Limitations of Conventional Parameters and Role of Urinary Protein Biomarkers in the Determination of Drug Induced Acute Kidney Injury in Very Early Stage

Sundaram, Rajeshwari; Abhirama, B R; Gowtham, L.; Kalpana, Gladys; Sudha, M.; Thiyagarajan, Thirumagal; Shankarappa, Pushpa; Priyadharsini, G.

doi:10.9734/bjpr/2014/13446

Cited by 3 publications

(2 citation statements)

References 58 publications

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“…Over the last decade, efforts have been made to identify and characterize new BM for early diagnosis. [2][3][4] The FDA and the EMA have simultaneously encouraged research programs for the identification and qualification of early BM of drug-induced kidney injury (DIKI). 5 These new renal BM can be classified as functional BM or tissue injury BM (Figure 1).…”

Section: F I G U R E 1 Classification Of New Biomarkers By Nephron Segmentmentioning

confidence: 99%

Investigation of new biomarkers of kidney injury in renal transplant recipients undergoing graft biopsy

Michon

Dürrbach

Gautier

et al. 2021

Clinical Transplantation

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Aim: Urinary and blood kidney biomarkers (BM) remain insufficient for early kidney injury detection. We aimed to compare new kidney BM with histopathological data in kidney allograft recipients. Methods: Blood and urine samples were collected from consecutive adult patients just before graft biopsy. All kidney samples were classified according to the Banff 2007 classification. The diagnostic performance of 16 new BM was compared to those of urinary proteins, blood urea nitrogen, eGFR, and serum creatinine to identify histopathological groups. Results: Two hundred and twenty-three patients were analyzed. Microalbuminuria and urinary proteins performed well to discriminate glomerular injury from slightly modified renal parenchyma (SMRP). Urinary neutrophil gelatinase-associated lipocalin (NGAL) had the best performance relative to SMRP (AUROC .93) for acute tubular necrosis (ATN) diagnosis. Other BM had a slightly lower AUROC (.89). For the comparison of ATN to acute rejection, several new urinary BM (NGAL, cystatin C, MCP1) and classical BM (eGFR, serum creatinine) gave similar AUROC values (from .80 to .85).Urinary NGAL values in patients with ATN were 10-time higher than those with acute rejection (P=.0004). Conclusion:The new BM did not outperform classical BM in the context of renal transplantation. Urinary NGAL may be useful for distinguishing between ATN and acute rejection.

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Section: F I G U R E 1 Classification Of New Biomarkers By Nephron Segmentmentioning

confidence: 99%

Investigation of new biomarkers of kidney injury in renal transplant recipients undergoing graft biopsy

Michon

Dürrbach

Gautier

et al. 2021

Clinical Transplantation

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“…Upon dissociation, the MRC recycles back to the luminal membrane, becoming available for a new endocytosis process. The LMWPs follow the lysosomal pathway, where they are degraded into amino acids or, in smaller amounts, proceed through the transcytosis pathway [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Urinary Transferrin as a Marker of Renal Injury in Diabetic Individuals: An Integrative Review

Gusmão,

Costa,

Gonsalez

et al. 2024

J. Adv. Med. Med. Res.

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Aims: Chronic Kidney Disease (CKD) significantly impacts public health, with diabetes mellitus as the second leading cause, according to the latest Brazilian Dialysis Census. CKD is linked to obesity, hypertension, and family history. While microalbuminuria is a common marker for diabetic nephropathy (DN), its limitations prompt the need for alternative biomarkers. Over the past two decades, urinary transferrin has been explored for its enhanced glomerular filtration. This review evaluates transferrin's clinical-laboratory utility as a kidney injury biomarker. Methodology: The research was an integrative review, guided by the PRISMA checklist and the PICO model. It examined the role of urinary transferrin as a kidney injury marker in diabetics. Data were sourced from PubMed, Scopus, Cinahl, Web of Science, and Cochrane Database using MeSH terms. The Rayyan platform helped filter studies, with CASP ensuring quality. Inclusion criteria covered randomized trials from 2002-2021, focusing on urinary samples. The CONSORT guidelines assessed study reliability, ensuring robust conclusions. Results: The findings suggest that urinary transferrin may have superior sensitivity in detecting glomerular damage in diabetic patients compared to microalbuminuria. It serves as an early indicator of diabetic nephropathy (DN) and can predict the onset of microalbuminuria and the progression of chronic kidney disease (CKD). Conclusion: This study emphasizes the need to clarify the role of urinary transferrin as an experimental laboratory marker for kidney injury in diabetic patients. It highlights the importance of moving from discovery to validation of new urinary biomarkers and developing diagnostic methods that include urinary transferrin for early diabetic nephropathy (DN) diagnosis.

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Effects of Genetic Polymorphism on Susceptibility to Nephrotoxic Properties of BTEXs Compounds

Neghab

Nourozi

Shahtaheri

et al. 2018

Journal of Occupational &Amp; Environmental Medicine

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Limitations of Conventional Parameters and Role of Urinary Protein Biomarkers in the Determination of Drug Induced Acute Kidney Injury in Very Early Stage

Cited by 3 publications

References 58 publications

Investigation of new biomarkers of kidney injury in renal transplant recipients undergoing graft biopsy

Investigation of new biomarkers of kidney injury in renal transplant recipients undergoing graft biopsy

Urinary Transferrin as a Marker of Renal Injury in Diabetic Individuals: An Integrative Review

Effects of Genetic Polymorphism on Susceptibility to Nephrotoxic Properties of BTEXs Compounds

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