LILRA3 Is Associated with Benign Prostatic Hyperplasia Risk in a Chinese Population

Jiao, Yang; Wang, Li; Gu, Xiaorong; Tao, Sha; Tian, Li; Na, Rong; Chen, Zhuo; Kang, Jian; Zheng, S. Lilly; Xu, Jianfeng; Sun, Jielin; Qi, Jun

doi:10.3390/ijms14058832

Cited by 10 publications

(12 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionmentioning

confidence: 94%

“…The detailed clinical characteristics of all subjects were described in detail in our previous study [9, 10]. Briefly, age distribution was significantly different between cases and controls ( P < 0.05).…”

Section: Resultsmentioning

confidence: 99%

“…Three SNPs, rs12621278 in ITGA6 at 2q31, rs339331 in RFX6 at 6q22, and rs103294 in LILRA3, were also significantly associated with BPH risk [10, 11]. More importantly, we found that rs12621278 and rs12653946 at 5p15 were significantly associated with BPH aggressiveness [10]. Although molecular mechanisms of these SNPs are unclear, this evidence supports the common influence mechanism of BPH/PCa and provides new insight into the genetics of BPH and clues about the direction of future studies.…”

Section: Discussionmentioning

confidence: 99%

“…Fifteen of these SNPs were associated with PCa risk in a Chinese population [7, 8]. The relationship between these SNPs and BPH was recently studied [9, 10]. Three SNPs: rs103294 at LILRA3, rs12621278 at 2q31, and rs339331 at 6q22, were significantly associated with BPH risk.…”

Section: Introductionmentioning

confidence: 99%

“…Three SNPs: rs103294 at LILRA3, rs12621278 at 2q31, and rs339331 at 6q22, were significantly associated with BPH risk. In addition, rs12621278 and rs12653946 at 5p15 were significantly associated with aggressive BPH [9, 10]. These results suggest that similar genetic mechanisms may predispose to benign and malignant prostate disease.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Association of a Common Variant at 10q26 and Benign Prostatic Hyperplasia Aggressiveness in Han Chinese Descent

Huang

Ding

et al. 2013

Biochemistry Research International

Self Cite

View full text Add to dashboard Cite

Recent studies reported that rs2252004 at 10q26 was significantly associated with prostate cancer (PCa) risk in a Japanese population and was subsequently confirmed in a Chinese population. We aimed to assess the relationship between this locus and risk/aggressiveness of benign prostatic hyperplasia (BPH). The current study included 426 BPH cases and 1,008 controls from Xinhua Hospital in Shanghai, China. All BPH patients were treated with α-adrenergic blockers and 5α-reductase inhibitors for at least 9 months. Associations between rs2252004 and BPH risk/aggressiveness were tested using logistic regression. Associations between rs2252004 and clinical parameters including International Prostate Symptom Score (IPSS), total prostate volume (TPV), total PSA (tPSA), and free PSA (fPSA) were evaluated by linear regression. Allele “A” in rs2252004 was significantly associated with increased risk for aggressiveness of BPH in a Chinese population (OR = 1.42, 95% CI: 1.04–1.96, P = 0.03). Patients with the genotype “A/A” (homozygous minor allele) had an increase of IPSS and TPV after treatment (P = 0.045 and 0.024, resp.). No association was observed between rs2252004, BPH risk, and baseline clinicopathological traits (All P > 0.05). Our study is the first to show that rs2252004 at 10q26 was associated with BPH aggressiveness and efficacy of BPH treatment.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Association of a Common Variant at 10q26 and Benign Prostatic Hyperplasia Aggressiveness in Han Chinese Descent

Huang

Ding

et al. 2013

Biochemistry Research International

Self Cite

View full text Add to dashboard Cite

show abstract

Benign prostatic hyperplasia

Chughtai

Forde

Thomas

et al. 2016

Nat Rev Dis Primers

323

224

View full text Add to dashboard Cite

donation during the early years of the AIDS epidemic. The demand for autologous transfusion has decreased as patients have become less concerned over the safety of transfusion, primarily because of improved testing for viral agents such as HIV and hepatitis. Other concepts that spare blood transfusion Erythropoietin, the red cell production hormone, can reduce the need for transfusion in stable medical patients with cancer and premature newborn infants. It can also be used to reduce the need for allogeneic transfusion in surgical patients, with or without concomitant autologous collection. 18 19 Perioperative anaemia and blood loss can also be dealt with by reducing the amount of blood lost at surgery through improving mechanical haemostasis, using antifibrinolytics such as aprotinin, limiting phlebotomy to essential diagnostic tests, and using microsample laboratory techniques. 20 Autologous transfusions also form part of a new concept of blood management called bloodless medicine and surgery. 21 This includes the use of erythropoietin, surgical techniques that minimise blood loss, and drugs that inhibit fibrinolysis; greater degrees of anaemia are tolerated, and phlebotomy undertaken for diagnostic testing is minimal. 20 Some of these methods are neither technically demanding nor expensive and may be adaptable to medical practice in less developed settings. The excellent results obtained in patients who are Jehovah's Witnesses, who refuse allogeneic transfusions, and the potential advantage of using fewer transfusions in patients in critical care support the promise of this concept for allogeneic transfusion. 22 Competing interests: NB has received lecture honorariums and consulting fees from Ortho Biotech.

show abstract

Heritability and genome-wide association study of benign prostatic hyperplasia (BPH) in the eMERGE network

Hellwege

Stallings²,

Torstenson

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Benign prostatic hyperplasia (BPH) results in a significant public health burden due to the morbidity caused by the disease and many of the available remedies. As much as 70% of men over 70 will develop BPH. Few studies have been conducted to discover the genetic determinants of BPH risk. Understanding the biological basis for this condition may provide necessary insight for development of novel pharmaceutical therapies or risk prediction. We have evaluated SNP-based heritability of BPH in two cohorts and conducted a genome-wide association study (GWAS) of BPH risk using 2,656 cases and 7,763 controls identified from the Electronic Medical Records and Genomics (eMERGE) network. SNP-based heritability estimates suggest that roughly 60% of the phenotypic variation in BPH is accounted for by genetic factors. We used logistic regression to model BPH risk as a function of principal components of ancestry, age, and imputed genotype data, with meta-analysis performed using METAL. The top result was on chromosome 22 in SYN3 at rs2710383 (p-value = 4.6 × 10 −7 ; Odds Ratio = 0.69, 95% confidence interval = 0.55–0.83). Other suggestive signals were near genes GLGC , UNCA13 , SORCS1 and between BTBD3 and SPTLC3 . We also evaluated genetically-predicted gene expression in prostate tissue. The most significant result was with increasing predicted expression of ETV4 (chr17; p-value = 0.0015). Overexpression of this gene has been associated with poor prognosis in prostate cancer. In conclusion, although there were no genome-wide significant variants identified for BPH susceptibility, we present evidence supporting the heritability of this phenotype, have identified suggestive signals, and evaluated the association between BPH and genetically-predicted gene expression in prostate.

show abstract

LILRA3 Is Associated with Benign Prostatic Hyperplasia Risk in a Chinese Population

Cited by 10 publications

References 18 publications

Association of a Common Variant at 10q26 and Benign Prostatic Hyperplasia Aggressiveness in Han Chinese Descent

Association of a Common Variant at 10q26 and Benign Prostatic Hyperplasia Aggressiveness in Han Chinese Descent

Benign prostatic hyperplasia

Heritability and genome-wide association study of benign prostatic hyperplasia (BPH) in the eMERGE network

Contact Info

Product

Resources

About