Limited evidence for a beneficial effect of vitamin C supplementation on biomarkers of cardiovascular diseases: an umbrella review of systematic reviews and meta-analyses

Ashor, Ammar W.; Brown, Rebecca; Keenan, P.; Willis, Naomi D.; Siervo, Mario; Mathers, John C.

doi:10.1016/j.nutres.2018.08.005

Cited by 59 publications

(51 citation statements)

References 47 publications

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“…Current prevention guidelines recommendations are a percentage of trans-unsaturated fatty acids <1% of energy intake, consumption of < 5 g salt/day, limitation of alcoholic drinks and discouragement of sweetened/carbonated drinks (7). Even if there are studies (pro and con) on the impact that certain nutrients and vitamins may have on cardiovascular pathology (selenium -(37-40), thiamine - (41,42), vitamin C - (43,44), magnesium -(4-47), zinc (48), monitoring of intake within rehabilitation programs is rarely performed. The study of food menus and their adaptation to patients' particularities would involve nutritional analysis from the perspective of the recipe and preparation technology, providing information related to the nutritional and energy value of the menus, salt content, fat, saturated fat, sugar and particularly nutrients, vitamins (much more rarely evaluated, as mentioned before).…”

Section: Preliminary Results Stage I -Based On the Data Provided By Umentioning

confidence: 99%

Collaborative platform development in nutrition as support for cardiovascular patients’ rehabilitation

Sitar‐Tăut

Sitar-Tăut

Mican

et al. 2019

BALNEO

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Introduction. Enrollment of patients with cardiovascular disease in rehabilitation programs may contribute to implementation of a healthy lifestyle, including by promotion of a diet adequate for each patient’s profile. In this context, the current study is aimed at creating a traffic light system model allowing to obtain the development, innovation and diversification of menus and to improve the nutritional programs for this category of patients. Material and method. Based on the data provided by USDA Food Composition Databases, the composition in terms of different nutritive principles was determined for each ingredient and for each final menu. Comparison of menus depending on each nutritive principle, as well as comparison between menus and nutrient requirements according to indications for patients attending cardiovascular rehabilitation programs was made. Results. The traffic light system was developed, using color codes, comparing daily nutrient requirements with preparations’ content. Conclusions. The major benefit of the traffic light system would reside in the fact that starting from classic menus, an intervention on these can be achieved, and healthier, more nutritionally balanced models can be created, according to healthy nutrition principles. These new menus will be calorically and nutritionally adapted for patients attending cardiovascular rehabilitation programs. Key words: nutrition, rehabilitation, traffic light system,

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Section: Preliminary Results Stage I -Based On the Data Provided By Umentioning

confidence: 99%

Collaborative platform development in nutrition as support for cardiovascular patients’ rehabilitation

Sitar‐Tăut

Sitar-Tăut

Mican

et al. 2019

BALNEO

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“…Vitamin C could also prevent postoperative atrial fibrillation in cardiac surgery (Hemilä and Chalker 2019;Hemilä and Suonsyrjä 2017;Putzu et al 2019;Shi et al 2018). On the other hand, the results of clinical trials are not conclusive, and sometimes controversial, in the current state of knowledge, concerning the relationship between vitamin C intake and cardiovascular diseases (Al-Khudairy et al 2017;Ashor et al 2014Ashor et al , 2019 and between vitamin C intake and cognitive function (Crichton et al 2013;Li et al 2012;Travica et al 2017).…”

Section: ; Padayatty and Levine 2016)mentioning

confidence: 98%

Plant Kingdom as Source of Vitamins

Hennebelle¹

2020

Handbook of Dietary Phytochemicals

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A vitamin is an organic substance necessary, in small quantities, for the correct functioning of the metabolism of a living organism. It is an essential nutrient because this substance cannot be synthesized in sufficient quantity by this organism and thus must be provided through the food intake. Each organism has specific needs: a molecule can be a vitamin for one species and not be it for another. It is the case for example of Vitamin C. Some vitamins are water-soluble compounds, including all vitamin Bs (B1, B2, B3, B5, B6, B7, B9, B12) and vitamin C. Others are fat-soluble compounds and encompass vitamins A, D, E, and K. In this chapter, we have chosen to provide an overview of recent literature data only about vitamins provided exclusively or significantly by plant food, in particular vitamins A (as provitaminic carotenoids), B1, B9, C, E, and K1. Vitamins provided by animal food, such as vitamin D or vitamin B12, will be not discussed in this chapter.

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“…Recent umbrella review brings only limited evidence for the effect of vitamin C supplementation on biomarkers of cardiovascular diseases or its risk factors, such as arterial stiffness, blood pressure, endothelial function, glycemic control, and lipid profile. There is only weak evidence that supplemental vitamin C may improve these biomarkers in selected population subgroups (older and/or obese people, patients with lower vitamin C status at baseline, and patients with a higher risk of cardiovascular disease) [190]. Some recent systematic reviews and meta-analyses suggested that vitamin C significantly decreased the incidence of atrial fibrillation, ventilation time, length-of-stay in the intensive care unit, and hospital length-of-stay, but it had no significant effect on in-hospital mortality or incidence of stroke, acute kidney injury, or ventricular arrhythmia in cardiac surgery patients.…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

Vitamin C—Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination

et al. 2021

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Vitamin C (L-ascorbic acid) has been known as an antioxidant for most people. However, its physiological role is much larger and encompasses very different processes ranging from facilitation of iron absorption through involvement in hormones and carnitine synthesis for important roles in epigenetic processes. Contrarily, high doses act as a pro-oxidant than an anti-oxidant. This may also be the reason why plasma levels are meticulously regulated on the level of absorption and excretion in the kidney. Interestingly, most cells contain vitamin C in millimolar concentrations, which is much higher than its plasma concentrations, and compared to other vitamins. The role of vitamin C is well demonstrated by miscellaneous symptoms of its absence—scurvy. The only clinically well-documented indication for vitamin C is scurvy. The effects of vitamin C administration on cancer, cardiovascular diseases, and infections are rather minor or even debatable in the general population. Vitamin C is relatively safe, but caution should be given to the administration of high doses, which can cause overt side effects in some susceptible patients (e.g., oxalate renal stones). Lastly, analytical methods for its determination with advantages and pitfalls are also discussed in this review.

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Limited evidence for a beneficial effect of vitamin C supplementation on biomarkers of cardiovascular diseases: an umbrella review of systematic reviews and meta-analyses

Cited by 59 publications

References 47 publications

Collaborative platform development in nutrition as support for cardiovascular patients’ rehabilitation

Collaborative platform development in nutrition as support for cardiovascular patients’ rehabilitation

Plant Kingdom as Source of Vitamins

Vitamin C—Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination

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