Aim: Several neurological disorders occur in women of the childbearing age group and are an important cause of maternal morbidity and mortality. The diagnosis and management of neurological disorders in pregnancy is always a challenging task due to varied symptomatology and risks to the fetus. A rare neurological disorder in pregnancy can be pregnancy related or can be caused by exacerbation of a pre-existing neurological condition or sometimes can be detected for the first time during pregnancy which might be an incidental finding. Treating these patients remain a challenge. Thus, our study aimed to determine the challenges in managing pregnant mothers with rare neurological complications in a tertiary health care hospital. Methods: All pregnant women with rare neurological conditions admitted to the