Lignans from Mosla scabra Ameliorated Influenza A Virus-Induced Pneumonia via Inhibiting Macrophage Activation

Abstract

The lower respiratory tract infection, induced by influenza virus, coronaviruses, and respiratory syncytial virus, remains a serious threat to human health that can cause a global pandemic. Thus, finding effective chemicals and therapeutic measures to advance the functional restoration of the respiratory tract after infection has been the emphasis of the studies on the subjects. Mosla scabra is a natural medicinal plant used for treating various lung and gastrointestinal diseases, including viral infection, cough, chronic obstructive pulmonary disease, acute gastroenteritis, and diarrhoea. In this study, the antiviral and anti-inflammatory effects of total lignans (MSTL) extracted from the plant were investigated in influenza A virus (IAV)-infected mice and RAW 264.7 macrophages. MSTL could not only protect the macrophages against IAV-induced pyroptosis but also could lighten the lung inflammation induced by IAV in vivo and in vitro. The network pharmacology analysis revealed that differentially expressed genes, mainly involving in EGFR tyrosine kinase inhibitor resistance, endocrine resistance, HIF-1 signaling pathway, C-type lectin receptor signaling pathway, and FOXO signaling pathway, contributed to the IAV-induced alveolar macrophage dysfunction. It indicated that MSTL enhanced the function of alveolar macrophages and improved IAV-induced lung injury in mice.

UiO-66 nanoparticles combat influenza A virus in mice by activating the RIG-I-like receptor signaling pathway

“…MAPK and autophagy signaling pathways contributed to IAV virus-induced inflammation and lung injury [ 65 , 66 ]. FOXO signaling pathway has also been showed playing an important role in the IAV-induced alveolar macrophage dysfunction [ 67 ], and FoxO1 negatively regulated cellular antiviral response by promoting degradation of IRF3 [ 68 ]. The mTOR signaling pathway was most important for early IAV replication, and the use of mTOR inhibitor rapamycin could block IAV replication in vitro [ 69 , 70 ].…”

Association of dietary intake of polyphenols, lignans, and phytosterols with immune-stimulating microbiota and COVID-19 risk in a group of Polish men and women

“…There are currently no human studies available evaluating the effectiveness of higher dietary polyphenol, lignan and phytosterol intake in reducing COVID-19 risk. However, the antiviral efficacy of polyphenols including lignans and plant sterols has been confirmed against SARS-CoV, MERS-CoV, Ebola virus, HIV, influenza virus and other viruses causing respiratory tract infections (18)(19)(20)(21). Recent studies have also demonstrated their beneficial effects against the SARS-CoV-2 virus (18,(22)(23)(24) resulting from their ability to bind to peak protein sites on the ACE2 receptor used by SARS-CoV-2 to infect cells (25, 26), regulate ACE2 expression and also interfere with SARS-CoV-2 replication by inhibiting the virus protease or inhibiting SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) (27,28).…”

FoxO Transcription Factors: Applicability as a Novel Immune Cell Regulators and Therapeutic Targets in Oxidative Stress-Related Diseases

“…M . scabra flavonoids (MSF), in which the major active compounds were luteolin, apigenin, kaempferol, and moslosooflavone, decreased protein expressions of phosphating Akt/FoxO1 in both the lung tissues of IAV-infected mice as well as IAV-infected macrophages [ 122 ]. FoxO3a played an important role in glucocorticoids treatment of SLE by suppressing pro-inflammatory response.…”