Lignanas e triterpenos do extrato citotóxico de Eriope blanchetii

David, Juceni P.; Silva, Eliana F. da; Moura, Daniel Lima de; Guédès, Michel; Assunção, Roberval de Jesus; David, Jorge

doi:10.1590/s0100-40422001000600004

Cited by 29 publications

(24 citation statements)

References 4 publications

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“…De acordo com David et al (2001), a classificação de substâncias puras obtidas de extratos de plantas, quanto à sua atividade citotóxica em A. salina, correlacionando com atividade anticancerígena, pode ser assim atribuídas: substâncias que apresentam DE 50 >1000 µg/mL são consideradas inativas e aquelas com DE 50 <100 µg/ mL são muito ativas, comparáveis à camptotecina e ao sulfato de vincristina, substâncias usadas no tratamento de leucemia (Schripsema et al, 2004). Siqueira et al (1998) observaram a validade e confiabilidade do bioensaio da A. salina, em estudo de toxicidade de frações de Unonopsis lindmanii que continham substâncias reconhecidamente ativas sobre células tumorais in vitro (Ceplenau, 1993;Valter et al, 2008).…”

Section: Discussionunclassified

Composição química e toxicidade frente Aedes aegypti L. e Artemia salina Leach do óleo essencial das folhas de Myrcia sylvatica (G. Mey.) DC.

Rosa

Veras

Silva

et al. 2016

Rev. bras. plantas med.

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Mortality data were evaluated by linear regression to determine the LC 50 . Was obtained 0.5% yield values, and (E) -caryophyllene the major constituent. The essential oil showed a LC 50 = 79.44 mg / mL front A. saline and is considered highly toxic. However, this oil showed no effect on larvae of A. aegypti. Whereas the brine shrimp test has regard to several biological activities, as antitumoral property, the essential oil from the leaves of M. sylvatica demonstrated potential for development of medicines.

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Section: Discussionunclassified

Composição química e toxicidade frente Aedes aegypti L. e Artemia salina Leach do óleo essencial das folhas de Myrcia sylvatica (G. Mey.) DC.

Rosa

Veras

Silva

et al. 2016

Rev. bras. plantas med.

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“…Oleanolic acid was extracted and isolated from the dried plant material as per procedures described earlier. 13) In brief, the ground plant material was first macerated with MeOH and the crude methanolic extract was concentrated and partitioned between hexane : MeOH/H 2 O (9 : 1), CHCl 3 : MeOH/H 2 O (6 : 4) and AcOEt : H 2 O (6 : 4). The chloroformic phase was then submitted to fractionation on silica gel column chromatography using the mixtures of CHCl 3 : MeOH/H 2 O in increasing polarity and the fractions obtained were purified by repeated chromatography and methylation processes so as to obtain pure methyl ester of oleanolic acid (2.5 g).…”

Section: Plant Materialsmentioning

confidence: 99%

Oleanolic Acid, a Pentacyclic Triterpene Attenuates the Mustard Oil-Induced Colonic Nociception in Mice

Maia

Lima-Júnior

David

et al. 2006

Biological & Pharmaceutical Bulletin

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Visceral pain is the most common form of pain for which the patients often seek medical care. Ascending pathways in the spinal cord that relay nociceptive information from the periphery to supraspinal central nervous system sites has been studied as potential targets for disrupting pain processing and providing relief. Despite the considerable advances in knowledge regarding the basic mechanisms underlying visceral pain and visceral hyperalgesia, no new effective therapies for abdominal pain have been discovered. Tissue injury, inflammation, and algesic chemicals produce changes in the stimulus response, leading to either sensitisation or desensitization of peripheral sensory afferents. An enormous range of pharmacological agents and endogenous substances via numerous receptors influence the visceral afferents. These substances produce their effects on visceral afferents by sensitization, opening of ion channels or by altering the expression of mediators, channels, or receptors. 1) In recent years, a central importance is given to capsaicin (vanilloid) receptor 1 (VR1, also called transient receptor potential V1, TRPV1) in the regulation of the activity of sensory afferent nerves. TRPV1 gene knock out mice are analgesic to a wide range of painful inflammatory states, suggesting that TRPV1 receptor antagonists may be effective in those pain states associated with tissue injury, and chemical exposure.2,3) Currently, inflammatory hyperalgesia is managed by NSAIDs (cyclo-oxygenase inhibitors) and opioids, although very effective against inflammatory hyperalgesia, both of these therapeutic classes possess significant limitations. 4,5) Opioids induce constipation, and nausea, whereas NSAIDs possess significant side effects on the gastrointestinal, cardiovascular and renal systems.In the recent past, many novel structures derived from a number of natural sources have been examined for the development of drugs acting as agonists or antagonists at vanilloid receptors, which include compounds like polygodial, a full vanilloid agonist derived from marsh pepper; warburganal from the bark of warburgia trees; isovelleral with terpenoid structure isolated from fungi; scalaradial, an unsaturated dialdehyde isolated from sponges; and scutigeral, isolated from edible mushrooms.6) The natural triterpenic mixture a-and b-amyrin, isolated from Protium heptaphyllum has recently been shown to exert gastroprotective effect against ethanolinduced lesions and an antinociceptive effect in the visceral model of nociception induced by capsaicin, possibly involving the capsaicin-sensitive sensory afferents. 7,8) Chemically, the a-and b-amyrin is a mixture of two triterpenes belonging to the ursane (a-amyrin) and oleanane (b-amyrin) series. Oleanolic acid is a pentacyclic triterpene that pertains to oleanane (b-amyrin) series (Fig. 1) and previous studies established its gastro-and hepato-protective and anti-inflammatory effects.9,10) So far there have been no available reports that show the efficacy of oleanolic acid in animal models of noci...

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“…To date, there are few chemical studies involving this species. Triterpenes and bioactive lignans have been isolated from its organic extracts [8,9]. …”

Section: Introductionmentioning

confidence: 99%

Bioactive Oleanane, Lupane and Ursane Triterpene Acid Derivatives

et al. 2012

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Betulinic, ursolic and oleanolic acids isolated from the aerial parts of Eriope blanchetii (Lamiaceae) were subjected to different esterification reactions, yielding 12 C-3 position ester derivatives. All compounds were identified using spectroscopic techniques, such as IR, 1H-NMR and MS. The derivatives were further investigated for their antioxidant level, Artemia salina lethality and antimicrobial activity.

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Lignanas e triterpenos do extrato citotóxico de Eriope blanchetii

Cited by 29 publications

References 4 publications

Composição química e toxicidade frente Aedes aegypti L. e Artemia salina Leach do óleo essencial das folhas de Myrcia sylvatica (G. Mey.) DC.

Composição química e toxicidade frente Aedes aegypti L. e Artemia salina Leach do óleo essencial das folhas de Myrcia sylvatica (G. Mey.) DC.

Oleanolic Acid, a Pentacyclic Triterpene Attenuates the Mustard Oil-Induced Colonic Nociception in Mice

Bioactive Oleanane, Lupane and Ursane Triterpene Acid Derivatives

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