Lignan Glycosides and Phenolic Compound Glycosides from the Branches of <i>Tabebuia chrysotricha</i>

Abstract

From the branches of Tabebuia chrysotricha (Bignoniaceae), two lignan glycosides (1, 2) and two phenolic compound glycosides (3, 4) were isolated, along with 15 known compounds (5 -19). The structures of the new compounds were elucidated on the basis of spectroscopic evidence and those of the known compounds were identified by comparison of spectroscopic data with those reported in the literature. The DPPH radical-scavenging activity was assayed for the compounds isolated, the aryltetralin-type lignans showing moderate activity.

Recent advances in research on lignans and neolignans

“…Schisanwilsonins A-C (52-54), D (57), E (55), F (56) and G (58) have been reported from the same plant species originating from the Yunnan province in People's Republic of China. 35 More recently, Yang et al 36 investigated the fruits of S. wilsoniana that further led to the isolation of the dibenzocyclooctadiene lignans, marlignans M-S (59)(60)(61)(62)(63)(64)(65). Their cytotoxicity was measured in addition to determining their antiviral activity, using AZT as a positive control (EC 50 ¼ 0.0043 mg mL À1 and CC 50 > 200 mg mL À1 ).…”

“…Furthermore, they exhibited signicant antiproliferative activity against Paracentrotus lividus. 60 Sun et al 61 63 Other aryltetralin lignans include compound 165 and its methyl ether analog 166 isolated from Holostylis reniformis (Aristolochiaceae) 64 and the aryltetrahydronaphthalene (+)-cycloolivil formaldehyde condensate (167) obtained from the whole plants of Epimedium brevicornum (Berberidaceae). 65 Arisantetralones A-D (179)(180)(181)(182) are among the lignans isolated from the fruits of Schisandra arisanensis.…”

“…62 The aryltetralin-type lignan glycosides 163 and 164, isolated from the branches of Tabebuia chrysotricha (Martius ex De Candolle) Standley (Bignoniaceae), showed moderate DPPH radical-scavenging activity (IC 50 of 44 and 35 mM, respectively) compared to Trolox used as a positive control (IC 50 of 17 mM). 63 Other aryltetralin lignans include compound 165 and its methyl ether analog 166 isolated from Holostylis reniformis (Aristolochiaceae) 64 and the aryltetrahydronaphthalene (+)-cycloolivil formaldehyde condensate (167) obtained from the whole plants of Epimedium brevicornum (Berberidaceae). 65 4,5-Didemethylpodophyllotoxin 7 0 -O-b-D-glucopyranoside (168), one of the constituents of the n-butanol extract of roots and rhizomes of Sinopodophyllum emodi, showed in vitro cytotoxicity against four human cancer cell lines (Hela, K562, SH-SY5Y and CNE).…”