Ligustrazine inhibits the proliferation and migration of ovarian cancer cells via regulating miR-211

Zhang, Hairong; Ding, Shichao; Lei, Xia

doi:10.1042/bsr20200199

Cited by 18 publications

(13 citation statements)

References 22 publications

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“…Upregulated miR-211 inhibits cell migration and invasion by downregulating SNAI1 in RCC [33]. Knockdown of miR-211 promotes the migration, invasion and EMT of OC cells [63].…”

Section: Migration and Invasionmentioning

confidence: 99%

“…PHF19 is a component of the polycomb group of proteins and negatively regulated by miR-211. Knockdown of miR-211 promotes the viability and proliferation of OC cells [63]. NSCLC: non-small cell lung cancer; HCC: hepatocellular carcinoma; RCC: renal cell carcinoma.…”

Section: Proliferation and Apoptosismentioning

confidence: 99%

“…Ligustrazine (LSZ) can significantly increase the expression of miR-211 in OC. Ligustrazine inhibits the OC cells proliferation and migration by regulating miR-211 [63]. Alpinetin suppresses OSCC cells proliferation by upregulating miR-211 and Notch Pathway deactivation [67].…”

Section: Other Factorsmentioning

confidence: 99%

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Role and mechanism of miR-211 in human cancer

Ye¹,

Wang²,

Wang³

et al. 2022

J. Cancer

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MircoRNA (miRNA), which are a group of small, and highly conserved non-coding RNA consisting of 18-25 nucleotides, can modulate gene expression at post-transcriptional level, through complementary binding to the 3ʹ-untranslated region (3ʹ-UTR) of numerous target genes. Emerging evidence indicates that miRNAs play critical roles in tumorigenesis and progression of cancer. Among them, miR-211 has been extensively studied in multiple cancers. The expression of miR-211 significantly varies with cancer types and may be used as a potential prognostic marker for cancer. MiR-211 can regulate multiple biological processes in cancer, including proliferation, apoptosis, metastasis and drug resistance. Additionally, several factors may contribute to the dysregulation of miR-211 in cancer. Consequently, this review aims to discuss the novel findings that highlight latent value of miR-211 in the prognosis assessment and treatment of cancer.

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“…Upregulated miR-211 inhibits cell migration and invasion by downregulating SNAI1 in RCC [33]. Knockdown of miR-211 promotes the migration, invasion and EMT of OC cells [63].…”

Section: Migration and Invasionmentioning

confidence: 99%

Section: Proliferation and Apoptosismentioning

confidence: 99%

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Role and mechanism of miR-211 in human cancer

Ye¹,

Wang²,

Wang³

et al. 2022

J. Cancer

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“…Tetramethylpyrazine (TMP) is a widely used medicinal compound extracted from Ligusticum Wallichil Franch. In SKOV-3 and OVCAR-3 cells, TMP significantly increased the expression level of miR-211, which could be partially abrogated by the knockdown of miR-211 [ 34 ]. TMP inhibited the cell viability, migration, and invasion ability of both cell lines in a dose-dependent pattern.…”

Section: Mechanisms With Natural Plants Compound In Ovarian Cancer Cellsmentioning

confidence: 99%

Mechanisms and Advances in Anti-Ovarian Cancer with Natural Plants Component

Zhou

Wang

et al. 2021

Molecules

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Ovarian cancer ranks seventh in the most common malignant tumors among female disease, which seriously threatens female reproductive health. It is characterized by hidden pathogenesis, missed diagnosis, high reoccurrence rate, and poor prognosis. In clinic, the first-line treatment prioritized debulking surgery with paclitaxel-based chemotherapy. The harsh truth is that female patients are prone to relapse due to the dissemination of tumor cells and drug resistance. In these circumstances, the development of new therapy strategies combined with traditional approaches is conductive to improving the quality of treatment. Among numerous drug resources, botanical compounds have unique advantages due to their potentials in multitarget functions, long application history, and wide availability. Previous studies have revealed the therapeutic effects of bioactive plant components in ovarian cancer. These natural ingredients act as part of the initial treatment or an auxiliary option for maintenance therapy, further reducing the tumor and metastatic burden. In this review, we summarized the functions and mechanisms of natural botanical components applied in human ovarian cancer. We focused on the molecular mechanisms of cell apoptosis, autophagy, RNA and DNA lesion, ROS damage, and the multiple-drug resistance. We aim to provide a theoretical reference for in-depth drug research so as to manage ovarian cancer better in clinic.

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“…The high mortality rate of ovarian cancer is attributed to the characteristics of its distant metastasis ( Li et al, 2005 ). TMP can reduce the viability, proliferation, migration, and invasion ability of the human ovarian carcinoma cell lines SK-OV-3 and OVCAR-3 by regulating miR-211, and the EMT is also involved in this process ( Zhang et al, 2021 ). TMP also inhibits the invasion and migration of SK-OV-3 cells by decreasing the expression of IL-8 through the ERK1/2, p38, and AP-1 signaling pathways, and IL-8 expression was significantly inhibited after coincubation with PD98059 (an ERK inhibitor) and SB203580 (a p38 inhibitor) ( Yin et al, 2011 ).…”

Section: Antitumor Mechanism Underlying the Effects Of Tetramethylpyrazine In Multiple Organsmentioning

confidence: 99%

Tetramethylpyrazine: A Review of Its Antitumor Potential and Mechanisms

Yang

Dai

et al. 2021

Front. Pharmacol.

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Cancer remains a major public health threat. The mitigation of the associated morbidity and mortality remains a major research focus. From a molecular biological perspective, cancer is defined as uncontrolled cell division and abnormal cell growth caused by various gene mutations. Therefore, there remains an urgent need to develop safe and effective antitumor drugs. The antitumor effect of plant extracts, which are characterized by relatively low toxicity and adverse effect, has attracted significant attention. For example, increasing attention has been paid to the antitumor effects of tetramethylpyrazine (TMP), the active component of the Chinese medicine Chuanqiong, which can affect tumor cell proliferation, apoptosis, invasion, metastasis, and angiogenesis, as well as reverse chemotherapeutic resistance in neoplasms, thereby triggering antitumor effects. Moreover, TMP can be used in combination with chemotherapeutic agents to enhance their effects and reduce the side effect associated with chemotherapy. Herein, we review the antitumor effects of TMP to provide a theoretical basis and foundation for the further exploration of its underlying antitumor mechanisms and promoting its clinical application.

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Ligustrazine inhibits the proliferation and migration of ovarian cancer cells via regulating miR-211

Cited by 18 publications

References 22 publications

Role and mechanism of miR-211 in human cancer

Role and mechanism of miR-211 in human cancer

Mechanisms and Advances in Anti-Ovarian Cancer with Natural Plants Component

Tetramethylpyrazine: A Review of Its Antitumor Potential and Mechanisms

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