Limitations of the ACTH Regulating Effect of Corticoids

Fortier, Claude; Yrarrazaval, S.; Selye, Hans

doi:10.1152/ajplegacy.1951.165.2.466

Cited by 15 publications

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“…This observation has been confirmed by many investigators (2-7), but not by all (8). In man the clinical, morphological and biochemical evidence for steroidal inhibition of pituitary secretion is impressive but there are few actual measurements of blood ACTH reported.…”

mentioning

confidence: 71%

Plasma Adrenocorticotrophic Hormone in Addison's Disease and its Modification by the Administration of Adrenal Steroids

Bethune¹,

Nelson²,

Thorn³

1957

J. Clin. Invest.

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mentioning

confidence: 71%

Plasma Adrenocorticotrophic Hormone in Addison's Disease and its Modification by the Administration of Adrenal Steroids

Bethune¹,

Nelson²,

Thorn³

1957

J. Clin. Invest.

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“…The findings of Sayers & Sayers (1947) have been only partially confirmed. Some workers have found that the stress-induced secretion of ACTH can be prevented only by massive doses of corticoids (Hodges, 1953(Hodges, , 1954Abelson & Baron, 1952) and others have failed to show any ability of these steroids to suppress ACTH release (Moya & Selye, 1948;Hall, Finerty, Hall & Hess, 1951;Fortier, Yrarrazaval & Selye, 1951). A further demonstration that the secretion of ACTH -is not necessarily controlled by changes in the level of corticoids in the blood was provided by Sydnor & Sayers (1954) when they found that adrenalectomized animals are still capable of secreting adrenocorticotrophic hormone in response to stress.…”

Section: (Received 5 October 1959)mentioning

confidence: 99%

The effects of hydrocortisone on the level of corticotrophin in the blood and pituitary glands of adrenalectomized and of stressed adrenalectomized rats

Hodges¹,

Vernikos²

1960

The Journal of Physiology

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“…The reduction in size of the " X " zone in these experiments could be due to stimulation of the zona fasciculata to produce corticosteroids (or their intermediates), some of which have androgenic activity (Moon, 1961). Such adrenal gland stimulation could be effected by the small amounts of histamine absorbed from the nasal mucosa, mouth, or digestive tract and act in a similar manner to the " stress" reaction (Fortier, Yrarrazaval and Selye, 1951;Ohno, 1962). Involution of the " X " zone appeared less acute than that observed in stressed, starved or formalin-injected mice (Ohno, 1962) but some lipid accumulation, cedema and increased vascularity were noted.…”

Section: Discussionmentioning

confidence: 99%

Efect of Histamine on Reproduction in Female Mice

Bigland

Shifrine

1965

British Journal of Pharmacology and Chemotherapy

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Histamine fed to laying chickens causes an abrupt cessation of egg production (Shifrine, Adler & Burkhalter, 1963). Experiments were thus designed to determine whether ingested histamine has an effect on the reproductive system of mice.In this paper we describe the effect of histamine fed to mice on ovulation and the oestrous cycle, pregnancy, the size of the adrenal "X " zone and medulla, food and water consumption, and the output of urine and faeces. METHODSFive experiments were conducted on 126 virgin and 10 pregnant Swiss White Mice (Webster Strain C3) using groups of five to fifteen in each experiment. The mice were housed in metal cages or plastic metabolic cages. They were maintained in the experimental environment for at least 3 days and given pulverized mouse feed. The experimental diets were pulverized commercial mouse rations mixed with histamine diphosphate to give 0.1 or 0.25% histamine as free base. A record was kept of the daily food and water consumed, and the output of urine and faeces. The mice were weighed daily and at necropsy.In pregnancy studies the pregnant mice were allowed to litter and were then immediately bred and held in metabolic cages to observe date of parturition and thus to assess date of conception. Vaginal smears were taken daily for 10 days from virgin females 60 days old and fed 0.1 and 0.25% histamine, and from control mice. The smears were stained with Giemsa and cells were examined to assess the stage of the oestrous cycle and the occurrence of ovulation (Snell, 1941). The latter was also determined by the character of maturing ovarian follicles, corpora haemorrhagica, and corpora lutea on gross and microscopic examination after mice were fed 0.1 or 0.25% histamine for periods ranging from 7 to 31 days.In all instances only the right adrenal gland was removed for sectioning. For histopathological studies, tissues were fixed in 10% neutral formalin and stained with haematoxylin and eosin. After staining, the adrenal " X " zone and medulla were measured with a microscopic ocular reticle at x 110. In each case only adrenal sections which were cut clearly across the centre of the gland, and only in areas representative of the whole gland, were chosen for measurements. This greatly reduced the number of adrenal glands used for tabulation.Ratios reported are of " X " zone relative to the total adrenal cortex, and medulla as a percentage of the total width of gland. RESULTSMice kept in plastic metabolic cages and fed 0.1 or 0.25% histamine were initially observed to behave in a more agitated manner than the controls. This included constant movement about the cage, increased nose scratching and more wastage of food and water.

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Limitations of the ACTH Regulating Effect of Corticoids

Cited by 15 publications

References 0 publications

Plasma Adrenocorticotrophic Hormone in Addison's Disease and its Modification by the Administration of Adrenal Steroids

Plasma Adrenocorticotrophic Hormone in Addison's Disease and its Modification by the Administration of Adrenal Steroids

The effects of hydrocortisone on the level of corticotrophin in the blood and pituitary glands of adrenalectomized and of stressed adrenalectomized rats

Efect of Histamine on Reproduction in Female Mice

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