Limbic and Corpus Callosum Aberrations in Adolescents with Bipolar Disorder: A Tract-Based Spatial Statistics Analysis

Combined analysis of grey matter voxel-based morphometry and white matter tract-based spatial statistics in late-life bipolar disorder

“…Overall, the few previous DTI studies reported reduced fractional anisotropy and increased radial diffusion in the frontal and prefrontal lobes, internal capsule, corpus callosum and uncinate fasciculus of patients with bipolar disorder. [18][19][20][21][22][23][24] Tract-based spatial statistics (TBSS) is a recently introduced advanced analysis technique that projects all individual DTI parameters onto a group average white matter skeleton, reducing potential spatial misregistrations. 25 Only 2 TBSS studies were performed in young patients with bipolar disorder, showing a reduction in fractional anisotropy, notably in the corpus callosum and fornix 22 as well as in the right uncinate fasciculus.…”

“…[18][19][20][21][22][23][24] Tract-based spatial statistics (TBSS) is a recently introduced advanced analysis technique that projects all individual DTI parameters onto a group average white matter skeleton, reducing potential spatial misregistrations. 25 Only 2 TBSS studies were performed in young patients with bipolar disorder, showing a reduction in fractional anisotropy, notably in the corpus callosum and fornix 22 as well as in the right uncinate fasciculus. 26 Despite the interest in exploring the persistence of neurodevelopmental deficits and possible neurodegenerative changes, MRI studies in middle-aged and elderly patients with bipolar disorder are very rare.…”

Neuroimaging Data in Bipolar Disorder: An Updated View

“…Similar findings have been reported even in children and adolescents with BD, concluding that in these subjects significant white matter tract alterations were present in regions involved in emotional, behavioural and cognitive regulation. In addition, these results suggest that alterations in white matter are present early in the course of disease in familial BD (Barnea-Goraly et al, 2009;Kavafaris et al, 2009). An impaired fiber density in anterior corona radiata (as detected with a decreased fractional anisotropy) was detected in BD in pediatric age and in Attention Deficit and Hyperactivity Disorder suggesting a possible link between the two disorders (Pavuluri et al, 2008).…”

Emotional and Motivational Processes in Bipolar Disorder: A Neural Network Perspective

“…During depression, mania, and euthymia, reduced white matter integrity, especially in the anterior corpus callosum in children and adolescents [167][168][169][170] as well as in adults [171][172][173][174][175][176][177] suffering from bipolar disorder, has been described. Interestingly, a normalizing effect of lithium on the volume of the corpus callosum has been observed [178], and a study of euthymic bipolar disorder patients even reported increased integrity of the corpus callosum [179].…”

“…There are some studies stating that psychotropic medication such as lithium, antidepressants, or antipsychotics do not affect the corpus callosum [167,173,176,177,179,[192][193][194][195], although thickening of the corpus callosum has also been observed after lithium treatment [196]. Similarly, the white matter integrity of the anterior limb of the internal capsule and the uncinate fasciculus were not influenced by psychotropic medication [173,180,183].…”