-κB in liver without significant effect on other parameters. N-f-5HT and MTX combination showed both the anti-arthritic (hind paw volume and arthritic score) and anti-inflammatory effect (plasmatic levels of IL-1β, IL-17, MCP-1, CRP, and activation of NF-κB in liver). In combination with MTX, N-f-5HT markedly potentiated the therapeutic effect of MTX low dose, which resulted in significant improvement of all parameters measured. The findings showed that the combination therapy simultaneously decreased multiple markers of inflammation, a result crucial for future therapy of RA.

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“…The purity, analyzed by HPLC [27], was over 96%. The MS and NMR spectra were identical with the data reported in [28].…”

Section: Preparation Of N-feruloylserotoninsupporting

confidence: 60%

N‐feruloylserotonin in preventive combination therapy with methotrexate reduced inflammation in adjuvant arthritis

Kuncírová

Poništ

Mihalová

et al. 2014

Fundamemntal Clinical Pharma

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“…Its extracts are often used for prevention of cardiovascular and gastrointestinal diseases, as well as the reduction of stress, generally, by increasing the individual's immunity and resistance (Opletal et al, 1997). Using Leuzea seeds, we isolated a crystalline fraction containing N-feruloylserotonin isomers, which are phenylpropanoids conjugated with serotonin, and are structurally similar to melatonin (Harmatha et al, 2007). The structural features and quantitative composition of this fraction, which contains four isomeric compounds (geometric E and Z isomers of N-feruloylserotonin and N-iso-feruloylserotonin), have been fully characterized (Pavlík et al, 2002;Harmatha et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Using Leuzea seeds, we isolated a crystalline fraction containing N-feruloylserotonin isomers, which are phenylpropanoids conjugated with serotonin, and are structurally similar to melatonin (Harmatha et al, 2007). The structural features and quantitative composition of this fraction, which contains four isomeric compounds (geometric E and Z isomers of N-feruloylserotonin and N-iso-feruloylserotonin), have been fully characterized (Pavlík et al, 2002;Harmatha et al, 2007). This crystalline fraction, containing N-(E)-iso-feruloylserotonin as the major component, was used in our experiments.…”

Section: Introductionmentioning

confidence: 99%

The selective effect of N-feruloylserotonins isolated from Leuzea carthamoides on nociception and anxiety in rats

Yamamotová

Pometlová

Harmatha

et al. 2007

Journal of Ethnopharmacology

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“…Particularly, CS and FS are the most well-known and possess the simplest structures among the PAHA types, and both of them contain both cis-and trans-isomers. The content of trans-isomers in plants is usually much higher than the content of cis-isomers [61].…”

Section: Varieties and Structures Of Pahamentioning

confidence: 98%

Characteristics of Specialty Natural Micronutrients in Certain Oilseeds and Oils: Plastochromanol‐8, Resveratrol, 5‐Hydroxytryptamine Phenylpropanoid Amides, Lanosterol, Ergosterol and Cyclolinopeptides

Jin

Sheraliev

Xie

et al. 2015

J Americ Oil Chem Soc

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The current concern for health has raised the importance of natural micronutrients in edible oils and fats. Different from common micronutrients, e.g., tocopherols, tocotrienols, stigmasterol and sitosterol, new and emerging specialty micronutrients, such as plastochromanol‐8, resveratrol, phenylpropanoid amides of 5‐hydroxytryptamine, lanosterol, ergosterol and cyclolinopeptides, are becoming increasingly popular among health‐conscious people. The first three are phenolic compounds, the forth and fifth sterols, and sixth a peptide. These micronutrients are usually present in certain oils or oilseed‐related byproducts, including rapeseed, peanut, flaxseed, tea seed, and camellia oils, and safflower seed cakes, all of which are the highly valuable products of the lipid industry in China nowadays. The first object of this review is to discuss the characteristics of the micronutrients, mainly including their varieties, structures, and sources. Second, the antioxidant activities and indicative functions for oil quality were also analyzed in detail. Third, refining techniques, breeding programs and extraction methods are suggested. Suitable modification treatments of certain micronutrients are also advocated to make them easy to incorporate in other foods.

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Lignan Glucosides and Serotonin Phenylpropanoids from the Seeds of Leuzea carthamoides

Cited by 27 publications

References 32 publications

N‐feruloylserotonin in preventive combination therapy with methotrexate reduced inflammation in adjuvant arthritis

N‐feruloylserotonin in preventive combination therapy with methotrexate reduced inflammation in adjuvant arthritis

The selective effect of N-feruloylserotonins isolated from Leuzea carthamoides on nociception and anxiety in rats

Characteristics of Specialty Natural Micronutrients in Certain Oilseeds and Oils: Plastochromanol‐8, Resveratrol, 5‐Hydroxytryptamine Phenylpropanoid Amides, Lanosterol, Ergosterol and Cyclolinopeptides

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