Limbal Autograft Transplantation for Ocular Surface Disorders

Kenyon, Kenneth R.; Tseng, Scheffer C.G.

doi:10.1016/s0161-6420(89)32833-8

Cited by 982 publications

(567 citation statements)

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“…Surgical details in both limbal grafting Eye and amniotic membrane transplantation procedures were similar to those described in previous reports. [11][12][13][14][15][16]18,19 After surgery, the recipient eye was treated with ofloxacin eyedrops one drop every 3 h, dexamethasone eyedrops one drop every 3 h, artificial eyedrops one drop every 2 h, and chloramphenicol ointment at bedtime. Topical steroids were tapered after 3 months and discontinued after 12 months, topical antibiotics were discontinued after 2 months.…”

Section: Methodsmentioning

confidence: 99%

“…Limbal autograft transplantation (LTau), a procedure for unilateral ocular surface disorders in which the limbal tissue is obtained from the unaffected eye, was first reported by Kenyon and Tseng in 1989. Limbal allograft transplantation (LTal) has been introduced for bilateral ocular surface disorders in which a heterologous limbal tissue is transferred either from a living, related donor eye or from cadaveric eye.…”

Section: Introductionmentioning

confidence: 99%

“…Promising results of these two surgeries have led the ophthalmologists to use these treatment methods in many types of ocular surface disorders in the recent years. [11][12][13] Both LTau and LTal are now proven to be successful for stabilizing ocular surface in patients with chemical and thermal burns. Comparisons of outcomes for ocular surface disorders due to various aetiologies and for the acute and chronic phases of corneal burns have been reported previously for limbal autografts and allografts separately.…”

Section: Introductionmentioning

confidence: 99%

“…Comparisons of outcomes for ocular surface disorders due to various aetiologies and for the acute and chronic phases of corneal burns have been reported previously for limbal autografts and allografts separately. 8,9,[11][12][13][14][15][16][17] In this study, besides investigating the surgical outcomes of LTau and LTal surgeries, we also aimed to compare the results of these two surgeries in patients with chemical and thermal burns.…”

Section: Introductionmentioning

confidence: 99%

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Limbal autograft and allograft transplantations in patients with corneal burns

Özdemir

Tekeli

Örnek

et al. 2004

Eye

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Aim To investigate and compare the surgical outcomes of limbal autograft and limbal allograft transplantations in patients with corneal burns. Methods In total, 20 patients (n ¼ 22 eyes) with chemical burn and two patients (n ¼ 2 eyes) with thermal burn were included in this study. Limbal autograft or limbal allograft transplantation surgery was performed in all patients. HLA-typing was tested before allograft surgeries. Limbal allografting was performed in all eyes using donor tissue from live relatives. Systemic cyclosporine A was administered for immunosuppression. Results The corneal surface was successfully reconstructed in all eyes (100%) after limbal autografting, two eyes required additional amniotic membrane transplantation and one eye required allografting. The mean follow-up period for limbal autografts was 13.977.0 months. Limbal allografting failed to reduce corneal vascularity and opacification in five (55.6%) eyes and was successful only in four (44.4%) eyes (mean follow-up 16.2711.2 months) (P ¼ 0.002). In all, 15 eyes undergoing limbal autografting completed reepithelialization of the cornea at a mean of 35.6760.2 days. The mean epithelial healing time in nine eyes undergoing limbal allografting was 13.077.3 days (P ¼ 0.525). After limbal autografting, functional vision (Z1/10) was attained in 12 (80%) eyes. Only one eye (11.1%) achieved functional vision after limbal allografting (P ¼ 0.036). Penetrating keratoplasty was performed in three patients following limbal allografting. No cyclosporine-associated side effects were observed. Conclusions Limbal autograft transplantation is an effective and safe procedure for unilateral corneal burns.It seems that limbal allograft transplantation is better combined with penetrating keratoplasty for a better visual outcome and higher graft survival rate. Systemic immunosuppression seems to be necessary for limbal allografts even in the presence of HLA-matched donor tissues.

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